Cov lus qhia
| Zog: | Dawb rau off-dawb hmoov |
| Solubility scarity (hauv acetoniturile thiab 20% dmf): | 0.2 m kev daws teeb meem yog pub dawb los ntawm tsis muaj kev cuam tshuam |
| Solubility Clarity (hauv Dichhloromethane: Acetonitrile 50:50): | 0.2 m kev daws teeb meem yog pub dawb los ntawm tsis muaj kev cuam tshuam |
| Tus kheej (los ntawm HNMR): | Txhawm rau ua raws cov qauv |
| Purity (HPLC): | 99.0% min |
| Ib qho tseem ceeb impuration: | 0.3% max |
| Tsis yog-tseem ceeb ib qho impurity: | 0.5% max |
| Tsis paub ib leeg impurity: | 0.3% max |
| 31P NMR Purity: | 98.0% min |
| POI Impurities (100-170 PPM): | 0.5% max |
| Residual Hnyav: | 3.0% Max |
| Nws noo: | 0.5% max |
Cov Ntawv Thov
1. Khoom cua RNA oligonucleAruction ntau lawm
Siv rau hauv cov khoom-theem oligonucleide synthesis rau generating rnas uas muaj 2'-o-methyluridine.
Feem ntau thov hauv:
sirna ruwser
Cov Tshuaj Tiv Thaiv Mirna
RNA Aptamers
Antisense Oligonucleides (Asos)
2. RNACHERSUTICS
Pab txhawb kev tsim cov tshuaj txawb ruaj khov nrog cov khoom siv roj ntsha txhim kho.
2'-o-methyl hloov kho pab:
Nce kev tiv taus ribonuckases
Txhim kho cov kab mob tshwj xeeb
Txo cov teebmeem-hom phiaj
Txo cov immunogenicity hauv vivo
3. EpitransCriptic thiab molecular biology kev tshawb fawb
Siv nyob rau hauv Hloov RNA synthesis los tshawb nrhiav lub luag hauj lwm roj ntsha ntawm 2'-o-methylation, tshwj xeeb hauv RRNA, Trna, thiab SNRA, thiab SNRA, thiab SNRA, thiab SNRA, thiab SNRNA.
Pab qauv cov qauv siv RNN rau kev tsim qauv qauv.
4. Kev kuaj mob thiab cov cuab yeej soj ntsuam
Kev koom ua ke rau hauv RNA Probes thiab Biosensors los txhim kho cov phiaj xwm kev lees paub thiab kev ruaj ntseg hauv kev siv roj ntsha.
Cov txiaj ntsig
1. Txhim Kho RNA ruaj khov
Qhov 2'-o-methyl pab pawg tau nce ntxiv mus rau enzymatic degradation los ntawm rnases.
2. Txo kev tiv thaiv kev tiv thaiv kev tiv thaiv
Hloov cov nucleosides hloov zoo li 2'-o-kuv-ru pab hluavtaws RNate inn inn entin entate extection, tseem ceeb rau kev kho mob.
3. Txhim Kho Hybridization Tshwj Xeeb
2'-o-methyl hloov kho txhim kho duplex muaj peev xwm thiab txhim kho hom kev ntxub ntxaug hauv kev ua kom muaj kev ntxub ntxaug thiab sirna daim ntawv thov.
4. Txhim Kho Khoom Zoo
DMT thiab Cedpa tiv thaiv pab pawg kom ntseeg siab cov txuas kev ua tau zoo thiab kev ua kom siab frantance RNA synthesis.
Tag
5-O-DMT-2-O-Me-Me-Nedpa (CAS-10764-79-9) yog cov tshuaj phosphoramidate no tsim los ua kom haum rau cov cuab yeej RNAthetic RNA. Nws yog qhov tseem ceeb nyob rau hauv kev tsim cov ruaj khov, tsawg-immunogenic, high-ua tau zoo RNA oligonucleotides siv, molecular cov cuab yeej. Nrog siab ruaj khov thiab synthesis efficiency, nws plays lub luag hauj lwm tseem ceeb hauv kev nce qib RNA thiab EpitransCTomics.
Cim npe nrov: 5-O-DMT-2-O-Me-NEDPA 丨 CAS 110764-79-9, Tuam Tshoj 5-O-D-3-CEDPA 丨 CAS 110764-79-9 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas
