3-amino-4-pyrazolecarbon teitrile 丨 CAS 16617-46-2

1. Tshuaj Nruab Nrab Nruab Nrab

3-amino-4-pyrazolecarbonitrile yog dav siv raws li qhov tseem ceeb hauv synthesis ntawm ntau cov neeg sib tw ntawm cov yeeb ncuab, suav nrog:

Anticancer Cov Neeg Sawv Cev
Nws pyrazole nplhaib tau pom nyob rau hauv ntau kineral inhibitors thiab antitumor tebchaw. Lub nitrile thiab pawg amino pab ua haujlwm rau kev ua haujlwm ntxiv rau ntxiv derivatization, xws li kev tsim cov lus teb, imines, lossis heteroaromatic txuas ntxiv.

Anti-inflammatory thiab cov tshuaj analgesic
Pyrazole-raws li scaffolds feem ntau siv hauv kev txhim kho ntawm Cox-2 inhibitors thiab lwm yam mob-rov ua neeg sawv cev.

Antiviral thiab Antimicrobial tus neeg sawv cev
Kev hloov kho ntawm amino lossis nitrile txoj haujlwm tuaj yeem tawm cov khoom sib txuas nrog cov kev ua haujlwm dav dav, suav nrog cov kev ua haujlwm muaj peev xwm tiv thaiv cov kab mob, fungi, lossis viruses.

2. Agochnical synthesis

Ua raws li lub tsev thaiv rau cov tshuaj tua kab, cov fungicides, thiab tshuaj tua kab.

Cov tub ntxhais pyrazole cov tub ntxhais ua rau muaj kev xaiv thiab potency ntawm cov khoom xyaw nquag siv hauv kev tiv thaiv qoob loo.

Pab txhawb nqa cov lus qhia ntawm cov analogs nrog cov kev ua si vim nws cov kev cuam tshuam thiab sib xyaw nrog ntau yam kev hloov pauv.

3. Heterocyclic thiab zoo tshuaj lom neeg hluavtaws

Ua hauj lwm ua tus thawj coj ua ntej rau cov synthesis ntawm ntau cov pyazole derivatives, thiab pyrazoloprodiazines, uas yog qhov tseem ceeb hauv tshuaj thiab khoom siv chemsis.

Pab tau nyob rau hauv ntau-kauj ruam organic synthesis vim nws txoj kev bifunctional (amino thiab nitrile pab neeg), pub muaj kev sib txawv xws li xws li:

Kev kawm txog tsheb

Kev tso luag

Lwg

Nucleophilic hloov

4. Tshawb nrhiav thiab kev txhim kho

Feem ntau siv hauv kev tshawb fawb thiab kev tshawb fawb rau cov qauv-kev sib raug zoo (SAR) kev tshawb fawb muaj feem xyuam nrog pyazole moj khaum.

Pab nyob rau hauv kev tshawb nrhiav ntawm cov tshuaj tshiab-zoo li lwg me me vim nws cov qauv zoo nta.

1. Ob pab pawg ua haujlwm rau ntau yam

Cov pab pawg -Nh₂ thiab -cn txhua pab tso cai rau ntau cov kev hloov tshuaj lom.

Txhawb nqa derivatization rau kev ua ntau yam hloov pauv ntau yam heterocycles, ua rau nws muaj hluavtaws hluavtaws ntau yam.

2. Cov siab ua kom zoo thiab sib xyaw

Reacts zoo nyob rau hauv cov mob me me nrog electrophiles thiab nucleophiles.

Tau tshaj microwave-pab, ntsuab, lossis khoom-theem synthesis cov txheej txheem, uas yog nyiam nyob rau hauv niaj hnub tshuaj pom kev tshuaj.

3. Kws muag tshuaj-kev nplua nuj scaffold

Lub nplhaib pyrazole yog tus qauv tsim nyog hauv kev ua tshuaj chemistry vim nws nyiam:

Hydrogen Tsev Muaj Peev Xwm

Qhov ua kom hluav taws xob

Khi rau biological phiaj

Qhov no ua rau 3-amino-4-pyrazolecarbonitrile ib qho kev pib ua zoo tagnrho rau kev tsim cov lwg me me nrog kev ua haujlwm siab.

4. Kev lag luam muaj thiab tus nqi-txiaj ntsig

Npaj tau yooj yim muaj los ntawm cov chaw muag khoom ntawm cov tshuaj lom neeg, ua rau nws haum rau ob qho kev sim R & D thiab tsav thiab sim ntau lawm.

Raug nqi-ua haujlwm nruab nrab rau synthesizing high-tus nqi kawg cov khoom lag luam xaus.

5. Kev txhawb nqa cov tshiab molecule kev loj hlob

Txhawb nqa lub tsev qiv ntawv tiam nyob rau hauv Combinatorial Chemical Premisent vim nws cov qauv qauv.

Txhawb cov kev tshawb nrhiav ntawm cov qauv tshiab hauv cov kev siv tshuaj.