Methyl 6-Bromismotinate 丨 CAS CAS CASE 26218-78-0

1. Tshuaj Nruab Nrab

Methyl 6-Bromonicotinate yog lub tsev muaj txiaj ntsig zoo nyob hauv cov xwm txheej ntawm Heterocyclic siv tshuaj thiab cov khoom xyaw (API):

Qhov tseem ceeb Intermediate rau pyridine-muaj cov tshuaj scaffolds: cature site-txuas cov kev sib cav sib ceg xws li Suzuki, Sonogashira, lossis Buchwald-Hartwal Amination.

Siv nyob rau hauv Kinase inhibitors, antiviral, thiab anti-inflammatory cov neeg sib tw ua yeeb yam lub luag haujlwm hauv lub luag haujlwm hauv kev ua molecular thiab phiaj los khi.

Pawg methyl ester tuaj yeem yooj yim hydrolyzed rau cov kua qaub lossis hloov mus rau hauv cov chaw nyob, hydrazides, lossis lwm yam kev sib tw, nthuav tawm cov hluavtility versthanetic.

2. Agochnical synthesis

Ua haujlwm ua tus ua ntej ua ntej nyob rau hauv synthesis-raws li cov tshuaj ntsuab-raws li cov tshuaj tua kab, cov fungicides, thiab cog kev loj hlob regulators.

Halopyridines, suav nrog 6-bromonicotinate derivatives, tau paub tias yog cov coresative bioctive hauv cov qoob loo tiv thaiv vim lawv cov nroj tsuag cov hlab ntsha.

3. Hla-sib txuas kev ua haujlwm

Lub bromine ntawm txoj hauj lwm 6 tso cai rau cov molecule ua tus khub sib txuas ua ke hauv cov tshuaj tiv thaiv pd-catalalyzed rau:

Txuas Ayl, Alkyl, lossis Heterozeyl Pawg

Kev tsim kho ntau yam biaublel tshuab, uas muaj ntau hauv cov tshuaj thiab cov khoom siv science

4. Tshuaj Kho Mob Chemistry thiab ua kom ua tau zoo

Cov kev kawm txog kev ua ub no ntau ntxiv (SAR) kev tshawb fawb los txhim kho cov cim tshiab nrog kev siv tau ntau yam thiab xaiv tau.

Ua rau cov tshuaj tua neeg tshuaj tu tshuaj kom hloov pauv ntawm 6-txoj haujlwm ntawm pyridine, cuam tshuam rau receptor binding thiab metabolic ruaj khov.

5. Cov ntaub ntawv siv chemistry

Raws li lub koom haum Pyridine ua haujlwm, nws yuav raug siv rau hauv kev tsim ntawm:

Ligands rau kev sib koom tes

Lub tsev tsim hauv cov khoom siv hluav taws xob lossis cov ntaub ntawv kho qhov muag

Intermediates nyob rau hauv kev txhim kho ntawm cov polymers lossis dyes

1. Khoom cua verstility

Bromine Pab Pawg: Tso cai rau ntau yam hloov ntawm cov txheej txheem zoo tshaj plaws-txuas cov txheej txheem hla-txuas ntxiv (piv txwv li, Miyaura-inse, heck).

Ester ua haujlwm: Ua haujlwm derivatization rau hauv carboxylic acids, nyob rau hauv, hydrazing, thiab hydroxamic acids, txhawb molecular ntau haiv neeg.

2. Kev pab kho cov Molecule ua ke ua ke

Pab tau nyob rau hauv cov tswv yim synthesis nyob qhov twg heterocycles tau tsim nyob rau hauv ib qho kev sib txawv.

Muab kev nkag tau rau ntau lub Cyridine Cores, qhov tseem ceeb hauv cov tshuaj chemistry rau lub hom phiaj muaj affinity thiab bioavailability.

3. Zoo ruaj khov thiab kov

Ruaj khov nyob rau hauv ib txwm cia thiab kuaj mob.

Feem ntau muaj raws li cov hmoov ua khov kho lossis ua kom yooj yim kom hnyav, khaws cia, thiab kov hauv ob qho me me thiab hluav taws xob.

4. Kev Lag Luam Kev Lag Luam

Dav muaj cov neeg siv tshuaj rau kev tshawb fawb-qib thiab cov khoom siv ntau, txhawb nws siv hauv kev tshawb fawb thaum ntxov thiab teev-nce ntau lawm.

5. Siv tau rau Green Chemistry

Tau tshaj Microwave-pab cuam Erthesis, cov kuab tshuaj tiv thaiv, thiab lwm cov kev sib tw ua haujlwm hauv zej zog.