Cov lus qhia
| Zog: | Dawb rau off-dawb hmoov |
| Solubility Clarity: | 0.2 m kev daws teeb meem hauv acetonitrile yog pub dawb los ntawm tsis muaj kev cuam tshuam |
| Tus kheej (los ntawm HNMR): | Txhawm rau ua raws cov qauv |
| Purity (HPLC): | 99.0% min |
| Ib qho tseem ceeb impuration: | 0.3% max |
| Tsis yog-tseem ceeb ib qho impurity: | 0.5% max |
| Tsis paub ib leeg impurity: | 0.3% max |
| 31P NMR Purity: | 98.0% min |
| P (iii) impurities (100-170 ppm): | 0.5% max |
| Residual Hnyav: | 3.0% Max |
| Nws noo: | 0.5% max |
Cov Ntawv Thov
1. Khoom cua ntawm hloov kho oligonucleides
Cov Reagent reagent rau sib xyaw ua ke 2'-F-DC rau hauv DNA lossis RNigonucleides.
Siv nyob rau hauv Antisens OligonucleAs (Asos), sirna, aptamers, thiab lwm yam kho lossis kev tshawb nrhiav kev tshawb fawb.
2. RNA HHNAPEUTICS KEV LOJ
2'-f-dc txhim kho kom enzymatic degradation, txuas ntxiv RNA ib nrab-lub neej hauv vivo, thiab txhawb nqa lub hom phiaj kev koom tes.
Feem ntau siv nyob rau hauv ib nrab lossis tag nrho 2'-hloov kho Oligonucucleide Backbones rau cov khoom muaj roj ntsha zoo.
3. RNA Mimicry Hauv Kev Tshawb Fawb
Txhawb nqa cov qauv txheej txheem thiab cov kev tshawb fawb biochemical uas cuam tshuam nrog cov noob pob zeb uas zoo li molecules.
Pab soj ntsuam RNA-protein kev sib cuam tshuam, RNA folding, thiab hybridization muaj zog.
4. Kev kuaj mob thiab probes
Qhov zoo tagnrho rau kev tsim nucleic acid primes siv hauv QPRC, hybridier cia, thiab molecular kev kuaj mob uas xav tau siab thermal stability thiab tshwj xeeb.
Cov txiaj ntsig
✔ High NucLease Kuj
Cov tshuaj 2 lub fluoro hloov tau nce siab txog Ribonucupleasases, tseem ceeb rau hauv Vivo daim ntawv thov.
✔ Tau txais Duplex kev ruaj khov
Ua kom muaj qhov kub yaj kub me yaj (TM) thiab txhim kho lub hom phiaj khi khi rau hauv kev sib haum xeeb hauv hybrid duplexes.
Og Kev rho tawm impunogenicity
2 '-f hloov kho cov kev ua kom muaj zog tiv thaiv kev tiv thaiv kev tiv thaiv, ua rau lawv muaj kev nyab xeeb dua rau kev txhim kho.
✔ Kev sib raug zoo tau zoo
Cov pab tiv thaiv tiv thaiv kom huv si, high-respatibling thiab compatibility coupling thiab compatibility nrog cov phosphoramitite kev ntsuas.
✔ Ntau heev siv
Pab tau nyob rau hauv ob qho tib si DNA-li thiab RNA-zoo li oligonucleotide tsim, muab cov khoom siv hloov rau cov boot-tune boot pob qaum qaum teb.
Tag
5-O-DMT-2′-Fluoro-dC(N-Ac)-3′-CEDPA (CAS 159414-99-0) is a high-performance phosphoramidite for introducing 2′-fluoro-modified cytidine into synthetic oligonucleotides. Nws txhim kho kev ruaj khov stability, hybridization lub zog, thiab txo nws immunogenicity, ua nws ib qho kev kho mob uas tseem ceeb, thiab tshuaj tiv thaiv thev naus laus zis. Dav siv nyob rau hauv nucleic acid tshuaj nrhiav pom thiab kev ua haujlwm RNA kev tshawb fawb, nws txhawb nqa kev tsim cov khoom lag luam tom ntej, thiab zoo oligonucleotides.
Cim npe nrov: 5-O-DMT-2-F-DC (N-AC) -3-CEDPA 丨 CAS 159414-99-0, Suav 5-F-DC (N-ACCT-2-T-DC (N-ACCE)
