2-C-Methyl-D-Ribono-1,4-lactone 丨 CAS 492-30-8

1. Tseem ceeb intermediate nyob rau hauv nucleoside thiab antiviral synthesis

2-C-Methyl-D-Ribono-1,4-lactone yog lub tsev tseem ceeb ntawm cov hluav taws xob, ntau yam uas siv los ua cov tshuaj tua kab mob thiab anticancer.

Nws yog qhov tshwj xeeb tshaj yog nyob rau hauv synthesis ntawm:

Sofosbuvir (HCV Antiviral Tshuaj)

Ribavirin derivatives

Hloov nucleosides rau RNN-RESENT RNA polymerase inhibitors

Lub Methyl hloov ntawm 2-txoj hauj lwm ua rau nws muaj txiaj ntsig zoo rau synthesizing c-methylated qab zib maneties, ib qho kev ua kom muaj kev ruaj ntseg metabolic thiab potency ntawm ntau cov tshuaj tiv thaiv kab mob sib xyaw.

2. Pib cov khoom siv rau c-nucleoside synthesis

C-nucleosides sib txawv ntawm cov nucleosides tsis tu ncua nyob rau hauv tias cov piam thaj thiab lub hauv paus tau txuas los ntawm cov pa roj carbon-carbon (C-C) Nyiaj Txiag

Cov qauv no muaj ntau dua rau enzymatic cleanvage, ua rau lawv ntau ruaj nyob rau hauv kev siv hluav taws xob.

2-C-Methyl-D-Ribono-1,4-Lactone yog nquag ua hauj lwm los tsim cov piam thaj ua ke rau cov c-nucleosides vim nws cov teeb meem rigidity thiab yooj yim ntawm derivatization.

3. Chiral Nruab Nrab hauv cov xwm txheej hauv nruab nrog cev

Nws ntau txoj kev ua haujlwm thiab lactone ua haujlwm ua rau nws muaj kev pib ua haujlwm zoo tshaj plaws hauv cov khoom siv asymmetricesis.

Yuav siv tau los ua kom muaj ntau yam ntawm chairal lwg me me nrog kev ua haujlwm roj ntsha, xws li:

Hetercycles

Polyhydroxylated tebchaw

Qab Zib Analogs

4. Kev tshawb fawb hauv carbohydrate thiab nucleic acid tshuaj

Kev tshawb fawb ntau yam hauv kev kawm thiab kev tshawb fawb los kawm:

Kev sib luag

Nucleotide analog kev loj hlob

Cov txheej txheem ntawm kev nqis tes ua rau cov tshuaj antiviral

Kuj tseem muaj txiaj ntsig zoo hauv Enzymatic hloov kev tshawb fawb thiab cov tshuaj tiv thaiv glycosylation.

1. Kev xaiv siab thiab versatility versatility

Cov methyl pab pawg ntawm C-2 tsim cov regioselectivity thiab seroselectivity hauv cov kev tawm tsam hauv qab, uas yooj yim yooj yim ua ke ntawm cov khoom sib txuas ntawm cov khoom sib xyaw.

Nws lactone nplhaib tuaj yeem qhib tau yooj yim hauv qab mob me, muab cov kev nkag mus rau ntau cov saw rov qab-saw qab zib.

2. Txhim kho kev ua haujlwm me me hauv cov teb chaws kawg

Derivatives ntawm 2-C-Methyl Qab Zib Feem ntau saib cov roj ntsha ua kom zoo, suav nrog:

Txhim Kho Cov Tshuaj Pharmacokinetics

Ntau Tshaj Cell Permeability

Nce tsis kam rau kev ua phem

Cov cwj pwm tseem ceeb no yog qhov tseem ceeb rau cov tshuaj sib txawv tshuaj yuav ua rau cov kab mob kis zoo li RNA Polymerases.

3. Kev lag luam muaj thiab kho tau

Cov compound muaj nyob rau hauv kev coj dawb huv siab los ntawm ntau tus neeg muag khoom.

Nws yog cov cim, ua kom haum rau ob chav kuaj-nplai synthesis thiab kev siv yeeb tshuaj siv tshuaj.

4. Ib puag ncig tus phooj ywg

Ua ib qho qab zib derivative, nws yog feem ntau tsis yog-lom, biodegradable, thiab muab tau los ntawm cov khoom siv tau yooj yim dua.

Nws cov kev siv ua rau muaj ntau cov chevistry txoj hauv kev hauv cov tshuaj lag luam.