Cov lus qhia
| Zog: | Dawb rau off-dawb hmoov |
| Solubility Clarity: | 0.2 m kev daws teeb meem hauv acetonitrile yog pub dawb los ntawm tsis muaj kev cuam tshuam |
| Tus kheej (los ntawm HNMR): | Txhawm rau ua raws cov qauv |
| Purity (HPLC): | 99.0% min |
| Ib qho tseem ceeb impuration: | 0.3% max |
| Tsis yog-tseem ceeb ib qho impurity: | 0.5% max |
| Tsis paub ib leeg impurity: | 0.3% max |
| 31P NMR Purity: | 98.0% min |
| P (iii) impurities (100-170 ppm): | 0.5% max |
| Residual Hnyav: | 3.0% Max |
| Nws noo: | 0.5% max |
Cov Ntawv Thov
1. Khoom cua RNA oligonucleAruction ntau lawm
Siv rau hauv cov khoom-theem oligonucleide synthesis (SPOS) los tsim cov tshuaj hloov kho RNA strands.
Qhov tseem ceeb rau kev npaj RNA uas muaj 2'---me-methyl kev hloov kho, uas yog pom ib txwm nyob rau hauv RRNA, TRNA, thiab kev tswj hwm rnas.
2. RNA HHNAPEUTICS KEV LOJ
Incorporated rau hauv Sirna, MRNA, Antisension Oligonucleides (ASS), thiab RNA ApTamers.
2'-o-methyl hloov kho:
Txhim khu kev tiv thaiv mus rau NucLase kev ua tsis zoo
Txo kom tsis txhob muaj kev tiv thaiv kev tiv thaiv
Txhim kho RNA ruaj khov thiab pharcermonininetics hauv vivo
3. EpitransCROTOMICOMOMICS THIAB RNNY Kev Tshawb Xyuas Kev Hloov Kho
Ua rau txoj kev kawm ntawm lub luag haujlwm ntawm ntuj 2'-o-Methylguamosine hauv RNA fiting, txhais lus, thiab paub los ntawm cov protein.
Pab tau rau Profiling thiab Mapping RNA hloov kho hauv cov piv txwv txheeb xyuas.
4. Biochemical thiab cov qauv kev kawm
Pab cov qauv tsim qauv-ua haujlwm uas muaj kev cuam tshuam nrog RNA hloov.
Tso cai rau cov kws tshawb nrhiav kev kawm RNNA-protein kev sib cuam tshuam, thiab RNA folding dynamics nrog kev ruaj khov.
Cov txiaj ntsig
✔ Tshaj Siab RNA ruaj khov
2'-o-Methyl kev hloov kho muab kev tiv thaiv RNASES, nce RNA ib nrab lub neej nyob hauv ib puag ncig.
Og Kev rho tawm impunogenicity
Hloov Rnas tsis tshua muaj feem yuav ua rau cov lus teb tsis muaj zog, uas yog qhov tseem ceeb rau kev kho siv hauv tib neeg hauv tib neeg.
✔ Zoo thiab muaj txiaj ntsig zoo sib xws
DMT, N-IBU, thiab Cedpa tiv thaiv pab pawg ua kom muaj txiaj ntsig zoo, ib qib-synthesis nrog kev ua tau zoo tshaj plaws.
✔ Kev Ntseeg Hluav Taws Xob
Mimics ib txwm tshwm sim RNA kev hloov kho, tso cai tsim kev tsim tawm ntawm biologically thiab cov qauv muaj hluavtaws muaj tseeb.
Tag
5-O-DMT-2-O-Me-RG (NBU) -3-Cedpa -3-CedpaCub Nws cov ntawv thov Spans los ntawm kev txhim kho RNAtectic RNAtection (piv txwv, Sirna, mRAA cov tshuaj tiv thaiv) rau kev tshawb fawb biochemical thiab epigenetic. Los ntawm kev txhim kho RNA kev ruaj khov, txo cov immunogenicity, thiab ua kom meej meej meej txog kev hloov kho ntawm biology thiab kws tshuaj tsim kev txhim kho.
Cim npe nrov: 5-O-DMT-2-O-Me-RG (NBU) -3-Cedpa -3-O-DMT-2-O-DGT-2-O-DGT-2-丨 CAS 150-67-9 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj
