Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov kws tshaj lij thiab cov neeg muag khoom ntawm rgh188 hydrochloride丨cas 1083076-69-0 hauv Suav teb. Txais tos rau kev lag luam wholesale kev cai ua cov khoom lag luam ntawm tus nqi sib tw los ntawm peb lub hoobkas. Rau cov khoom pheej yig dua, tiv tauj peb tam sim no.
↵
Specifications
| Qhov tshwm sim | Tawm -dawb mus rau hmoov dawb |
| Kev txheeb xyuas RT (los ntawm HPLC) | Ua raws li tus qauv siv |
| Purity | 99% min |
| P-XRD | Ua raws li tus qauv siv |
| Qhuav weightlessness | 0.5% max |
| Hnyav hlau | 20 ppm max |
| Qhov siab tshaj plaws ib qho impurity | 0.15% max |
| Tag nrho impurity | 1% max |
| cis-isomer | 0.15% max |
| Cov kuab tshuaj seem - Methanol | 3000 ppm max |
| Cov kuab tshuaj seem - Ethyl Acetate | 5000 ppm max |
| Cov kuab tshuaj residual - Acetonitrile | 410 ppm max |
| Assay (los ntawm HPLC) | 98%–102% |
Daim ntawv thov
RGH188 hydrochloride (CAS 1083076-69-0) yog hydrochloride ntsev ntawmcariprazine, ib qho tshiab atypical antipsychotic compound siv dav hauv kev tshawb fawb neuroscience thiab kev tsim tshuaj. Nws yog feem ntau siv raws li kev tshawb fawb-qib cov ntaub ntawv siv los yog cov tshuaj siv tshuaj nruab nrab los kawm txog dopaminergic thiab serotonergic signaling pathways, tshwj xeeb tshaj yog koom nrog dopamine D₂ thiab D₃ receptors thiab 5-HT₁A receptors. Nyob rau hauv preclinical pharmacological kev tshawb fawb, nws yog siv los ua cim receptor binding profiles, signaling mechanisms, thiab koob tshuaj- teb kev sib raug zoo nyob rau hauv vitro thiab nyob rau hauv vivo, ua ib tug cuab yeej los soj ntsuam antipsychotic kev ua tau zoo, kev txawj ntse los, thiab kev coj cwj pwm tshwm sim nyob rau hauv cov tsiaj qauv. Tsis tas li ntawd, cariprazine hydrochloride yog siv rau hauv tshuaj chemistry los txhawb kev sib txuas thiab kev ua kom zoo ntawm cov neeg ua haujlwm psychotropic tom ntej, muab cov qauv ntsuas rau kev sib piv cov tshuaj tshiab uas tsom rau txoj hauv kev zoo sib xws CNS. Vim tias nws cov kev sib cuam tshuam receptor zoo, nws kuj yog ib qho qauv sib xyaw hauv kev soj ntsuam tsim los tshuaj xyuas rau dopamine D₃ / D₂ modulators thiab serotonergic modulators rau kev tshawb fawb txog kev puas siab puas ntsws.
Cov txiaj ntsig
Cov txiaj ntsig ntawm RGH188 hydrochloride qia los ntawm nwstxawv pharmacological profile thiab kev siv hluav taws xob raws li cov cuab yeej tshawb fawbhauv CNS tshuaj nrhiav pom. Raws li kev xaiv heevIb nrab agonist ntawm dopamine D₃ thiab D₂ receptors, nrog tshwj xeeb muaj zog affinity rau D₃ subtype, nws enables meej modulation ntawm dopaminergic neurotransmission nyob rau hauv kev sim tshuab, pab soj ntsuam xyuas dissect complex neuropsychiatric mechanisms. Nws muaj kev sib cuam tshuam nrog cov5-HT₁A receptortxuas ntxiv txhawb kev tshawb fawb txog kev xav, kev paub, thiab kev ntxhov siab ntsig txog txoj hauv kev. Vim tias nws ua raws li qhov tseem ceeb ntawm atypical antipsychotic kev ua si yam tsis tas yuav tsum tau siv tshuaj kho mob, cariprazine hydrochloride tso cai rau kev soj ntsuam ntawm tus cwj pwm thiab biochemical tshwm sim hauv cov qauv ntawm tus mob schizophrenia, kev puas siab puas ntsws bipolar, thiab lwm yam kab mob CNS. Chemically, cov ntsev hydrochloride yog qhov ruaj khov thiab yooj yim dua los tuav ntau dua li lub hauv paus dawb, txhim kho kev tsim tawm hauv kev tsim thiab siv tshuaj thaum lub sijhawm tshawb fawb. Nws cov yam ntxwv muaj txiaj ntsig zoo sib xws thiab cov ntaub ntawv receptor selectivity ua rau nws muaj kev ntseeg siab rau kev sib piv cov tshuaj thiab kev ua kom zoo tshaj plaws hauv CNS kev kho mob.
Xaus
RGH188 hydrochloride yog ib qho kev tshawb fawb-tsim daim ntawv ntawm cariprazine, muaj nuj nqis rau nwssiab selectivity raws li ib tug dopamine D₃ / D₂ ib feem agonist thiab kev siv hluav taws xob hauv neuroscience thiab kev tshawb fawb tshuaj puas hlwb. Nws lub luag hauj lwm raws li kev siv tshuaj sib txuas thiab nruab nrab hauv kev tshawb fawb preclinical txhawb kev tshawb fawb ntawm dopaminergic thiab serotonergic mechanisms cuam tshuam nrog kev ua haujlwm ntawm kev puas siab puas ntsws, kev paub txog kev ua haujlwm, thiab kev tswj lub siab. Qhov sib xyaw ua ke ruaj khov raws li cov ntsev hydrochloride thiab nws cov ntaub ntawv zoo receptor profile ua rau nws yog ib qho cuab yeej tseem ceeb hauv CNS tshuaj nrhiav pom, ua kom muaj kev tshawb fawb zoo ib yam, rov tsim dua tshiab uas qhia txog kev tsim cov tshuaj kho mob siab heev.
Cim npe nrov: rgh188 hydrochloride 丨cas 1083076-69-0, Tuam Tshoj rgh188 hydrochloride丨cas 1083076-69-0 manufacturers, lwm tus neeg, Hoobkas
