Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov tuam txhab tshaj lij thiab cov neeg muag khoom ntawm lifitegrast丨cas 1025967-78-5 hauv Suav teb. Txais tos rau kev lag luam wholesale kev cai ua cov khoom lag luam ntawm tus nqi sib tw los ntawm peb lub hoobkas. Rau cov khoom pheej yig dua, tiv tauj peb tam sim no.
Specifications
| Yam khoom | Specification |
|---|---|
| Qhov tshwm sim | Dawb los yog tawm -dawb hmoov |
| Solubility | Yooj yim soluble hauv N, N-dimethylformamide; me ntsis soluble hauv methanol thiab acetonitrile; yuav luag insoluble hauv dej |
| Kev txheeb xyuas (IR) | Raws li qhov spectrum ntawm cov khoom siv |
| Kev txheeb xyuas (HPLC) | Lub sijhawm khaws cia ntawm qhov tseem ceeb ntawm qhov kev sim tshuaj ntsuam xyuas yog ua raws li cov lus qhia siv |
| Kev txheeb xyuas lub cev & tshuaj lom neeg | Cov tshuaj tiv thaiv zoo |
| Clarity thiab xim ntawm kev daws | Ntshiab thiab tsis muaj xim; yog tias xim tshwm, tsis tsaus dua li Yellow No.5 txheem tshuaj |
| Yam khoom (HPLC) | |
| LG-1-B | Tsawg dua lossis sib npaug li 0.1% |
| LG-1-D | Tsawg dua lossis sib npaug li 0.1% |
| LG-C | Tsawg dua lossis sib npaug li 0.1% |
| 1121A | Tsawg dua lossis sib npaug li 0.1% |
| Lwm tus neeg impurities | Tsawg dua lossis sib npaug li 0.1% |
| Tag nrho impurities | Tsawg dua lossis sib npaug li 1.0% |
| Enantiomer | Tsawg dua lossis sib npaug li 0.15% |
| Dej | Tsawg dua lossis sib npaug li 3.0% |
| Residue ntawm ignition | Tsawg dua lossis sib npaug li 0.1% |
| Hnyav hlau | Tsawg dua lossis sib npaug li 20 ppm |
| Sulfate | Tsawg dua lossis sib npaug li 0.01% |
| Chloride | Tsawg dua lossis sib npaug li 0.01% |
| Assay (raws li anhydrous hauv paus) | 98.0% – 102.0% |
| Cov kab mob endotoxin | Tsawg dua lossis sib npaug li 3 EU / mg |
| Solvent Residue 1 | |
| Methanol | Tsawg dua lossis sib npaug li 0.3% |
| Ethanol | Tsawg dua los yog sib npaug li 0.5% |
| Acetone | Tsawg dua los yog sib npaug li 0.5% |
| Cov tshuaj acetonitrile | Tsawg dua lossis sib npaug li 0.041% |
| Dichloromethane | Tsawg dua lossis sib npaug li 0.06% |
| Ethyl acetate hmoov | Tsawg dua los yog sib npaug li 0.5% |
| Benzene | Tsawg dua lossis sib npaug li 0.0002% |
| Di-tert-butyl dicarbonate | Tsawg dua lossis sib npaug li 0.1% |
| Solvent Residue 2 | |
| N, N, N, N -Tetramethylethylenediamine | Tsawg dua lossis sib npaug li 0.1% |
| N,N{0}}Dimethylformamide | Tsawg dua lossis sib npaug li 0.088% |
| Methyl tert -butyl ether | Tsawg dua los yog sib npaug li 0.5% |
| Tetrahydrofuran | Tsawg dua lossis sib npaug li 0.072% |
| Ethylene glycol dimethyl ether | Tsawg dua lossis sib npaug li 0.1% |
| Trimethylsilyl acetylene hmoov | Tsawg dua lossis sib npaug li 0.1% |
| Triethylamine | Tsawg dua los yog sib npaug li 0.5% |
| N,N{0}}Disopropylethylamine | Tsawg dua lossis sib npaug li 0.1% |
| n-Heptane | Tsawg dua los yog sib npaug li 0.5% |
| Acetic acid | Tsawg dua los yog sib npaug li 0.5% |
| Dimethyl sulfoxide | Tsawg dua los yog sib npaug li 0.5% |
| Aerobic cov kab mob suav | Tsawg dua lossis sib npaug li 10 cfu / g |
| Pwm & poov xab suav | Tsawg dua lossis sib npaug li 100 cfu / g |
| Escherichia coli | NP / 1 g |
| Pseudomonas aeruginosa | NP / 1 g |
Daim ntawv thov
Lifitegrast feem ntau yog siv nyob rau hauv ophthalmology raws li ib tug active tshuaj muaj nyob rau hauv kev tswj ntawm qhuav qhov muag kab mob. Nws yog formulated nyob rau hauv tshuaj pleev ophthalmic daws tsim rau ocular tswj ncaj qha, qhov twg nws ua nyob rau hauv lub zos ntawm lub ocular nto. Lifitegrast yog siv los txo qhov mob uas cuam tshuam nrog lub qhov muag qhuav ntev los ntawm kev tsom mus rau kev tiv thaiv kab mob -txoj kev sib kho uas ua rau tsim kua muag tsis ruaj khov thiab qhov muag tsis pom kev. Tshaj li kev siv tshuaj kho mob, nws kuj tseem ua haujlwm hauv kev tshawb fawb tshuaj thiab kev txhim kho los kawm txog cov teeb meem kev mob tshwm sim ntawm lub ntsej muag, nrog rau hauv kev tshawb fawb txog kev ua kom zoo tshaj plaws rau kev xa tshuaj, bioavailability, thiab tolerability hauv qhov muag -poob npaj.
Cov txiaj ntsig
Lifitegrast muaj ntau qhov zoo vim nws lub hom phiaj ntawm kev ua haujlwm thiab tsim nyog rau kev kho mob hauv zos. Los ntawm kev xaiv inhibiting kev sib cuam tshuam koom nrog hauv inflammatory cell activation, nws pab txo qhov mob ntawm lub qhov muag, alleviating cov tsos mob xws li dryness, irritation, thiab pom kev cuam tshuam. Nws cov kev tswj xyuas cov tshuaj tso cai rau kev ua tau zoo hauv zos nrog qhov cuam tshuam tsawg kawg nkaus, txhawb nqa kev nyab xeeb thiab kam rau ua qhov profile. Lifitegrast qhia tau hais tias kev ua tau zoo ib yam hauv kev txo cov cim qhia thiab cov tsos mob ntawm cov kab mob qhov muag qhuav, thiab nws cov tshuaj ruaj khov ua kom muaj kev txhim khu kev qha thiab khaws cia hauv cov khoom muag muag. Cov yam ntxwv no ua rau nws zoo haum rau lub sijhawm ntev - kev tswj xyuas cov kab mob ocular.
Xaus
Lifitegrast yog ib qho tseem ceeb kho tus neeg sawv cev hauv kev kho mob ntawm qhov muag qhuav, nrog rau kev siv lub hauv paus ntawm kev txo cov qhov muag qhov muag thiab txhim kho cov kua muag yeeb yaj kiab. Nws cov txiaj ntsig, suav nrog cov phiaj xwm hauv zos, kho cov tsos mob zoo, thiab tsim nyog rau cov tshuaj ophthalmic formulations, ua rau nws yog ib qho tseem ceeb ntawm kev kho qhov muag niaj hnub. Cov tshuaj txuas ntxiv txhawb kev nce qib hauv kev kho mob ophthalmic thiab kev tshawb fawb tsom mus rau qhov muag tsis pom kev.
Cim npe nrov: Lifitegrast 1025967-78-5, Tuam Tshoj lifitegrast 丨cas 1025967-78-5 manufacturers, lwm tus, Hoobkas
