Cov lus qhia
| Zog: | Cov hmoov dawb |
| HPLC assay: | 98.0–102.0% |
| Daim qhia npe: | IR / HPLC |
| Dej: | 0.5% max |
| Residue ntawm ignition: | 0.1% Max |
| Ethanhol: | 0.5% max |
| Dichhloromethane: | 0.06% max |
| Ib qho impurity: | 0.1% Max |
| Tag nrho cov impurity: | 0.5% max |
| Solubility: | Soluble me ntsis hauv Tetranlefofuran, sparingly soluble hauv n, n-Downethylformamide, heev me ntsis soluble hauv acetoniturile, thiab suab insoluble hauv dej. |
| Microbial txwv - Tamc: | 1000 cfu / g max |
| Microbial txwv - TMCC: | 100 cfu / g max |
| E. Coli: | Tsis tuaj rau ib g |
Cov Ntaub Ntawv Thauj
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Chaw ua uas tsis tau haus |
Kev qhia tshwj xeeb |
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UN NUM |
2811 |
|
Hom |
6 |
|
Cov Pab Pawg |
I |
|
Hs code |
2933990099306 |
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Ruaj khov & rov ua |
Cov khoom lag luam ruaj khov nyob rau hauv cov qauv ambient ambient. |
|
Chaw ntim khoom |
Nruj nreem kaw. Qhuav. Khaws cia rau qhov chaw muaj cua zoo. Khib muab xauv los yog hauv ib qho chaw uas siv tau yooj yim rau cov neeg uas tsim nyog lossis tso cai. Kev khaws khoom ruaj khov Pom zoo pom zoo cia cua sov -20 - 0 degree |
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Mob kom tsis txhob |
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Lub thawv |
Cov ntaub ntawv raug
|
Chaw ua uas tsis tau haus |
Kev qhia tshwj xeeb |
|
Lub peev xwm |
1mt / hli |
|
Hov ntau |
|
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Lub teb chaws tseem ceeb |
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Peev Xwm / Batch |
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Paub lawm |
Ntau lawm txij xyoo 2015 |
|
Ntxiv rau |
Cov Ntawv Thov
1. Kev Kho Mob Cancer
Olaparib yog cov tshuaj tiv thaiv kab mob cancer siv hauv kev kho mob qog nqaij hlav uas cuam tshuam nrog Brca1 / 2 Gene kev sib hloov, suav nrog:
Kab mob kheesxaws zes qe (tshwj xeeb tshaj yog muab rov qab los yog platinum-rhiab)
Tus mob cancer mis (Her2-tsis zoo, Brca-mutated)
Prostate cancer (Metastatic castration-resistant prostate cancer)
Pancreatic Cancer (Metastatic Brca-Mutated hom)
Nws ib txwm siv raws li:
Monotherapy nyob rau hauv cov neeg mob uas muaj Brca sib hloov
Kev Kho Mob Khoos Phuam Tom Qab Platinum-Raws Li Kev Kho Mob
2. Ua ke kho
Olaparib yog nce tau kawm thiab siv ua ke nrog lwm cov neeg sawv cev tawm tsam mob qog nqaij hlav xws li:
Bevacizumab
Abiraterone
Lub cev tiv thaiv kab tiv thaiv tsis muaj zog inibitors
Cov kev sib xyaw ua ke no tsom rau kev txhim kho kev ua tau zoo los ntawm kev tawm tsam mob cancer los ntawm ntau yam mechanisms.
3. Kev Tshawb Fawb Kev Tshawb Fawb thiab Kev Tshawb Fawb
Siv dav hauv:
Cov chaw kuaj mob los ntsuas nws cov hauj lwm zoo hauv lwm cov qog
Tshawb saib nws lub synergy nrog radiotherapy thiab DNA-ua kom cov neeg sawv cev
Kawm cov ntawv thov hauv tsis-brca thiab hrd-zoo (homologous recombination tsis txaus) qog
Cov txiaj ntsig
✅ Lub Hom Phiaj
Tshwj xeeb tshwj xeeb cuam tshuam rau cov qog nqaij hlav cancer nrog kev kho DNA uas tsis zoo DNA thaum tau hais tawm cov hlwb zoo, txo cov kev lom zem.
✅ Exolongs ua kom tiav-muaj txoj sia nyob dawb
Loj hlob zuj zus kev ua kom muaj kev vam meej (PFS) hauv cov neeg mob brca-mutant cancer piv rau cov khoom noj lossis cov tshuaj kho mob ib leeg.
Qhia Txog Kev Sib Ntsib
Muaj cov ntsiav tshuaj yooj yim li yooj yim, uas txhim kho tus neeg mob ua raws thiab lub neej zoo.
✅ Tsis yog tshuaj kho kev xaiv
Muab ib txoj kev xaiv-cytotoxic rau kev txij nkawm ntev, feem ntau ncua qhov xav tau kev kho mob ntau dua.
✅ nthuav dav qhia
Pom zoo rau ntau hom cancer, thiab txuas ntxiv cov lus qhia tias muaj peev xwm nthuav dav dav rau lwm cov qog ua si.
Tag
Olaparib (CAS63113-22--0) yog ib qho chaw ua pa tawm inhiboritor uas ua lub luag haujlwm tseem ceeb nyob rau hauv precision atcology. Los ntawm kev tshawb nrhiav tsis muaj zog hauv DNA kho txoj hauv kev ntawm cov mob hlwb, nws muaj txiaj ntsig zoo, tsom rau cov neeg mob brca kev sib hloov lossis cov qog-zoo. Nws kev loj hlob siv ntau hom kabmob kheesxaws, cov yeeb yam tswj hwm txoj kev, thiab kev tshawb fawb ua rau nws lub pob zeb ua rau muaj mob qog nqaij hlav cancer niaj hnub no.
Cim npe nrov: Olaparib 丨 763113-22-0, Tuam Tshoj Oranaparib 丨 CAS 763113-22-0 tuam ntxhab, lwm tus neeg, Hoobkas
