2, {{{3- dideoxyguanosine 丨 CAS 85326-06-3

2? Qhov kev hloov pauv no tiv thaiv kev tsim ntawm ib qho 3 '-5' Phosphoditer Bond, ib qho tseem ceeb uas ua rau tus caj qaum ntawm DNA thiab RNA.

1. Kev tshawb fawb tawm tsam thiab kev tsim tshuaj
a. HIV thiab Rhipirus Kho (NRTI Prototyping):
2, {3- dideoxyguanosine 丨 CAS {2}} belongs rau chav kawm ntawm nucleoside rov qab transcriptase inibitors (NRTIS). Los ntawm cov nimicking ntuj nucleosides, nws tuaj yeem cuam tshuam rau hauv cov kab mob kis thaum thaum rov ua dua. Txawm li cas los xij, vim qhov tsis muaj 3 'pab pawg hydroxyl, cov saw hlau tsis tuaj yeem txuas ntxiv, ua rau kev txiav tawm thaum ntxov ntawm kab mob DNA synthesis.
● Cov txheej txheem no yog qhov tseem ceeb rau ntau cov tshuaj antiretreiral, thiab thaum 2 {
b. Kev Siv Hluav Taws Xob Hluav Taws Xob Dav Hlau:
Nws tau kawm txog cov kev ua uas muaj peev xwm tiv thaiv lwm tus RNA thiab DNA cov kab mob, xws li tus kab mob siab (HBV) thiab cov tshuaj ntsuab B, vim nws txoj saw-lo lus kaw.

2. Kev tshawb fawb txog kev tshawb fawb txog kev kawm biology
a. DNA \/ RNA Polymerase Tripies:
Vim tias nws lub peev xwm los tshem tawm nucleic kua qaub elongation, 2, 3- dideoxyguanosine yog siv nyob rau hauv vitro polymerase siv rau:
● Kev sojntsuam xim polymerase
● Tshuaj xyuas cov saw txiav
● Daim ntawv qhia cov chaw ua haujlwm ntawm cov transcriptases rov qab
b. Kev sib txuas thiab nucleotide analogs:
Zoo li lwm cov dej qabneoxerucleosides (piv txwv li, ddtp), nws tuaj yeem siv rau hauv cov txheej txheem neeg vwm, yog hais tias guanine analogs tsis tshua muaj ntau dua li lwm tus hauv lub luag haujlwm no.

3. Cov Tshuaj Kho Mob Chemistry thiab analog synthesis
a. Prodrrug thiab derivative kev loj hlob:
2, {3- dideoxyguanosine ua raws li cov qauv tseem ceeb rau kev sib xyaw ntawm cov tshuaj tiv thaiv kev ua haujlwm, suav nrog:
● Prodrugs nrog cov txiaj ntsig zoo dua
● Lipophilic analogs rau kev txhim kho cellular uptake
● conjugates nrog phiaj ligands rau cov khoom lag luam xaiv
b. Tus qauv-kev sib raug zoo (SAR) kev tshawb fawb:
Nws yog dav siv hauv cov tshuaj chemical los tshawb nrhiav cov kev hloov kho no rau cov nucleosit cuam tshuam rau cov kev ua ub no, cytotoxicity, thiab cov khoom lag luam tawm tsam.

4. Oncology thiab Antimetabolite kev tshawb fawb
Raws li nucleoside analog, 2, {3- dideoxyguanosine yuav cuam tshuam nrog DNA synthesis nyob rau hauv sai sai, ua rau nws txaus siab rau:
● Kev tshawb fawb txog biology biology-tshwj xeeb rau kev kawm cov txheej txheem ntawm kev rov ua dua.
Cov kev txhim kho ntawm kev txhim kho-tej yam kev suav nrog hauv cov tsev qiv ntawv piav qhia txog kev ntsuas lossis cytotoxic.

1. Potent Saw Terminator nyob rau hauv nucleic acid synthesis
Los ntawm tsis muaj ob qho tib si 2 'thiab 3' molroxyl pawg, no molecule muaj txiaj ntsig zoo, ua rau nws muaj txiaj ntsig hauv kev tshawb fawb acid thiab nucleic acid tshawb.
2. Cov cuab yeej rau kev nkag siab txog kab mob
Raws li guanosine analog, 2, {{{1} dideoxyguanine 丨 cas}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Pab rau kev tsim cov tshuaj kom rov qab nrog kev ua tau zoo dua thiab qis toxicity.
3. Tshuaj Kho Mob
Lub molecule muaj cov qauv txheej txheem rureats uas tso cai kho lub hauv paus lossis qab zib los txhim kho cov kws muag tshuaj ua haujlwm, ruaj khov, lossis hom phiaj. Qhov no yog qhov muaj txiaj ntsig zoo nyob rau hauv kev tsim muaj zog ntawm nucleoside-raws li kev kho mob.
4. Kev tshawb nrhiav profile
Kev kawm seb cov kab mob tsim tawm mus li cas rau Guanosine analogs zoo li 2, {

2? Nws lub peev xwm yuav tsum tso tseg DNA thiab RNA chains los ntawm cov nucleosides ua rau nws cov tshuab tshawb fawb thiab txhim kho cov khoom siv tom ntej no. Txawm hais tias nws tsis yog dav siv los ua cov tshuaj sawv ntsug, nws cov nqi hluav taws xob ua cov scaffold thiab biochemical cov cuab yeej ua kom pom kev txuas ntxiv rau hauv kev kawm thiab kev tshawb fawb kev tshawb fawb.