Cov lus qhia
| Qib: | USP-NF2024 |
| Zog: | Muaj xim tsis muaju lossis cov hmoov dawb dawb |
| Assisy (qhuav yeeb tshuaj): | 98.0%~102.0% |
| Daim qhia npe: | 1) sib piv nrog cov spectrum tau nrog CRS 2) Lub sijhawm ua haujlwm ntawm qhov kev daws teeb meem loj ntawm cov kev daws teeb meem sib raug zoo rau ntawm cov qauv kev daws teeb meem, raws li tau txais hauv cov assay |
| Poob rau ziab: | 1.0% max |
| Residue ntawm ignition: | 0.15% Max |
| Related tshuaj: | (1) Impurity A: 0.05% Max (2) Tus neeg tsis paub txog Impurity: 0.05% Max (3) Tag nrho cov impurities: 0.1% Max |
Cov Ntawv Thov
1. Siv Tshuaj Siv
Keeb kwm siv raws li qhov tsis-opioid analgesic thiab antipyretic kom txo qhov mob thiab kub taub hau.
Nws cov khoom analgesic thiab antipyretic cov khoom ua rau nws ua qauv rau kev txhim kho ntawm lwm cov tshuaj tsis yog-steroidal anti-inflammatory).
Siv nyob rau hauv cov chaw kuaj mob uas yog cov cim tshuaj ntsuam xyuas kom lub siab thiab yeeb tshuaj metabolism, tshwj xeeb yog Cytochrome P450 enzyymes.
2. Biochemical thiab Tshawb Fawb
Ua haujlwm raws li kev sojntsuam tshuaj rau kev kawm hepatic enzyme muaj nuj nqi vim yog nws cov kev ua tau zoo li qub.
Siv nyob rau hauv vitro thiab hauv Vivo Metabolism kev tshawb fawb los ntsuas kev ua yeeb yam tshuaj-metabolizing enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymes enzymia.
3. Kev txheeb xyuas Chemiser
Ua txhaum raws li kev siv txuas rau hauv kev ua kom zoo ua kua chromatography (HPLC) thiab lwm txoj kev ntsuas.
Siv hauv kev sim thiab ntsuas kom zoo rau nws cov khoom zoo.
Cov txiaj ntsig
1. Cov yeeb yaj kiab zoo tshaj plaws
Cov metabolism ntawm cov tshuaj tua kab mob tau nkag siab zoo, ua kom muaj kev nkag siab zoo rau daim siab ua kom daim siab thiab siv tshuaj yeeb.
2. Kev Tshawb Fawb Txog Kev Tshawb Xyuas
Nws siv ua cov kws tshawb fawb cov kws tshawb fawb los kawm cov tshuaj meticolism hloov pauv hauv cov pejxeem sib txawv lossis hauv cov xwm txheej sib txawv.
3. Ruaj khov thiab yooj yim tuav
Antipyrine yog kev ruaj khov kho thiab tsim tau yooj yim los tsim hauv kev tshawb nrhiav kev ntsuas.
Tag
Antipyrine (CAS 60 -80-0-0) yog ib qho pyrazolone derivative nrog keeb kwm kev siv raws li analgesic tus neeg sawv cev. Niaj hnub no, nws tus nqi tseem ceeb nyob hauv kev tshawb fawb thiab biochemical kev tshawb fawb raws li kev sojntsuam rau daim siab enzyme kev ua si thiab yeeb tshuaj metabolism. Nws cov khoom siv metabolic thiab tshuaj ruaj khov ua rau nws muaj qhov tsis tseem ceeb ntawm cov chaw muag tshuaj hauv cov chaw muag tshuaj thiab kev tshawb fawb toxicological.
Cim npe nrov: Antipyrine yog 60 -80-0, Suav, Tuam Tshoj Antipyrine 丨 CAS 60-80-0 tuam ntxhab, cov chaw muag khoom, Hoobkas
