Khoom Taw Qhia
ADC Linkers (Antibody-Drug Conjugate Linkers) yog cov khoom siv tshuaj lom neeg tseem ceeb siv hauv kev txhim kho Antibody-Drug Conjugates (ADCs), ib chav kawm ntawm kev kho mob qog noj ntshav. ADCs muab qhov tshwj xeeb ntawm cov tshuaj tiv thaiv monoclonal nrog lub zog ntawm cov tshuaj cytotoxic, ua rau lub hom phiaj xa cov tshuaj ncaj qha mus rau cov qog nqaij hlav cancer thaum txo qis kev puas tsuaj rau cov hlwb noj qab haus huv. Tus linker ua lub luag haujlwm tseem ceeb hauv cov txheej txheem no, txuas cov tshuaj tiv thaiv kab mob rau cov tshuaj thiab ua kom ntseeg tau tias cov tshuaj tswj tau tso tawm hauv cov hlwb. Kev tsim thiab kev ua haujlwm ntawm ADC txuas txuas yog qhov tseem ceeb rau kev nyab xeeb, kev ua tau zoo, thiab kev ruaj ntseg ntawm ADCs, ua rau lawv yog ib qho tseem ceeb hauv kev kho mob qog noj ntshav niaj hnub no.
Product Advantages Thiab Features
Targeted Drug Delivery
ADC linkers tso cai rau kev xa cov tshuaj cytotoxic rau cov qog nqaij hlav cancer, txo qhov kev puas tsuaj rau cov hlwb.
Tswj Kev Tso Tshuaj
Nyob ntawm hom linker, cov tshuaj tso tawm tuaj yeem tshwm sim los ntawm cov xwm txheej tshwj xeeb hauv thaj chaw mob qog noj ntshav, kom ntseeg tau tias cov tshuaj tso tawm tsuas yog thaum xav tau.
Txhim khu kev ua tau zoo
Los ntawm kev txhim kho lub zog ntawm cov tshuaj ncaj qha mus rau lub hom phiaj, ADC txuas ntxiv txhim kho tag nrho cov txiaj ntsig ntawm kev kho mob.
Yam tsawg kawg nkaus
Txij li thaum ADC linkers txo - lub hom phiaj tso tshuaj, cov neeg mob muaj kev phiv tsawg dua piv rau cov tshuaj chemotherapy.
Txhim khu kev ruaj ntseg
Niaj hnub no ADC linkers xyuas kom meej tias cov tshuaj tseem txuas nrog rau cov tshuaj tiv thaiv kab mob thaum lub sij hawm ncig, tiv thaiv kev tso tshuaj ntxov ntxov thiab ua kom cov tshuaj mus txog nws lub hom phiaj.
Ntau yam Tsim
ADC txuas tuaj yeem tsim kho rau cov tshuaj sib txawv thiab cov tshuaj tiv thaiv kab mob, tso cai rau ntau yam kev siv hauv kev kho mob qog noj ntshav.
Yam khoom
Cov kev sib txuas no yog tsim los tso cov tshuaj hauv cov lus teb rau cov kab mob hauv lub cev xws li pH qis, muaj cov enzymes (proteases), los yog txo qhov chaw (glutathione). Cleavable linkers xyuas kom cov tshuaj tso tawm tsuas yog nyob rau hauv lub hom phiaj hlwb. Cov hom muaj xws li:
• Acid-labile linkers: Ua rau cov tshuaj tso tawm hauv cov acidic ib puag ncig zoo li cov pom hauv lysosomes.
• Disulfide linkers: rhiab heev rau txo cov neeg ua haujlwm hauv cytosol ntawm cov qog nqaij hlav cancer.
• Peptide-raws li linkers: Cleaved los ntawm tej enzymes overexpressed nyob rau hauv cov qog hlwb.
Cov linkers no khaws cov tshuaj txuas mus rau cov tshuaj tiv thaiv kab mob kom txog thaum cov tshuaj tiv thaiv degraded hauv lub cell. Cov tshuaj tsuas yog tso tawm tom qab tag nrho ADC tawg lawm. Tsis yog- cov kab txuas uas tsis tuaj yeem muab kev ruaj ntseg ntau dua hauv kev ncig thiab tsis tshua muaj peev xwm ua rau tawm - lub hom phiaj toxicity.
Cov linkers no txhim kho cov solubility ntawm ADC, txhim kho nws cov kev faib tawm thiab txo qhov kev pheej hmoo ntawm kev sib sau ua ke, uas tuaj yeem ua rau txo qis kev ua tau zoo thiab nce kev tiv thaiv kab mob.
Siv thaum xav tau kev txuas ruaj khov dua, cov kev sib txuas no tuaj yeem txhim kho txoj kev sib raug zoo ntawm cov tshuaj thiab cov tshuaj tiv thaiv kab mob, txhim kho kev ua tau zoo tag nrho.
Tsim los rau cov ntawv thov tshwj xeeb uas yuav tsum muaj kev tswj hwm kev tso tawm cov tshuaj, cov txuas txuas no tsuas yog qhib los ntawm tsis yog - haiv neeg biochemical cov tshuaj tiv thaiv hauv lub hom phiaj ib puag ncig.
Daim Ntawv Thov Cov Khoom
ADC linkers yog qhov tseem ceeb rau cov ntawv thov hauv qab no:
Kev Kho Mob Cancer
ADCs feem ntau yog siv hauv oncology kom xa cov tshuaj cytotoxic ncaj qha rau cov qog nqaij hlav cancer, txo cov kab mob toxicity feem ntau cuam tshuam nrog kev kho mob.
Tshuaj kho tus kheej
ADC linkers pab txhim kho cov kev kho mob uas haum rau ib tus neeg mob cov kab mob qog noj ntshav, tso cai rau cov tswv yim kho mob zoo dua thiab tus kheej.
Kev Txhim Kho Tshuaj
ADC linkers yog lub hom phiaj tseem ceeb hauv kev tshawb fawb tshuaj thiab kev tsim kho raws li cov kws tshawb fawb nrhiav los tsim cov tshuaj sib txuas zoo dua nrog cov tshwj xeeb thiab muaj zog.
Immunotherapy
ADC linkers ua lub luag haujlwm hauv kev sib txuas cov tshuaj xa mus nrog cov tshuaj tiv thaiv kab mob, txhim kho lub cev tiv thaiv kab mob tiv thaiv kab mob qog noj ntshav.
Combination Therapies
ADCs nrog cov txuas tshwj xeeb tuaj yeem siv ua ke nrog lwm yam kev kho mob, xws li kev kho hluav taws xob lossis kev tiv thaiv kab mob, txhawm rau txhim kho kev kho mob tag nrho.
Lub hom phiaj xa khoom ntawm Lwm Cov Kev Kho Mob
Tshaj li mob qog noj ntshav, ADC txuas tau raug tshawb fawb txog kev xa cov tshuaj hauv cov kab mob autoimmune thiab lwm yam mob uas cov phiaj xwm kho tau zoo.
Khoom Siv Khoom
ADC linkers yog tsim los ntawm kev sib xyaw ua ke ntawm cov organic molecules thiab cov pab pawg tshuaj tsim los ua kom muaj kev cuam tshuam thiab ruaj khov nrog cov tshuaj tiv thaiv thiab tshuaj:
PEG (Polyethylene Glycol):Siv nyob rau hauv hydrophilic linkers los txhim kho solubility thiab txo immunogenicity.
Disulfide Bonds:Feem ntau nyob rau hauv cleavable linkers, cov ntawv cog lus no rhiab heev rau txo cov xwm txheej hauv lub hom phiaj hlwb.
Peptide Sequences:Tsim los kom cleaved los ntawm tej enzymes, feem ntau siv nyob rau hauv peptide -raws li cleavable linkers rau daim ntaub ntawv mob cancer.
Acid{0}}labile Pawg:Incorporated rau hauv linkers uas tso tshuaj nyob rau hauv acidic ib puag ncig zoo li endosomes thiab lysosomes.
Hydrazones:Cov pab pawg ua haujlwm uas ruaj khov ntawm nruab nrab pH tab sis cleaved nyob rau hauv acidic tej yam kev mob, ua rau lawv haum rau qog- phiaj siv.
Spacer Molecules:Xws li kom deb ntawm cov tshuaj los ntawm cov tshuaj tiv thaiv kab mob, txo qis steric hindrance thiab xyuas kom raug khi thiab tso tawm.
Cov txheej txheem ntau lawm lossis txheej txheem
Kev tsim khoom ntawm ADC txuas yuav tsum muaj cov khoom sib xyaw ua ke thiab cov tshuaj lom neeg zoo, vim lawv yuav tsum muaj qhov tshwj xeeb thiab ruaj khov:
Precise Synthesis
ADC linkers yog crafted los ntawm kev tswj cov organic synthesis cov tswv yim los xyuas kom meej cov qauv tshuaj thiab kev ua haujlwm.
Kev Tswj Xyuas Zoo
Txhua pawg ntawm ADC txuas tau dhau los ua qhov kev sim nruj rau kev ua kom huv, rov ua haujlwm, thiab ruaj khov kom ntseeg tau tias lawv ua tau raws li qhov xav tau thaum sib txuas rau cov tshuaj tiv thaiv thiab tshuaj.
Kev kuaj kev ruaj ntseg
ADC linkers raug sim nyob rau hauv ntau yam physiological tej yam kev mob (xws li, pH, enzymatic raug) los xyuas kom meej tias lawv nyob ruaj khov thaum lub sij hawm ncig thiab tsuas tso cov tshuaj nyob rau hauv lub hom phiaj ib puag ncig.
Conjugation Optimization
Cov txheej txheem ntawm kev sib txuas cov tshuaj mus rau cov tshuaj tiv thaiv kab mob los ntawm kev sib txuas yog ua tib zoo ua kom zoo dua los ua kom cov tshuaj them nyiaj ntau tshaj plaws thiab txo qis kev cuam tshuam nrog cov tshuaj tiv thaiv lub peev xwm.
Cheebtsam ntawm Cov Khoom
Antibody Binding Site
Qhov kawg ntawm tus linker uas txuas rau cov tshuaj tiv thaiv kab mob monoclonal, tsim kom muaj kev ruaj khov thiab tsis muaj - cuam tshuam rau cov tshuaj tiv thaiv kev ua haujlwm.
Tshuaj Txhaum Cai
Cov seem ntawm cov linker uas txuas mus rau cov tshuaj cytotoxic, feem ntau tsim los tso cov tshuaj nyob rau hauv tej yam kev mob nyob rau hauv lub hom phiaj hlwb.
Spacer
Cov qauv tshuaj uas cais cov tshuaj thiab cov tshuaj tiv thaiv kab mob, txo cov kev cuam tshuam steric thiab ua kom cov tshuaj tso tawm kom raug.
Cleavable / Tsis yog -Cleavable Bond
Nyob ntawm hom linker, daim ntawv cog lus no txiav txim seb yuav ua li cas thiab thaum twg cov tshuaj tso tawm, kom ntseeg tau tias tus me nyuam hauv cov qog nqaij hlav cancer.
Cov pab pawg ua haujlwm
Cov pab pawg tshuaj tshwj xeeb uas tso cai rau kev xaiv qhov txuas ntawm qhov txuas mus rau cov tshuaj tiv thaiv kab mob thiab tshuaj tsis cuam tshuam rau lawv cov qauv.
Cov khoom tu thiab ceev faj
ADC txuas yuav tsum tau muab cia rau hauv qhov chaw txias, qhuav kom tsis txhob muaj kev puas tsuaj ntxov ntxov. Kev sau cov thawv ntim khoom kom raug yog qhov tseem ceeb los xyuas kom muaj kev tuav tau zoo.
Tsis tu ncua xyuas lub txee lub neej ntawm ADC txuas kom ntseeg tau tias lawv tswj tau lawv cov kev ruaj ntseg thiab kev ua tau zoo nyob rau lub sijhawm.
Hnav cov cuab yeej tiv thaiv tus kheej tsim nyog (PPE) thaum tuav ADC txuas, vim lawv feem ntau nkag siab rau cov dej noo thiab kub hloov.
Ua ntej conjugation, ua cov kev ntsuam xyuas kom ntseeg tau tias tus linker tau sib xws nrog cov tshuaj tiv thaiv tshwj xeeb thiab cov tshuaj siv hauv ADC formulation.
Cov kev kuaj xyuas zoo niaj hnub yog qhov tseem ceeb los xyuas kom meej tias ADC cov neeg sib txuas tswj hwm lawv cov tshuaj lom neeg ncaj ncees thaum khaws cia thiab tuav.
Lub tuam txhab zoo
Peb tsom rau kev ua tau zoo & Kev paub ntawm cov neeg siv khoom
Peb mob siab rau kev xa cov khoom zoo - cov khoom zoo thiab cov neeg siv khoom tshwj xeeb tshaj qhov koj xav tau.
Comprehensive Product Range
Cov ntawv teev lus dav dav ntawm ntau dua 27,000 cov tshuaj rau ntau hom kev lag luam, muab ob qho tib si cov qauv sib xyaw thiab cov kev daws teeb meem tshwj xeeb.
Strong Industry Expertise
Peb pab neeg muaj kev paub ntau yam muab kev cob qhia kws tshaj lij, nyob nrog kev lag luam tam sim no kom xa cov tshuaj zoo tshaj plaws raws li koj xav tau.
Competitive Pricing & Reliability
Cov nqi sib tw thiab kev xa khoom tuaj yeem ua kom ntseeg tau tias tus nqi- muaj txiaj ntsig zoo, cov khoom siv tau zoo yam tsis muaj kev cuam tshuam zoo.
Yuav Ua Li Cas Koom Tes Nrog Peb
Kev koom tes nrog LEAPChem muab rau koj nkag mus rau cov kws tshaj lij ntawm lub tuam txhab ua lag luam nrog 18 xyoo ntawm kev paub hauv kev lag luam tshuaj. Peb muab ntau tshaj 27,000 chemical tshuaj raws li kev xav tau ntau yam. Tag nrho peb cov khoom ua raws li cov qauv kev lag luam thiab nrog rau cov ntawv pov thawj tsim nyog.
Peb koom tes nrog ntau tus neeg koom tes, suav nrog:
• Cov chaw soj ntsuam tshawb fawb
• Cov Tuam Txhab Tshuaj
• Cov kws tsim tshuaj pleev ib ce
• Cov Khoom Siv Hluav Taws Xob
• Cov Chaw Tsim Tshuaj
• Cov Tsev Kawm Ntawv Qib Siab thiab Tsev Kawm Qib Siab Thoob Ntiaj Teb
• Thiab ntau dua.
Peb tshwj xeeb hauv kev pab peb cov neeg siv khoom kom pom cov tshuaj lom neeg zoo raws li lawv cov kev xav tau tshwj xeeb. Tsis tas li ntawd, peb muab cov kev pabcuam sib xyaw ua ke kom tau raws li cov kev xav tau tshwj xeeb ntawm peb cov neeg koom tes. Txawm hais tias koj xav tau ntau npaum li cas rau cov txheej txheem kev lag luam lossis cov khoom me me rau cov ntawv thov tshwj xeeb, peb tau txais koj them.
Yog tias koj tab tom nrhiav ib tus neeg muag khoom tshuaj lom neeg, peb yuav zoo siab tau hnov los ntawm koj. Thov xa koj cov lus nug lossis cov lus qhia txog qhov project rau sales@leapchem.com. Peb pab neeg ua haujlwm tau mob siab koom tes nrog koj thiab pab ua tiav koj lub hom phiaj.
FAQ
Q: Dab tsi yog ADC txuas?
A: ADC linkers yog cov tshuaj sib txuas uas txuas cov tshuaj tiv thaiv kab mob rau cov tshuaj cytotoxic hauv Antibody -Drug Conjugates (ADCs), kom ntseeg tau cov tshuaj xa mus.
Q: Vim li cas ADC linkers tseem ceeb hauv kev kho mob qog noj ntshav?
A: ADC linkers pab kom xa cov kab mob qog noj ntshav muaj zog- tua cov tshuaj ncaj qha rau cov qog nqaij hlav cancer, txo qis kev puas tsuaj rau cov nqaij mos noj qab haus huv thiab txo cov kev mob tshwm sim.
Q: Dab tsi yog qhov txawv ntawm cleavable thiab non{0}}cleavable linkers?
A: Cleavable linkers tso tawm cov tshuaj nyob rau hauv teb rau tej yam kev mob nyob rau hauv cov qog nqaij hlav cancer, thaum uas tsis yog -cleavable linkers xav kom tag nrho ADC degraded nyob rau hauv lub cell rau cov tshuaj tso tawm.
Q: Lub cleavable linker ua haujlwm li cas?
A: Cleavable linkers tso tawm cov tshuaj cytotoxic thaum lawv ntsib qee yam mob hauv lub cev, xws li pH qis lossis muaj qee yam enzymes.
Q: Puas yog ADC txuas txuas ruaj khov thaum lub sijhawm ncig?
A: Yog lawm, ADC txuas niaj hnub no yog tsim los kom ruaj khov thaum lub sijhawm ncig, tsuas yog tso cov tshuaj ib zaug hauv cov phiaj hlwb.
Q: Cov ntaub ntawv dab tsi yog siv los ua ADC txuas?
A: ADC linkers yog tsim los ntawm kev sib xyaw ntawm cov organic molecules, suav nrog disulfide bonds, peptides, hydrazones, thiab spacer molecules.
Q: Yuav ua li cas tsis yog -cleavable linkers tso cov tshuaj?
A: Tsis yog- cov kab sib txuas uas tsis tuaj yeem tso tawm cov tshuaj thaum tag nrho ADC tawg hauv lub hom phiaj ntawm tes, ua kom muaj kev ruaj ntseg ntau dua hauv cov hlab ntsha.
Q: Dab tsi yog lub luag haujlwm ntawm spacer molecules ua si hauv ADC txuas?
A: Spacer molecules nyob deb ntawm cov tshuaj los ntawm cov tshuaj tiv thaiv kab mob, tiv thaiv kev cuam tshuam nrog cov tshuaj tiv thaiv kab mob thiab ua kom cov tshuaj tso tawm kom raug.
Q: ADC txuas tuaj yeem hloov kho?
A: Yog lawm, ADC txuas tuaj yeem tsim kho rau cov tshuaj tiv thaiv tshwj xeeb, tshuaj, thiab tso tawm cov xwm txheej, ua rau lawv muaj ntau yam hauv cov phiaj xwm kev kho mob.
Q: Yuav ua li cas yog ADC txuas txuas rau kev ruaj ntseg?
A: ADC cov neeg txuas tau dhau los kuaj kev ruaj ntseg hauv ntau lub cev kom ntseeg tau tias lawv ua tau raws li qhov xav tau thaum kho.
Q: Puas yog ADC linkers txo cov kev mob tshwm sim hauv kev kho mob qog noj ntshav?
A: Yog lawm, los ntawm kev ua kom cov tshuaj cytotoxic tsuas yog tso tawm hauv cov qog nqaij hlav cancer xwb, ADC linkers txo - lub hom phiaj toxicity thiab txo cov kev mob tshwm sim.
Q: Puas muaj lwm daim ntawv thov rau ADC txuas ntxiv rau kev kho mob qog noj ntshav?
A: Thaum siv feem ntau hauv oncology, ADC txuas kuj tseem raug tshawb fawb rau kev xa tawm hauv cov kab mob autoimmune thiab lwm qhov chaw kho mob.
| CAS Nr. | Khoom npe | ||
| Tsis yog -Cleavable Linker | |||
| 71875-81-5 | SMCC | ||
| 64987-85-5 | SMCC | ||
| 103750-03-4 | 5-Maleimidovalericacid-NHS | ||
| 80307-12-6 | GMBS | ||
| 55750-63-5 | EMCS | ||
| 55750-61-3 | N-SMP | ||
| 756525-99-2 | Mal-DPEG4-NHS | ||
| 1334177-86-4 | Mal-amido-PEG8-acid | ||
| 1599472-25-9 | Mal-PEG6-NHS ester | ||
| 1537892-36-6 | Mal-PEG3-NHS ester | ||
| 1807534-78-6 | Mal-PEG3-PFP ester | ||
| 1008402-79-6 | Bis(NHS)PEG 9 | ||
| 756526-03-1 | Bis(NHS)PEG5 | ||
| 1314378-11-4 | NHS-PEG3-NHS | ||
| 1314378-16-9 | Bis -PEG3-NHS Ester | ||
| 65869-63-8 | Bis -PEG2-NHS Ester | ||
| 65869-64-9 | Bis -PEG1-NHS ester | ||
| 1312309-64-0 | Azido-PEG2-NHS ester | ||
| 478801-48-8 | 5-azidopentanoic acid N-hydroxysuccinimide ester | ||
| 943858-70-6 | succimimidyl-4-azidobutyrate | ||
| 824426-32-6 | NHS-Ac-N3 | ||
| 1421932-52-6 | endo-BCN-PEG4-PFP ester | ||
| 1421932-53-7 | endo-BCN-PEG2-PFP ester | ||
| 1425803-45-7 | 2,5-dioxopyrrolidin-1-yl 2-(cyclooct-2-ynyloxy)acetate | ||
| 1428629-70-2 | Propargyl-PEG4-NHS ester | ||
| 906564-59-8 | 5-hexynoic NHS ester | ||
| 132178-37-1 | 4-pentynoic acid succinimidyl ester | ||
| 1347750-81-5 | MAL-Di-EG-OPFP | ||
| 1263044-56-9 | Mal-PEG10-NHS | ||
| 1137109-22-8 | Maleimide-NH-PEG10-CH2CH2COONHS Ester | ||
| 756525-93-6 | Mal-PEG8-NHS | ||
| 1137109-21-7 | Mal-PEG6-NHS | ||
| 1315355-92-0 | Mal-PEG5-NHS | ||
| 1347750-84-8 | Maleimide-NH-PEG4-CH2CH2COOPFP Ester | ||
| 955094-26-5 | Mal-PEG2-NHS | ||
| 1260092-50-9 | Mal-PEG-NHS | ||
| 1415800-42-8 | Mal-PEG4-PFP | ||
| 1325208-25-0 | Mal-PEG4-NHS | ||
| 1807512-47-5 | Mal-PEG2-PFP | ||
| 1433997-01-3 | Mal-PEG2-NHS | ||
| Cleavable Linker (Chemically-Cleavable) | |||
| Acid{0}}Cleavable | |||
| 65623-82-7 | 4-(4-Acetyl-phenoxy)-butyric acid | ||
| 60444-78-2 | 2,5-dioxopyrrolidin-1-yl 4-formylbenzoate | ||
| 1309460-27-2 | Ald-Ph-PEG4-acid | ||
| 1007215-91-9 | Ald-Ph-PEG3-acid | ||
| 1061569-06-9 | Ald-Ph-PEG2-acid | ||
| 1007215-94-2 | tert -butyl 1-(4-formylphenyl)-1-oxo-5,8,11-trioxa-2-azatridecan-13-oate | ||
| 1245813-70-0 | tert -butyl 1-(4-formylphenyl)-1-oxo-5,8,11,14,17,20,23,26,29,32,35-undecaoxa-2-azaheptatriacontan-37-ylcarbamate | ||
| 1337889-01-6 | N-(35-amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)-4-formylbenzamide | ||
| 1324007-10-4 | Ald-PEG4-PFP | ||
| 1353011-74-1 | Ald-PEG4-NHS ester | ||
| 1807521-07-8 | Ald-Ph-PEG2-NHS | ||
| Reductive -Cleavable | |||
| 68181-17-9 | SPDP | ||
| 890409-85-5 | 2,5-dioxopyrrolidin-1-yl 4-methyl-4-(pyridin-2-yldisulfanyl) pentanoate | ||
| 874302-76-8 | 4-nitrophenyl 2-(pyridin-2-yldisulfanyl) ethyl carbonate | ||
| 1252257-56-9 | SPDP-PEG8-NHS | ||
| 1305053-43-3 | Pyridin -2-yldisulfanyl-PEG4-NHS | ||
| 1824718-79-7 | N-succinimidyl-6-(2-pyridyldithio)capronate | ||
| 317331-86-5 | N-succinimidyl-5-(2-pyridyldithio)valerate | ||
| 663598-98-9 | 2,5-dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl) pentanoate | ||
| 1193111-39-5 | 1-(2,5-dioxopyrrolidin-1-yloxy)-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid | ||
| 663598-85-4 | N-succinimidyl 4-(5-nitro-pyridin-2-yldithio)-pentanoate | ||
| 107348-47-0 | 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate | ||
| 160580-70-1 | Perfluorophenyl 3-(pyridin-2-yldisulfanyl) propanoate | ||
| 121115-30-8 | 2,5-dioxo-1-(3-(pyridin-2-yldisulfanyl)propanoyloxy)pyrrolidine-3-sulfonic acid | ||
| 1610769-13-5 | 4-((S)-2-((S)-2-amino-3-methylbutanamido)-5-ureidopentanamido)benzyl 2-(pyridin-2-yldisulfanyl)ethylcarbamate | ||
| Cleavable Linker (Enzyme-Cleavable) | |||
| Cathepsin Cleavable | |||
| 159857-81-5 | Mc-Val-Cit-PABC-PNP | ||
| 159857-79-1 | Val-cit-PAB-OH | ||
| 159858-22-7 | Fmoc-Val-Cit-PAB | ||
| 863971-53-3 | Fmoc-Val-Cit-PAB-PNP | ||
| 2149584-03-0 | Phe-Lys(Fmoc)-PAB | ||
| 1116085-99-4 | Phe-Lys(Trt)-PAB | ||
| 1160844-44-9 | Boc-Ph-(Alloc)Lys-PAB-PNP | ||
| 159857-90-6 | Cbz-Ph-(Alloc)Lys-PAB-PNP | ||
| 253863-34-2 | Aloc-D-Ala-Ph-Lys(Aloc)-PAB-PNP | ||
| 1116086-09-9 | Fmoc-Ph-Lys(Trt)-PAB-PNP | ||
| Fmoc-Gly3-Val-Cit-PAB-OH | |||
| Fmoc-Gly3-Val-Cit-PAB-PNP | |||
| Mc-Val-Cit-PABC-Diamine | |||
| Mc-PEG2-Val-Cit-PAB | |||
| DBCO-Val-Cit-PAB | |||
| Glycosidase -Cleavage | |||
| -Glucuronic-PAB | |||
| -Glucuronic-PAB-PNP | |||
| -Galactose-PAB-PNP | |||
| Lwm yam kev sib txuas | |||
| 142356-33-0 | 6 -(Boc-amino) hexyl bromide | ||
| 622405-78-1 | m-PEG4-NHS ester | ||
| 1025796-31-9 | (S)-di-tert-butyl 2-(3-((S)-6-amino-1-tert-butoxy-1-oxohexan-2-yl)ureido)pentanedioate | ||
| 1026987-94-9 | (S)-5-tert-Butoxy-4-(3-((s)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic Acid | ||
| 1127247-34-0 | m-PEG2-NHS ester | ||
| Linker Payload | |||
| 169869-90-3 | Exatecan Mesylate | ||
| 171335-80-1 | Exatecan | ||
| 1599440-33-1 | DXD | ||
| 66584-72-3 | Ansamitocin P-3 | ||
| 57103-68-1 | Ansamitocin P-0 | ||
| 139504-50-0 | DM 1 | ||
| 796073-69-3 | DM 4 | ||