Cov lus qhia
| Kev tshwm sim | Dawb rau tawm - hmoov dawb |
| Kev coj dawb huv | 98% min |
| Daim qhia npe | HNYMR |
Cov Ntawv Thov
Monomethyl authentatin E (MMAE) yog hluavtaws derivative ntawm dolastatin 10, tus neeg sawv cev tshuaj tiv thaiv xov tooj los ntawm kev thaiv tubulin polymerization. Vim nws cov tshuaj lom neeg siab, MMAE tsis siv los ua cov tshuaj tiv thaiv kev noj tshuaj tab sis yog hloov cov tshuaj tiv thaiv moniecodon- kev siv tshuaj conjugates (ADCS). Cov ADCS no tau tsim los kom xa cov cytotoxic tus neeg sawv cev ncaj qha rau cov qog nqaij hlav cancer, yog li no tsis tshua muaj kev puas tsuaj rau cov ntaub so ntswg. MMAE tau siv hauv kev txhim kho ADCS hom phiaj ntau yam mob qog nqaij hlav, suav nrog Lymphoma, Cancer mis, thiab ncauj tsev menyuam kab mob cancer mis, thiab ncauj tsev menyuam. Ceeb toom ADCS Inject incorporating MMA suav nrog Brenuximab Vedotin (Hom Phiaj CD30) thiab Tisotumab Vedotin (Hom Phiaj Ntaub Nqaij).
Cov txiaj ntsig
Kev siv MMAE hauv ADCS muaj ntau qhov zoo:
Ua kom muaj kev ua haujlwm anticator: MMAE cov khoom pov thawj siab cytooxicity, nrog rau IC50 ntawm tsawg dua 1 nm tawm tsam ntau yam kab mob cancer ntawm kab hauv nws cov chav kawm.
Lub Hom Phiaj Xa: Los ntawm conjugating mmae rau monoclonal Antibodies, ADCS tuaj yeem xa cov qog nqaij hlav cytotoxic rau cov hom phiaj cytotox
Kev kov yeej tsis kam: MMAH's Achchism ntawm kev ua tso cai rau nws ua haujlwm tiv thaiv cov qog uas tau tsim kev tiv thaiv mus rau cov neeg siv tshuaj kho mob ib txwm muaj.
Tag
Monomethyl autistatin e yog ib tug muaj zog antimitotic tus neeg sawv cev uas, thaum txuas rau cov tshuaj tiv thaiv monoclonal, cov qauv tsim Adcs ua tau zoo rau kev kho cancer. Nws lub peev xwm los xa cytoToxic cov neeg sawv cev ncaj qha rau cov tshuaj pleev rau cov qog ua kom muaj kev kho kom zoo thaum tsis muaj kev puas tsuaj rau cov ntaub so ntswg. Kev txhim kho ntawm MMAE -} Raws ADCS sawv cev rau txoj kev nce qib tseem ceeb hauv cov tswv yim kho mob cancer.
Cim npe nrov: Monomethyl Auristatin E yog 474645-27-7, Tuam Tshoj Monomethyl Auristatin E yog 474645-27-7 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas
