Sodium dichhloratate 丨 CAS 2156-56-1

Sdium Dichhlracetate 丨 {{2156-56-1 yog cov cranrinated rabginated regrinated smanic cmpund uas tau dav kawm frtertutic thiab bichemical prepties. Nws yog Sdium ntsev f dichhlracetic acid (DCA) thiab tau nyiam cov lus qhia ntawm kev coj ua, tshwj xeeb los ntawm kev cuam tshuam lactate lactabism thiab mitchnydrial functin.
Mechanism ntawm Actin
Sdium Dichhlracetate 丨 {{2156-56-1} Muaj kev nthuav dav ntawm MDULATE Mev metabular, tshwj xeeb tshaj yog nyob rau hauv Cntum F lactate prductin thiab aerbic invitiratin.
Insibitin f pyruvate KinaseDr Grantdracetate Kinase Dichhlracetate 丨 {}}}} {) enzydrenates, uas nyeg pyruvate dehydredrenase (Pyruvate Dehydredrenase (PDH). Qhov no ua rau Cnversin F pyuvate rau cov acetyl-ca, uas nkag mus rau Kres lub voj voog (TCA voj voog (TCA lub voj voog) frčnndria. Qhov kev hloov ua haujlwm no frm Anaerbic Glyclysis t Aerbic kev coj ua hauv CNDITIN qhov twg lactate concumulatin thiab hypxia ccur.
● Cov duab hluav taws xob roj av uas tsawg dua qub
● MitchTndrial Functin: SDium Dichhlracetate 丨 2156-56-1}} Tau ua rau lub ntsej muag psphdrial psphydratin, uas ua rau T Mre ua tau zoo ATP PrDDuctin. Qhov no tuaj yeem kho tau pteferic nyob rau hauv cov kab mob uas mitchndrial dysfunctin yog ib tug femtretreeritive kab mob r cancer.

1.Cancer Kev Kho Mob:
Kev sib tw Tumr metabism: SDium Dichhlracetate 丨 2156-56-1 Tau txais paj cancer cancer fram anaerbic glyclysis (lub warburg nyhuv) t aerbic inpiratin. Ntau cov kabmob kheesxaws cia nkaus nkaus n glyclysis n glyclysis f zog prductin, txawm tias nyob rau hauv lub xub ntiag f yog foog (knwn raws li lub warburg nyhuv). Los ntawm prmting mitchndrial xiditive phsphriclatin, sdium dichhlracetate Culd Txo Tumr Grwth thiab Metastasis.
Cov kev tshawb fawb soj ntsuam: Ntau cov kev sim tshawb fawb thiab preclinical kev tshawb fawb tau pom zoo tias s slid tumrs thiab txo tus ciaj sia fanceg thiab txo tus ciaj sia fanceg. Hwever, MRE kev tshawb nrhiav yog qhov xav tau nkag siab txog nws txoj cai thiab ua haujlwm tau zoo rau kev kho mob cancer.
2.lem acidsis:
Kho f lactic f licyl acidsis: sdium dichhlracetate yog siv los ua kev sim tshuaj lactic, ib cnditin f lactic acid nyob rau hauv bldstream. Cov cnditin no tuaj yeem ua rau cov dev tsis zoo me ntsis, hypxia, r tej tshuaj. Los ntawm kev txhim kho pyruvate metablism thiab txo lactate prductin, sdium dichhlracetate tuaj yeem pab tau creteescic tsis txaus ntseeg.
3.MitchNdrial kab mob:
Neurdegenerative kab mob: SME kev tshawb nrhiav tau tshawb xyuas qhov ptential fichhlracetate hauv kev kho f mitchndrial psphrial psphratin. Cov kab mob xws li Alzheimer tus kab mob, chaw ua si Parkinsn tus kab mob, thiab Amytrphic Lawb tawm hauv kev txhim kho MitchNdrial ATP PrDuctin thiab Prmting Aerbic kev dag ntxias.
Cellular Lub Zog Defagicencies: Hauv CNDITIN qhov chaw uas muaj qhov tsis txaus siab fysfunctin, SDium Dichhlracetate tuaj yeem pab txhawb zog ua kom muaj zog prductin hauv cov ntaub so ntswg thiab cov ntaub so ntswg.
4.Diabes:
SME kev tshawb fawb qhia tias Sdium Dichhlracetate yuav muaj ptential nyob rau hauv hom ntshav qab zib hauv hom 2 tus ntshav qab zib los ntawm imply actulin rhiab heev thiab glyclytic metablism. Nws tuaj yeem pab cov nyiaj tau los ntawm cov kab mob ntshav qab zib ntawm cov kab mob ntshav qab zib (althugh nws siv fr no purpse yuav tsum tau tshawb nrhiav ntxiv.
5.Acid-hauv qab tshuav:
Sdium Dichhlracetate 丨 {{2156-56-1 Kuv tuaj yeem siv tau los ntawm QNDENSIDE zoo li Chrnic Mobile tus kab mob thiab cov kua qaub.

1.Targeted metabolic cov nyhuv:

Sodium Dichloroacetate 丨 {{2156-56-1 muaj kev ua haujlwm zoo nkauj rau cov kab mob me me uas muaj kab mob cuam tshuam nrog cov kab mob metabolic.

2.Reduction ntawm lactic acid:

Los ntawm kev txo lactate ntau lawm, cov sodium dichloroacetate 丨 {{} tuaj yeem pab txo cov kab mob acidosed, cov qog nqaij hlav, thiab cov qog nqaij hlav.

3.Cancer kho mob:

Nws lub peev xwm cuam tshuam rau kev cuam tshuam harburg thiab hloov hluav taws xob ntau rau kev sib tw tiv thaiv mob qog noj ntshav, qhov chaw uas metabolic rewiring yog lub cim ntawm malignancy.

4.mitochondrial txhawb:

Nws muaj peev xwm txhim kho mitochondrial muaj nuj nqi, uas yuav tau txais txiaj ntsig zoo hauv kev kho mob neurodegener, thiab lwm yam kev tsis sib haum xeeb uas mitochondrial hluav taws xob ntau dhau yog nyom.

5.Tow Toxicity:

Sodium Dichhloroacetate yog feem ntau suav hais tias muaj cov tshuaj lom tsawg dua piv rau lwm cov kws kho mob, ua rau nws muaj kev nyab xeeb rau kev tshawb nrhiav ntxiv hauv cov chaw kuaj mob.

Sodium Dichloroacetate 丨 {2156-56-1 yog cov peev xwm metabolic nrog cov kab mob metabolic nrog cov kab mob metabolic, mob cancer, thiab cov kab mob mitochonds. Los ntawm kev hloov pauv pyruve metabolism thiab txhim kho mitochondrial muaj nuj nqi los kho cov xwm txheej uas yog cov metalis lub luag hauj lwm. Thaum lub sij hawm cov compound qhia tau cog lus hauv ntau qhov chaw kho, nws siv yuav tsum ua tib zoo saib xyuas vim muaj kev mob siab. Kev tshawb fawb txuas ntxiv yog xav tau los tsim nws txoj kev nyab xeeb thiab kev ua tau zoo hauv kev tshawb fawb.