Tert-butyl 4- (6-aminopyridin-3-yl) piperazine-1-carboxylate 丨 CAS 571188-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59

Khoom Taw qhia:

Catalog tsis muaj.: SS130363
CAS TSIS MUAJ .: 571188-59-59-5
Assay: 98.5% min
Cov Khoom Npe: Tert-Butyl 4- (6-aminopyridin-3-YL) Piperazine-1-Carboxylate
Molecular cov mis: c14h22n4o2
Molecular hnyav: 278.35

Xa kev nug

Kev tsis

Hauj lwm lawm

Cov lus qhia

Zog:	Lub teeb daj rau cov hmoov av xim av
Assay:	98.5% min
Yam khoom:
Impurity a:	0.15% Max
Ipurity B:	0.15% Max
Tus neeg Impurity:	0.5% max
Tag nrho cov impurities:	1.5% Max
Poob rau ziab:	0.5% max

Cov Ntawv Thov

1. Tshuaj Nruab Nrab

Qhov sib txuas no feem ntau yog siv nyiaj nruab nrab lossis lub tsev uas muaj cov tshuaj chemistry, tshwj xeeb tshaj yog rau:

Kinease Inhibitor Kev Loj Hlob

Neurophartets Cov Phiaj Xwm CNS Txoj Kev

Anti-cancer Cov neeg sawv cev raws li Pyridine-Piperazine Scaffolds

Lub BOC-tiv thaiv amine thiab heterocyclic hloov kev kawm ua rau nws haum rau combinatorial chemistry thiab SAR (qauv-kev sib raug zoo) kev tshawb nrhiav.

2. Fridment hauv kev tshawb tshuaj yeeb

Nws yog qhov kev cai tshwj xeeb hauv kev ua yeeb yam tshuaj yeeb (FBDD) thiab ua rau kev ua kom ua tau zoo.

Feem ntau pom nyob rau hauv molecules hom phiaj:

Tus gpcrs

Ion Raws

Enzyme inibitors, tshwj xeeb tshaj yog koom nrog PI3K, mtor, lossis Kinase Lomains.

3. Heterocyclic Scaffold nyob rau hauv cov tebchaw bioaction

Lub nplhaib pyridine ua kom tau txais kev sib txuas lus zoo thiab muab cov kev sib cuam tshuam rau kev sib txuas lus sib txuas lus rau kev sib txuas lus sib txuam nrog kev siv roj ntsha.

Piperazine Moamety pab rau:

Nce solubility

Txhim Kho Cov Tshuaj-Zoo

Yooj yooj yim hauv kev sib txuas rau lwm yam kws muag tshuaj

4. Tshuaj Synthesis

Nws yog qhov hluav taws xob hluav taws xob muaj txiaj ntsig hauv kev npaj ntawm:

Multifunctional ligands

HeterCovatic derivatives

Bioconjugates siv nyob rau hauv cov tshuaj kho cov tshuaj lossis kuaj mob

Cov txiaj ntsig

1. BOC kev tiv thaiv nce versatility

Lub Tert-Butyl carbamate (BOC) Pawg:

Tiv thaiv piperazine nitrogen thaum lub sij hawm ntau-kauj ruam

Tuaj yeem muab tau yooj yim tshem tawm hauv cov mob acidic me me (piv txwv li, pub rau kev xaiv tsis txaus thiab ua haujlwm

2. Txhim Kho Cov Khoom Siv Hluav Taws Xob

Kev sib xyaw ntawm HeterComatic (Pyridine) thiab Piperazine pawg yog paub rau:

Txhim kho qhov ncauj ntawm qhov ncauj

Txhawb BBB (Ntshav-Lub Hlwb Barrier) Kev Nkag

Nce metabolic ruaj khov

3. Modular tsim los rau kev tsim cov tshuaj

Tus qauv tsim tawm yooj yim hloov kho ntawm ntau cov ntsiab lus:

Cov pab pawg AMine ntawm lub nplhaib pyridine tuaj yeem ua tau acylated, sulgonylated, lossis hloov dua siab tshiab rau heterocycles.

Boc-Piperazine tuaj yeem ua kom sib txawv kom muab lwm cov kws muag tshuaj lossis cov ntawv txuas.

Qhov no ua rau nws zoo tshaj rau cov tsev qiv ntawv tiam nyob rau hauv high-topputure kuaj (HTs).

4. Cov hluavtaws siab tawm & kev lag luam muaj

Cov compound muaj nyob rau ntawm siab huv thiab yog qhov ruaj khov nyob rau hauv cia.

Haum rau kev sib tw-nyob hauv cov tshuaj chemical network thiab txheej txheem kev txhim kho.

Tag

TERT-Butyl 4- (6-aminopyridin-3-YL) Piperazine-tshwj xeeb rau kev tsim cov tshuaj Kinase inhibitors, CNS-nquag tshuaj, thiab tshuaj tiv thaiv mob qog nqaij hlav cancer. Nws cov qauv sib luag, muaj cov amino amino pyridazine, thiab pab pawg boc, muab cov khoom siv hluavtaws, muab cov khoom siv hluavtaws thiab cov khoom siv hluav taws xob. Nws yog lub tsev uas muaj kev ua kom muaj tshuaj lom neeg rau cov tshuaj niaj hnub no rau cov muaj kev sib xyaw ua ke, cov khoom sib xyaw Heterocclic sib xyaw.

Cim npe nrov: tert-butyl 4- (6-aminopyridin-3-yl) piperazine-1-yl) piperazine-(6-tus tsiaj)