Cov lus qhia
| Zog: | Tawm dawb rau lub teeb daj amorphous hmoov |
| Solubility Clarity: | 0.2m kev daws teeb meem hauv cov acetonitrile yog pub dawb los ntawm tsis muaj qhov cuam tshuam |
| Tus kheej (los ntawm 1H NMR): | Txhawm rau ua raws cov qauv |
| Purity (HPLC): | 98% min |
| Purity (31p NMR): | 98% min |
| Residual Hnyav: | 3% max |
| Cov ntsiab lus noo: | 0.5% max |
Cov Ntawv Thov
1. Khoom cua ntawm hloov kho oligonucleides
Ua rau cov kev sib txuam ntawm 2'-o-moe adenosine rau hauv RNA lossis antisense oligonucleides (asos).
Siv rau hauv cov khoom siv-theem hluavtaws los tsim cov tshuaj ruaj khov oligos nrog txhim kho kev kho lub peev xwm.
2. Antsisense Kho
2'-o-me kev hloov kho txhim kho kev tiv taus nucleests, nce hauv vivo ruaj khov.
Txhim khu kev sib tsoo ib qho muaj kev sib haum xeeb kom tau nyiaj ntau, txhim kho potency.
Txo cov kev cuam tshuam tawm ntawm hom phiaj thiab kev lom zem los ntawm kev nce ntxiv.
3. Kev tshawb fawb nyob rau hauv cov thawj tswj kev cai
Pab tau rau kev tsim hloov hloov oligos mus kawm cov gene knockdown thiab phev tawm.
Pab txhawb nqa cov tshuab kev cuam tshuam RNA thiab kev tiv thaiv kom tsis sib haum-cov noob qab sib dhos.
4. Kev kuaj mob thiab cov cuab yeej molecular
Incorporated rau hauv kev ua haujlwm rau hybridier cia, pr presters, thiab molecular kuaj yuav tsum tau muaj cov muaj feem tshwj xeeb thiab kev ruaj ntseg.
Cov txiaj ntsig
✔ Ntau zuj zus
Qhov 2 '-o-moe hloov kho kom tiv thaiv enzymatic degradation, prolonging oligonucleide ib nrab-lub neej.
✔ Ua kom zoo dua los ntawm kev muaj affinity
Moe pab pawg nce thermal ruaj khov (tm) ntawm duplexes, uas ua rau muaj zog thiab ntau dua cov hybridization.
Og Kev rho tawm impunogenicity
2'-o-moe hloov oligonucleights nyiam kev tiv thaiv kev tiv thaiv kab mob tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg tsawg.
✔ txoj kev txuag hluavtaws siab
N6-BenzoyL thiab phosphoramidemation tiv thaiv pawg kom zoo, high-resple Coupling thaum synthesis.
✔ Versatility
Tau tshaj nrog ntau hom Oligonucleotide chicontries thiab ua ntu zus, muab cov kev tshawb nrhiav thiab cov ntaub ntawv kho.
Tag
2'-o-moe-n6-benzoyl-adenosine phosphoramidite (CAS 25 Nws txhim kho Nuclease tsis kam, los ntawm kev ua yeeb yam zoo, thiab txo kev txhaj tshuaj tiv thaiv kab mob, ua rau muaj kev ruaj khov thiab siv tau cov tshuaj. Nws cov ntawv thov Spans Molecular Kev Tshawb Fawb Biology, kev kuaj mob, thiab kws tshuaj Oligonucleide synthesis, ua nws cov cuab yeej tseem ceeb hauv kev nce qib RNA-based technologies.
Cim npe nrov: 2'-o-moe-n6-benzoyl-adenosine phosphoramidite 丨 cas 251647-53-丨-moe-adenosine phosphoramidation 丨 CASTORS, US3-74-7-53-7
