Cov lus qhia
| Zog: | dawb lossis tawm dawb hmoov |
| Assay (xam los ntawm dawb alkali): | 66-72% |
| TSHWJ XEEB ROFTCER ROTIONATION: | +9 rau +14 deg |
| Daim qhia npe: | Lub sijhawm ua haujlwm ntawm qhov kev daws teeb meem loj ntawm cov qauv daws teeb meem rau cov txheej txheem kev daws teeb meem, raws li tau txais hauv diastereoisomer (tshem tawm cov kuab tshuaj ncov qaum (tshem tawm cov ntaub pua chaw sab nrauv). IR Spectrum coj mus kuaj yuav tsum muaj concordant nrog lub spectrum ntawm tus qauv |
| Dej: | 1.0% max |
| Trifluoroacetic acid: | 28-32% |
| Diastereeoisomer: | 0.2% max |
| Enantiomer: | 0.2% max |
| Isoblutyl bromide: | 0.1% Max |
| 3-methyl butylamine: | 1.0% max |
| Dichhloromethane: | 0.06% max |
| Methyl tert-butyl ether: | 0.5% max |
| Hexane: | 0.029% Max |
| Isopropyl ether: | 1.0% max |
| TetrahyDrofuran: | 0.072% Max |
| N-heptane: | 0.5% max |
| Methyl Cyclohexane: | 0.118% Max |
| Ethyl Benzene: | 0.5% max |
Cov Ntawv Thov
1. Asymmetric synthesis
Siv los ua lub tsev chairal thaiv lossis reagent hauv enantioselective synthesis los qhia chairal chaw.
Pab txhawb cov pa roj carbon-carbon carbon-carbon pab pawg, xws li hauv kev sib cav, alkylation, thiab cov tshuaj lom neeg.
Lub chiral boronate ester moiety muab cov stereocontrol, tseem ceeb rau synthesizing enantiomerically encounds hauv cov chaw tshuaj thiab tshuaj zoo.
2. Chiral Ntu lossis Ligand Preursor
Ua hauj lwm ua chiral ib pab pawg lossis ligand ua ntej hauv catalytic asymmetric tshua.
Tuaj yeem tswj cov hlau lossis koom nrog hauv cov catalytic mus rau hauv cov chairrality hauv phiaj lwg me me.
3. Khoom cua ntawm chairal amino acid derivatives
Siv nyob rau hauv kev npaj ntawm chiral amino acids foralogs, xws li boron-muaj cov leucine derivatives, uas muaj txiaj ntsig hauv kev siv tshuaj chemistry.
Cov boron-hloov kho cov amino acids tuaj yeem ua cov enzyme inhibitors, molecular pretes, lossis lub tsev thaiv kom muaj kev ua si nrog kev txhim kho roj ntsha.
4. Tshuaj thiab Tshuaj Txha Ntawv Chemistry
Qhov tseem ceeb Intermediate nyob rau hauv cov synthesis ntawm boron-muaj cov tshuaj, suav nrog cov neeg tsis muaj kev tiv thaiv thiab anticancer cov neeg sawv cev.
Cov tswj kev nyab siab chairality yog tseem ceeb rau tshuaj uas muaj kev ua tau zoo thiab txo cov kev mob tshwm sim.
Cov txiaj ntsig
1. Cov Entantioselectivity
Lub compound ua rau cov hloov pauv tau zoo ntawm chairality hauv synthesis, muab cov enantiomic ntau dhau hauv cov khoom lag luam.
Pinanediol kev tiv thaiv ruaj khov lub coron Center, txhim kho kev xaiv tau.
2. Txhim kho qhov ruaj khov thiab kov
Tus Pinanediol Boronate Ester Form yog cov txheej txheem ruaj khov thiab yooj yim dua los lis cov kua roj dawb dua li cov neeg thoronic.
Lub trifluoroacetate ntsev tsim txhim kho solubility thiab tshuaj tiv thaiv tswj.
3. Versatility hauv Synthesis
Siv tau nyob rau hauv ntau cov kev hloov pauv asymmetric.
Tso cai rau kev nkag mus rau cov nyom chairules nrog kev tswj hwm cov ua ke.
4. Kev txhawb nqa tshuaj
Txhawb cov synthesis ntawm chirally ntshiab intermediates rau cov chaw ua tshuaj.
Txhim kho qhov muaj peev xwm rau cov neeg sib tw hauv cov neeg sib tw nrog cov kev sib tw txhim kho roj ntsha.
Tag
(R) -boroleu - (+) - Pinanediol trifluoroacetate (CAS 179324-87-9) yog lub zog chiral boron rau siv hauv enantioselective organic synthesis. Nws cov qauv tshwj xeeb, sib txuas ua ke (R) -Lucine lub moj khaum nrog cov neeg pinanediol boronate ester thiab trifabicchemical tswj, ruaj khov, thiab khoom siv hluavtaws. Qhov no ua rau nws muaj txiaj ntsig zoo nyob rau hauv kev tsim cov chariral amino acid derivatives, boron-muaj cov kws kho mob, thiab ligand prefursor hauv catrealytic asymmetric.
Cim npe nrov: (r) -boroleu - (+) - Pinanediol Trifluoroacetate 丨 CAS 179324-87-9 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas
