![5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 丨 CAS 231278-84-5](/uploads/42644/5-4-3-chloro-4-3-fluorobenzyl-oxy-phenyl48590.png)
Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov tuam txhab tshaj lij thiab cov neeg muag khoom ntawm 5-[4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde丨cas 231278-84-5 hauv Suav teb. Txais tos rau kev lag luam wholesale kev cai ua cov khoom lag luam ntawm tus nqi sib tw los ntawm peb lub hoobkas. Rau cov khoom pheej yig dua, tiv tauj peb tam sim no.
Specifications
| Qhov tshwm sim | Yellow rau greenish daj xim hmoov |
| Assay | 98.0% ~ 102.0% (Xau ntawm lub hauv paus qhuav) |
| Solubility | Me ntsis soluble hauv dimethylformamide |
| Kev txheeb xyuas | HPLC: Lub sijhawm khaws cia ntawm lub ncov loj hauv chromatogram ntawm cov qauv kev daws teeb meem yuav tsum sib haum rau cov qauv kev daws teeb meem raws li tau txais hauv cov khoom muaj feem xyuam |
| Poob rau ziab | 5.0% max |
| Residue ntawm ignition | 0.5% max |
| Lwm Yam Khoom - Impurity A | 0.15% max |
| Yam khoom muaj nqis - Impurity B | 0.10% max |
| Yam Khoom - Impurity C | 0.10% max |
| Lwm Yam Khoom - Impurity D | 0.10% max |
| Yam Khoom - Impurity E | 0.10% max |
| Lwm Yam Khoom - Impurity F | 0.10% max |
| Yam Khoom - Impurity G | 0.10% max |
| Lwm Yam Khoom - Impurity H | 0.05% max |
| Lwm tus neeg impurity | 0.5% max |
| Tag nrho impurities | 1.0% max |
Daim ntawv thov
5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde yog ib qho kev ua haujlwm me me uas feem ntau siv hauv kev tshawb fawb tshuaj thiab tshuaj chemistry. Nws ua haujlwm raws li qhov tseem ceeb nruab nrab hauv kev txhim kho kinase inhibitors thiab lwm cov tshuaj tiv thaiv kab mob, qhov twg quinazoline core muab lub scaffold rau receptor thiab enzyme kev cuam tshuam. Cov molecule yog siv nyob rau hauv cov qauv-kev sib raug zoo kev sib raug zoo (SAR) kev tshawb fawb los optimize potency, selectivity, thiab pharmacokinetic zog ntawm cov neeg sib tw tshuaj. Nws cov furaldehyde thiab hloov phenyl pawg tso cai rau kev hloov kho tshuaj ntxiv, ua rau kev tshawb nrhiav ntau yam derivatives hauv kev tshawb nrhiav tshuaj. Tsis tas li ntawd, cov tshuaj no yog siv rau hauv kev tshawb fawb preclinical rau kev soj ntsuam enzyme inhibition, receptor binding kev tshawb fawb, thiab kev tshawb nrhiav tshuab ntawm cov teeb liab transduction txoj kev cuam tshuam rau kev mob qog noj ntshav thiab lwm yam kab mob proliferative.
Cov txiaj ntsig
Cov txiaj ntsig ntawm qhov sib xyaw no tshwm sim los ntawm nws cov qauv siv ntau yam, sib xyaw ua ke, thiab tsim nyog rau precision tshuaj chemistry. Cov tub ntxhais quinazoline muab cov receptor muaj zog- khi lub peev xwm, thaum lub chloro, fluoro, thiab furan aldehyde hloov pauv tso cai rau kev hloov kho tshuaj los txhim kho bioactivity thiab xaiv. Nws zoo-txhais qauv molecular txhawb kev tsim cov khoom sib txuas, siab-kev cais tawm kom huv, thiab txhim khu kev koom ua ke rau hauv ntau-txoj kev hluavtaws. Cov molecule cov pab pawg ua haujlwm tau ua rau muaj kev sib txawv, suav nrog kev sib xyaw ua ke, hloov pauv nucleophilic, thiab kev sib txuas, ua kom yooj yim rau kev tsim analog sai rau SAR optimization. Nws compatibility nrog cov txheej txheem organic solvents thiab kuaj tej yam kev mob ua kom yooj yim ntawm tuav nyob rau hauv kev tshawb fawb thiab kev loj hlob chaw.
Xaus
5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde yog ntau yam thiab muaj txiaj ntsig nruab nrab hauv kev tshawb fawb tshuaj thiab tshuaj chemistry. Nws cov qauv siv ntau yam thiab cov tshuaj muaj zog ua kom muaj kev tsim thiab kev sib txuas ntawm cov neeg sib tw tshuaj, tshwj xeeb tshaj yog kinase inhibitors thiab receptor-modulating compounds. Los ntawm kev txhawb nqa muaj txiaj ntsig zoo, kev tshawb nrhiav SAR, thiab kev tshawb fawb ua ntej, cov khoom siv no tseem yog ib qho tseem ceeb hauv kev tshawb nrhiav tshuaj niaj hnub thiab kev siv tshuaj lom neeg lom neeg.
Cim npe nrov: 5-[4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 丨cas 231278-84-5, Suav teb 5-[4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 丨cas 231278-84-5 manufacturers, lwm tus neeg, Hoobkas
