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Cov lus qhia tshwj xeeb ntawm Dabrafenib 丨 CAS 11 11 CAS 1195765-45-7
|
Kev tshwm sim |
Tawm-Dawb Khoom |
|
Kev coj dawb huv |
99% min |
|
Zoo siab |
99.0% min |
|
Daim qhia npe |
Cov kev sib nqus Nuclear sib xyaw cov ntaub ntawv ntawm cov khoom no yuav tsum sib xws nrog cov ntawv sau |
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Dej |
1.0% max |
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Hais txog impurities |
1.0% max |
Tshuaj Txheej txheem:
DabBRF V600E Kinase, ib qho kev sib raug zoo ntawm cov prof muaj protein feem ntau cuam tshuam nrog qee yam mob cancer. Nws zwm rau chav kawm ntawm cov kev kho mob cancer uas hu uakinease inibitorsCov. Dabranfenib yog kev lag luam nyob rau hauv lub npe lag luamTafinlar®, feem ntau yog ua ke nrog lwm tus neeg sawv cev xws li trametinib.
Cov Ntawv Thov
Tsom cancer kho mob cancer
DabBRF V600 Meej, suav nrog:
Melanoma: Rau unresectable lossis metastatic melanoma nrog braf v600E mutation (feem ntau siv ua ke nrog trametinib).
Tsis yog-me me cell mob cancer (NSCLC): Rau Metastatic NSCLC nrog Braf V600E mutation.
Anapastic Thyroid Cancer (ATC): Rau cov mob tsis tshua muaj siab, muaj kev kub ntxhov ntawm kev sib cav sib ceg.
Low-qib glioma (pediatric siv): Pom zoo rau Braf V600E kev sib hloov-zoo.
Kev Kho Mob nrog Trametinib
Dabranfenib feem ntau siv nrogtsheb huv, ib tug mek inhibitor, los txhim kho kev ua tau zoo thiab txo kev tiv thaiv. Qhov no dual thaiv ntawm Mapk / Erk txoj kev ua tiav hauv kev tswj cov qog ua kom muaj kev txhawb nqa cov qog.
Kev Tshawb Nrhiav thiab Kev Tsim Tshuaj
Dab Neeg Daj
Cov txheej txheem ntawm cov yeeb tshuaj tsis kam rau mob cancer.
Daim paib hloov chaw nyob rau Ras-Raf-Mek-erk txoj kev.
Syergistic cuam tshuam nrog kev tiv thaiv kab mob thiab lwm tus neeg sawv cev.
Cov txiaj ntsig
Kev xaiv thiab muaj zog inhibition
Dabrafenib 丨 CAST 1195765-45-7 PENYUAM HOM PHIAJ LUB HOM PHIAJ SOLDED BRAF V600E Kinase, tso cai rauPrecision Kev Kho Mobuas txo cov teebmeem kev cuam tshuam piv rau cov tshuaj khomob uas muaj kev sib xyaw.
Txhim kho kev loj hlob-muaj txoj sia nyob dawb
Hauv kev sim tshuaj sim, Dabrafenib tau qhiaQhov tseem ceeb txhim kho hauv kev muaj txoj sia nyob dawb thiab tag nrho ciaj siaRau cov neeg mob nrog Braf-mutant Melanoma, tshwj xeeb tshaj yog ua ke nrog trametinib.
Thawj coj
Dab Neeg Dajrafenib yog muab kev tswj hwm thiab kev kho kom yooj yim thiab tsis muaj kev kho mob uas tsis muaj kev phom sij rau cov neeg mob.
Txo cov kev mob tshwm sim piv rau cov tshuaj kho mob
Raws li lub hom phiaj kho, tsis muaj ib txwm muajXav paub ntau ntxiv kev nyab xeeb profileRaws li kev siv tshuaj ib txwm muaj, nrog cov kev mob tshwm sim ntau dua rau pob khaus tawv nqaij, ua npaws, thiab qaug zog.
Nthuav dav siv nyob rau hauv pediatric oncology
Nws kev pom zoo rau pediatric qis-qib glioma highlights Dabrafenib txoj haujlwm hloov zuj zus hauvTus Kheej Tshuaj Rau Cov Menyuamnrog cov qog nqaij hlav caj dab.
Txoj kev muaj mob cancer tshwj xeeb
Los ntawm phiaj rau ntawm Mapk / erk txoj kev, Dabrafenib tsis tsuas yog pab cuam qog txoj kev loj hlob tab sis kuj tseem yuav tiv thaiv cancer cell muaj sia nyob rau hauv braf-mutant hlav.
Lub ntsiab
Dabrafenib 丨 CAST 1195765-45-7 yog muaj zog thiab xaiv braf inhibitic siv nyob rau hauv kev kho mob ntawm cancer-cov qog nqaij hlav v600E, suav nrog Melanoma, NSCLC, thiab anaproid cancer. Raws li lub pob zeb ntawm cov kev kho mob niaj hnub, tshwj xeeb hauv kev ua ke nrog Trametinib, Dabrafenib muaj cov txiaj ntsig zoo, tswj tau cov tshuaj lom neeg, thiab kev sib tw ntawm qhov ncauj yooj yim. Nws sawv cev rau lub paradigm hloov mus rauPrecision Oncology, tsom rau cov neeg tsav tsheb caj ces mob cancer.
Cim npe nrov: Dabrafenib 丨 CAST 1195765-45-7, Tuam Tshoj Dabrafenib 丨 CAST 1195765-45-7 tuam ntxhab, cov chaw tsim khoom, Hoobkas
