Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov kws tshaj lij thiab cov neeg muag khoom ntawm sparsentan 丨cas 254740-64-2 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo tshuaj cov khoom ntawm kev sis tw nqi los ntawm peb lub hoobkas. Yog tias koj muaj lus nug txog kev pabcuam kev cai, thov koj xa email rau peb.
Specifications
| Qhov tshwm sim | Dawb rau tawm -dawb hmoov |
| Solubility | Soluble hauv DMSO |
| Kev txheeb xyuas | HPLC / HNMR |
| Particle Loj | D90 < 150 μm |
| Residue ntawm Ignition | 0.2% max |
| Hnyav Hlau | 10 ppm max |
| Poob rau ziab | 0.5% max |
| Cov ntsiab lus dej | 0.5% max |
| Yam khoom muaj feem | |
| Max tus kheej impurity | 0.5% max |
| Tag nrho impurities | 1.0% max |
| Residual Solvents | |
| Ethanol | 5000 ppm max |
| Isopropanol | 5000 ppm max |
| Dichloromethane | 600 ppm max |
| Kev ntsuam xyuas (HPLC) | 98.0% – 102.0% |
Daim ntawv thov
Sparsentan feem ntau yog siv rau hauv kev kho mob raum kab mob, tshwj xeeb tshaj yog focal segmental glomerulosclerosis (FSGS) thiab IgA nephropathy, qhov uas nws pab txo cov proteinuria thiab qeeb cov kab mob. Nws ob lub tswv yim ntawm kev ua haujlwm ua rau nws muaj txiaj ntsig zoo dua li ib txwm ib txwm siv - txoj kev kho mob hauv kev tswj cov glomerular raug mob thiab fibrosis. Hauv kev tshawb fawb soj ntsuam thiab tshuaj, sparsentan ua haujlwm ua qauv sib xyaw rau kev txhim kho tom ntej - tiam dual receptor antagonists tsom rau ob qho tib si renin-angiotensin system thiab endothelin txoj hauv kev. Nws kuj tseem kawm txog cov ntawv thov muaj peev xwm hauv lwm cov mob fibrotic thiab cov hlab plawv, qhov uas ua ke inhibition ntawm vasoconstrictive thiab proliferative signaling txoj kev tuaj yeem muab cov txiaj ntsig kho mob.
Cov txiaj ntsig
Cov txiaj ntsig tseem ceeb ntawm sparsentan yog nyob rau hauv nws ob lub hom phiaj - lub hom phiaj mechanism, uas muab kev ua tau zoo dua piv rau ib leeg receptor blockers los ntawm kev hais txog ntau tus neeg tsav tsheb ntawm lub raum kev puas tsuaj ib txhij. Qhov no ua rau kom txo qis ntawm cov proteinuria, khaws cia zoo dua ntawm lub raum ua haujlwm, thiab muaj peev xwm ua kom qeeb ntawm cov kab mob. Raws li kev hais lus me me molecule, nws muaj kev tswj hwm yooj yim thiab ua raws li tus neeg mob zoo. Nws lub hom phiaj pharmacological profile txo qhov kev xav tau ntawm kev kho mob sib xyaw ua ke, muaj peev xwm txo qis kev sib cuam tshuam tshuaj thiab ua kom yooj yim rau kev kho mob. Tsis tas li ntawd, nws txoj kev loj hlob sawv cev rau kev nce qib hauv cov tshuaj precision, muab cov kev xaiv zoo dua rau cov neeg mob uas tsis tshua muaj thiab nyuaj- rau- kho cov kab mob raum.
Xaus
Sparsentan yog ib qho tshiab dual receptor antagonist nrog cov peev xwm kho mob tseem ceeb hauv kev kho mob raum kab mob, tshwj xeeb tshaj yog cov kab mob glomerular tsawg. Nws lub peev xwm los ua ke inhibit angiotensin thiab endothelin txoj hauv kev muab cov txiaj ntsig kho mob tau zoo dua qub thiab sawv cev rau kev nce qib hauv kev kho mob raum. Raws li kev tshawb fawb txuas ntxiv nthuav dav nws cov ntawv thov, sparsentan sawv tawm raws li cov tshuaj cog lus nyob rau hauv kev hloov kho toj roob hauv pes kho mob raum thiab mob plawv.
Cim npe nrov: Sparsentan 丨cas 254740-64-2, Tuam Tshoj sparsentan 丨cas 254740-64-2 manufacturers, lwm tus neeg, Hoobkas
