Cov lus qhia
| Zog: | Tawm-dawb lossis dawb hmoov |
| Purity (HPLC): | 98% min |
| TLC: | Ob qhov chaw |
| Tshuaj Clarity Xeem: | Meej |
| 31P NMR Purity: | 98% min |
| Cov ntsiab lus dej: | 0.5% max |
Cov Ntawv Thov
1. Khoom-theem oligonucleide syncheside
Enables qhov chaw-sports concorporation ntawm 2'-f-dg rau hauv hluavtaws oligonucleides.
Tau tshaj nrog cov khoom siv hluav taws xob hluavtaws hluav taws xob rau kev tsim cov chaw RNArically Stretchized RNA / DNA cov hybrids.
2. RNA HHNAPEUTICS KEV LOJ
Dav siv nyob rau hauv:
sirna (cuam tshuam rau kev cuam tshuam me me)
Antisense Oligonucleides (Asos)
RNA Aptamers
Txhim kho cov roj ntsha ib nrab-lub neej thiab kev sib tsoo sib txawv hauv vivo, txhim kho kho lub peev xwm.
3. Cov qauv thiab kev ua haujlwm RNA kev tshawb fawb
Mimics ntuj RNA qauv thaum tso cai kawm RNNA-protein kev sib cuam tshuam, enzymatic kev ua si nyob rau hauv cov kev mob biologically.
4. Kev kuaj xyuas cov ntawv thov
Thov siv rau hauv kev tsim ntawm high-affinity nucleic acid probes rau qpcr, ntses, thiab biosensors qhov twg txhim kho hybrid stability yog qhov tseem ceeb heev.
Cov txiaj ntsig
✔ Ntau zuj zus
Cov tshuaj 2 uas fluoro uas muaj cov roj ntsha uas tsis muaj teeb meem, muab kev txhim kho tseem ceeb hauv oligo stability, tshwj xeeb tshaj yog nyob rau hauv dej hiav txwv lossis intracellular ib puag ncig.
✔ Tau txais hybridization cov yam ntxwv
2'-f hloov kho nce thermal ruaj khov (tm) thiab khi lub zog, txhim kho tshwj xeeb rau cov hom phiaj RNA lossis DNA ua ntu zus.
✔ qis dua impunogenicity
Hloov kho oligonucleArit cov kev nthuav dav Oligonucleots Kev nthuav tawm ntawm Innate Recors, xws li hul-zoo li cov recapors (tlrs), ua rau lawv haum rau kev kho cov tshuaj.
✔ Kev ua suab hluavtaws muaj txiaj ntsig zoo
Kev tiv thaiv pab pawg (N-iBu thiab ced) pab ntxuav, high-reprthesis nrog kev ua tau zoo tshaj plaws hauv kev siv hluav taws xob synthesis raws.
✔ RNA-li tus cwj pwm
Kev koom tes ntawm 2'-f-dg rau oligos tsim RNA ua ke nrog DNA nraub qaum ruaj khov, ua rau lawv muaj txiaj ntsig hauv RNA mimicry thiab hybrid.
Tag
2'-fluoro-2'-deoxyguanosine (N-ibu) ced phosphoramidite (CAS 14'-fluoro-hloov kho cov roj ntsha oligonucle-m) yog cov txiaj ntsig Nws yog cov cuab yeej tseem ceeb hauv RNA kev cuam tshuam, kev kho mob molecular, thiab cov molecular kev kuaj mob, muab kev tiv thaiv tsis zoo, txo cov kev tiv thaiv kev tiv thaiv, thiab cov synthesia ua tau zoo. Qhov zoo tagnrho rau kev nce qib OligonucleA raws li kev txhim kho yeeb tshuaj thiab kev tshawb nrhiav RNA.
Cim npe nrov: 2-fluoro-2-Doxy Guanosine (NBU) Ced Phosphoramidation 丨 Cas 144089-97-4 Cas 144089-97-4 Kws Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas
