Cov lus qhia
| Zog: | Dawb lossis tawm dawb hmoov |
| Assisy (hplc): | 99–101% |
| Daim qhia npe: | Tsis kam |
| Dej: | 4% Max |
| Lwm yam impuration - ib tug neeg impurity: | 0.5% max |
| Lwm yam los cuam tshuam - tag nrho cov impurities: | 1% Max |
Cov Ntaub Ntawv Thauj
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Chaw ua uas tsis tau haus |
Kev qhia tshwj xeeb |
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UN NUM |
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Hom |
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Cov Pab Pawg |
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Hs code |
2933599053999 |
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Ruaj khov & rov ua |
Cov khoom lag luam ruaj khov nyob rau hauv cov qauv ambient ambient. |
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Chaw ntim khoom |
Nruj nreem kaw. Khaws rau hauv qhov chaw kaw, qhuav, qhov chaw cua |
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Mob kom tsis txhob |
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Lub thawv |
Cov ntaub ntawv raug
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Chaw ua uas tsis tau haus |
Kev qhia tshwj xeeb |
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Lub peev xwm |
100kg / hli |
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Hov ntau |
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Lub teb chaws tseem ceeb |
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Peev Xwm / Batch |
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Paub lawm |
Ntau lawm txij xyoo 2009 |
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Ntxiv rau |
Cov Ntawv Thov
1.1 Kev Kho Mob Hom 2 Ntshav Qab Zib Mellitus
Sitagliptin hcl monohydrate yog thawj-hauv-chav kawm DPP-4 inhibitor siv rau:
Txhim Kho Glycemic Kev Tswj Hauv Cov Laus uas muaj Hom 2 Ntshav Qab Zib Mellitus (T2Dm)
Yuav tsum tau sau tseg ib leeg lossis hauv kev sib xyaw nrog lwm cov tshuaj antidboticetic zoo li:
Tus metformin
Sulfonyhluras
Thiazolidinesion (piv txwv li, Pioglitazone)
Tshuaj ivxulis
Nws tsis yog siv rau hom ntshav qab zib hom 1 lossis ntshav qab zib ketoacidosis.
1.2 Cov Tshuaj Txhuam Ntawm Qhov Ncauj Tus Kheej
Tsis zoo li insulin lossis txhaj tshuaj nkoog-1 analogs, sitagliptin yog qhov ncauj thiab haum rau:
Cov khoom siv tawm mus ntev
Cov neeg mob uas nyiam cov ntsiav tshuaj ntawm kev txhaj tshuaj
1.3 Tsau-DAs Ua ke cov khoom
Sitagliptin feem ntau tsim nyob rau hauv kev siv tshuaj tiv thaiv tas li xws li:
Sitagliptin + Metformin (Hom Lub Npe: Janumet ®)
Cov kev sib xyaw ua ke no yooj yim kho thiab txhim kho kev ua raws kev ua raws.
1.4 Kev tshawb nrhiav thiab kev siv sib txuas
Kev Tshawb Fawb Txog Kev Tshawb Fawb Ua Ntej Sitagliptin rau cov txiaj ntsig muaj txiaj ntsig hauv:
Kev Tiv Thaiv Kev Tiv Thaiv Cardiovascular
Kev tswj qhov hnyav
-cell khaws cia
Cov kev hloov pauv hloov hauv cov metabolic syndrome
Cov txiaj ntsig
2.1 dpp-4 inhibition mechanism
Sitagliptin ua haujlwm los ntawm Inhibiting Enzyme Dipeptidyl Peptidas-4 (DPP-4), uas:
Nce ntau ntau ntawm cov tshuaj hormones incretin (GLP-1 thiab GIP)
Txhim kho cov txiaj ntsig zoo roj qab zib
Suppresses glucag tso
Pab txo qis dua thiab yoo ntshav ntshav qab zib
2.2 qhov hnyav-nruab nrab thiab qis dua kev pheej hmoocemia
Tsis zoo li sulfonyhluras lossis insulin:
Sitagliptin yog qhov hnyav nruab nrab
Muaj kev pheej hmoo tsawg ntawm hypoglycemia, tshwj xeeb tshaj yog thaum tsis siv nrog sulfonyhluras lossis insulin
2.3 ib zaug ib hnub noj
Nws muaj ib nrab-ib nrab-lub neej (~ 12.4 teev), cia ib zaug noj tshuaj, uas:
Txhim Kho Tus Neeg Yuav Yooj Yim
Txhim kho kev ua raws li kev kho mob
2.4 Lub raum kev nyab xeeb thiab kev hloov kho tau hloov kho
Thaum sitagliptin yog feem ntau renally excreted, nws yog feem ntau zoo rau siab rau hauv cov neeg mob uas muaj mob raum tsis ncaj.
2.5 Kev zam tau zoo nrog cov kev mob me
Cov kev phiv zoo ib yam muaj mob me thiab muaj xws li:
Nasophylitis
Mob taub hau
Kev mob siab sab saud
Tsis tshua muaj tshwm sim tab sis cov kev tsis txaus siab loj (piv txwv li, pancriceititis, kev xav tsis thoob) muaj kev soj ntsuam kom zoo nrog kev soj ntsuam kom zoo.
Tag
Sitagliptin hcL Monohydrate (CASHDRATE (CASE 862156-92-1) yog lub pob zeb ntawm hom 2 qhov kev tswj hwm niaj hnub no, tus neeg mob kev nyab xeeb ntawm kev nyab xeeb. Los ntawm kev txhim kho lub cev ntawm lub ntuj incretin system los ntawm DPP-4 inhibition, sitagliptin pab tswj cov theem zoo li cov dej qab zib yam tsis muaj qhov tseem ceeb ntxiv. Nws cov kev sib xyaw ua ke rau hauv kev kho mob thiab cov tshuaj tiv thaiv tas nrho ntxiv ntxiv dag zog rau nws lub luag haujlwm ntawm kev saib xyuas ntshav qab zib. Nrog kev tshawb fawb txog kev loj hlob mus rau nws cov txiaj ntsig txuas ntxiv dhau kev tswj kom muaj kev sib tw tseem ceeb hauv kev ua kom lub nra hauv ntiaj teb ntawm hom 2 ntshav qab zib.
Cim npe nrov: Txawm li cas los xij 86215621562156-92-1, Tuam Tshoj sitagliptin hc yog 862156-92-1 cov chaw tsim khoom, cov chaw tsim khoom, chaw tsim khoom
