Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov kws tshaj lij thiab cov neeg muag khoom ntawm baricitinib丨cas 1187594-09-7 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo tshuaj cov khoom ntawm kev sis tw nqi los ntawm peb lub hoobkas. Yog tias koj muaj lus nug txog kev pabcuam kev cai, thov koj xa email rau peb.
Specifications
| Qhov tshwm sim | Dawb rau tawm -dawb crystalline hmoov |
| Assay | 98%-102% |
| Kev txheeb xyuas | Yuav tsum ua raws li kev siv |
| Melting point | 211-216 degree |
| Dej | 0.5% max |
| Residue ntawm ignition | 0.2% max |
| Cov hlau hnyav | 10 ppm max |
| Ib leeg impurity | 0.1% max |
| Tag nrho impurities | 1% max |
| Methanol | 0.3% max |
| Dichloromethane | 0.06% max |
| Ethanol | 0.5% max |
| Tetrahydrofuran | 0.072% max |
| Cov tshuaj acetonitrile | 0.041% max |
| N,N{0}}Dimethylformamide | 0.088% max |
Daim ntawv thov
Baricitinib feem ntau yog siv los kho cov kab mob autoimmune, tshwj xeeb tshaj yog nyob rau nruab nrab mus rau mob rheumatoid mob caj dab loj, qhov uas nws pab txo qis kev sib koom tes, mob, thiab kev puas tsuaj ntawm cov qauv. Nws tseem nyob rau hauv kev tshawb nrhiav thiab siv rau lwm yam mob thiab tiv thaiv kab mob - kho mob, nrog rau cov kab mob atopic dermatitis thiab qee yam kab mob cytokine cua daj cua dub. Tsis tas li ntawd, baricitinib tau kawm raws li kev kho mob ntxiv rau kev kis kab mob, qhov kev hloov pauv ntawm lub cev tsis muaj zog tuaj yeem txhim kho cov txiaj ntsig ntawm tus neeg mob. Hauv kev tshawb fawb tshuaj, nws ua haujlwm ua qauv sib xyaw rau JAK inhibition kev tshawb fawb, pab cov kws tshawb fawb nkag siab txog kev xaiv kinase, qhia txoj hauv kev, thiab cov tshuaj metabolism. Nws zoo -cov tshuaj pharmacokinetics thiab cov txheej txheem ntawm kev ua haujlwm ua rau nws muaj txiaj ntsig zoo rau kev tsim kho tshiab tsom rau cov kab mob autoimmune thiab inflammatory kab mob.
Cov txiaj ntsig
Ib qho txiaj ntsig tseem ceeb ntawm baricitinib yog nws lub peev xwm los xaiv inhibit JAK1 thiab JAK2, uas tso cai rau kev hloov pauv ntawm cytokine signaling thaum txo qis kev tiv thaiv kab mob. Qhov kev xaiv no ua rau nws muaj txiaj ntsig zoo hauv kev txo qhov mob thiab txhim kho cov txiaj ntsig kev kho mob hauv cov neeg mob rheumatoid mob caj dab thiab lwm yam kev tiv thaiv kab mob- kho mob. Nws yog qhov ncauj bioavailable, muab kev yooj yim ntawm kev txhaj tshuaj biologics thiab txhim kho tus neeg mob ua raws li kev kho mob. Baricitinib muaj qhov ua tau zoo ntawm cov tshuaj pharmacokinetic, tso cai rau kev siv tshuaj yoog raws thiab kev sib xyaw ua ke muaj peev xwm. Tsis tas li ntawd, nws qhov me me -molecule xwm pab txhawb kev tsim tshuaj lom neeg, kev ruaj ntseg, thiab kev ua kom muaj zog piv nrog cov tshuaj lom neeg loj. Nws cov txiaj ntsig kho tau zoo hauv kev tswj hwm lub cev tiv thaiv kab mob ntau dhau qhia txog nws qhov tseem ceeb hauv kev kho mob hauv ob qho tib si mob autoimmune thiab mob hnyav.
Xaus
Baricitinib yog ib qho muaj zog JAK1 / JAK2 inhibitor nrog kev siv dav hauv kev kho kab mob autoimmune thiab kev tswj tus mob inflammatory. Nws cov txheej txheem xaiv, qhov ncauj bioavailability, thiab zoo-tsim kho tshuaj profile ua rau nws muaj txiaj ntsig zoo rau tus neeg saib xyuas thiab tshawb fawb cov cuab yeej hauv kev tiv thaiv kab mob thiab kev tsim tshuaj. Raws li cov phiaj xwm kinase inhibitors txuas ntxiv ua cov tshuaj niaj hnub, baricitinib tseem yog ib qho tshuaj tseem ceeb hauv kev kho mob rheumatoid mob caj dab thiab lwm yam kev tiv thaiv kab mob - kho mob.
Cim npe nrov: Tuam Tshoj baricitinib cas 1187594-09-7 manufacturers, lwm tus neeg, Hoobkas
