2,3,4,5-tetrahydro-7,8-dinitro-3- (Methanoacetyl) -1,5-METANOANETSYR)-1H-Benzazepine 丨 CAS 230615-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59-59

Tshuaj Lom Zem

2,3,4,5-tetrahydro-7,8-dinitro-3- (Methanoacetyl) -1,5-Methano-1H-Benzaurine-1-Benzazepine 丨 CAS 230615-59-59 yog aSiab ua haujlwm Trricycle benzazepine derivative, tsim nrog electron-rho tawm pawg (nitro, trifluoroacetyl) thiab lub zog siv hluav taws xob ntau feem ntau cuam tshuam nrog cov ntaub ntawv sib txawv lossis cov ntaub ntawv siab.

Cov Ntawv Thov

1. Kev Tshawb Fawb (Cov Tshuaj Ntsuam Xyuas Kev Loj Hlob)

TusBenzazepine ScaffoldTau kawm dav hauv cov tshuaj chemistry rau nws lub hlwb hauv nruab nrab (CNS) kev ua si.

Cov neeg hloov chaw zoo liNitro PawgthiabTrifluoroacetylMoeties yog paub los txhim khoreceptor bindingthiablipophilicity, tej zaum yuav ua kom muaj ntshav thaiv cov ntshav permeability.

Xws li cov tebchaw yuav raug tshuaj xyuas raws liCov kws kho mob tau txais cov modulators, enzyme inibitors, lossisAnti-inflammatory tus neeg sawv cev, Txawm hais tias cov ntaub ntawv tshwj xeeb rau ntawm no molecule yog txwv.

2. Tshuaj Ntsuam Xyuas & Lead Optimization

Vim nwsElectron-nplua nuj thiab selically ua qauv, nws tuaj yeem ua haujlwmtus kemRau sar (qauv-kev sib raug zoo) kev tshawb fawb hauv kev tshuaj pom tshuaj.

Pab tau hauv kev tshawb nrhiavtshuaj-zoo li khoom sivthiab metabolic stability, tshwj xeeb hauv cov tshuaj fluorine tshwj xeeb.

3. Cov Khoom Siv Kev Tshawb Fawb (nquag los yog dielectric cov ntaub ntawv ua timreator)

TusNitro Pawgthiabfluorinated pab pawgQhia cov ntawv thov yuav hauv:

Cov Khoom Siv Hluav Taws Xob (Cov Khoom tawg, Propellants)

Cov kev tshwj xeeb polymers lossis cov khoom siv siab tshaj qhov twgKev-rho tawm haujlwmyog qhov tseem ceeb

Dielectric ntaub ntawvlossis nruab nrab rau semiconducting polymers

4. Hluav Taws Xob Nruab Nrab

Cov compound tej zaum yuav yog ib qhoNruab nrab nyob rau hauv synthesisntawm ntau dua complex Heterocycles.

NwsNtau qhov chaw ua haujlwmMuaj peev xwm rau kev ua haujlwm, xws li txo cov pawg Nitro, hloov cov kev cai, lossis qhib kev hloov pauv.

Cov txiaj ntsig

1. Kev ua haujlwm siab sib luag

Ua ke ntau cov chaw muaj kev tiv thaiv zoo: pawg uas muaj cov pab pawg uas muaj ntxhiab, carbonyl los ntawm trifluoroacetyl, thiab ib lub nplhaib bridsged.

Ua kom muaj ntau yamTshuaj Kho Mob, ntxiv cov nqi hluav taws xob hauv cov khoom siv tshuaj chemistricetch.

2. Muaj peev xwm bioavailability thiab ruaj khov

TusTrifluoroacetyl pawgtuaj yeem txhim khometabolic tsis kamthiablipophilicity, ntshaw nyob rau hauv cov chaw tsim hluav taws xob.

Tuaj yeem qhiakev ruaj khov nyob rau hauv oxidative thiab enzymatic tej yam.

3. Electron-tsis zoo moj khaum

Haum rauElectrophilic thiab nucleophilic hloov, tso cai koom nrog rau hauv cov tshuab molecular.

Pab tau rauCov Khoom Siv Hluav Taws Xoblossis redox-lub tshuab ua haujlwm.

4. Cov qauv nruj

TusBridged Methano Systemtxo cov kev sib xyaw ua ke, ib qho tshwj xeeb uas ua tau zooBinding tshwj xeebHauv kev tsim tshuaj thiabNEEG KHO TSHUAB STABTIONNyob rau hauv cov ntaub ntawv kev kawm.

Tag

2,3,4,5-tetrahydro-7,8-dinitro-3- (Methanoacetyl) -1,5-Benzauloo-1H-Benzauline-130615-59Kws Kho Mob R & D, Cov ntaub ntawv kawm txuj ci, thiabCov Khoom Siv Hluav Taws XobCov. Nws tshwj xeeb ua ke ntawm cov electron-rho tawm pawg, cov qauv nruj, thiab kev hloov kho cov haujlwm ua rau nws muaj txiaj ntsig zoo lossis scaffold rau kev tsimCov lwg me me moleculeslossisCov Khoom Siv Tshwj XeebCov. Kev kawm ntxiv lossis kev customization tuaj yeem qhib nws lub peev xwm tag nrho hauv kev thov kev tshawb fawb.