Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov kws tshaj lij thiab cov neeg muag khoom ntawm sacubitril sodium 丨cas 149690-05-1 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo tshuaj cov khoom ntawm kev sis tw nqi los ntawm peb lub hoobkas. Yog tias koj muaj lus nug txog kev pabcuam kev cai, thov koj xa email rau peb.
Specifications
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Qhov tsos: |
Dawb los yog tawm -dawb hmoov |
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Kev ntsuam xyuas: |
98.0% ~ 102.0% (anhydrous khoom) |
|
Kev txheeb xyuas: |
Lub Sijhawm Khaws Cia: Zoo ib yam li Cov Khoom Siv IR: Zoo ib yam li Cov Khoom Siv Cov khoom no qhia cov nplaim hluav taws xob ntawm sodium ntsev X-ray diffraction qauv muaj peaks ntawm 2 theta: 6.2℃± 0.2 degree, 19.9℃± 0.2 degree, 21.5℃± 0.2 degree |
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Na: |
4.1% ~ 6.5% (anhydrous khoom) |
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Dej: |
5.0% max |
Yam khoom
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SX-9-D: |
0.15% max |
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SX-9-F: |
0.15% max |
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Ib qho impurity: |
0.10% max |
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Tag nrho impurities: |
1.0% max |
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Isomer |
|
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SX-9-A: |
0.15% max |
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SX-9-B: |
0.15% max |
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SX-9-C: |
0.15% max |
Isomer
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SX-9-A: |
0.15% max |
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SX-9-B: |
0.15% max |
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SX-9-C: |
0.15% max |
Residual Solvents 1
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Ethanol: |
0.5% max |
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Dichloromethane: |
0.06% max |
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n-Hexane: |
0.029% max |
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Ethyl acetate: |
0.5% max |
Residual Solvents 2
|
Methyl Tertiary Butyl Ether: |
0.5% max |
|
Isopropyl acetate hmoov: |
0.5% max |
Cov ntaub ntawv thauj mus los
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Parameter |
Specification |
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UN Number |
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Chav kawm |
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Packing Group |
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HS Code |
2933990099307 |
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Stability & Reactivity |
Cov khoom yog chemically ruaj khov nyob rau hauv tus qauv ambient tej yam kev mob. |
|
Cia |
Khaws lub thawv kaw kom nruj rau hauv qhov chaw qhuav, txias thiab zoo - qhov cua. Cia sib nrug ntawm cov khoom ntim khoom noj lossis cov khoom siv tsis sib xws. |
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Qhov xwm txheej kom zam |
|
|
Pob |
Txheej txheem cej luam
Sacubitril Sodium 丨 CAS 149690-05-1 yog tussodium ntsevdaim ntawv ntawm sacubitril, ib tug prodrug uas yog metabolized nyob rau hauv lub cev mus rau nws active daim ntawv,qw 657. Nws yog qhov zoo tshaj plaws lub npe hu ua ib feem ntawm cov tshuaj ua kesacubitril / valsartan(hom npeEntresto), uas yog siv los khoplawv tsis ua hauj lwm.
Sacubitril yog ibNeprilysin inhibitor-nws thaiv cov enzyme neprilysin lub luag haujlwm rau degrading natriuretic peptides, yog li txhim kho lawv cov txiaj ntsig zoo ntawm cov hlab plawv.
Daim ntawv thov
1. Kev siv tshuaj hauv kev tswj lub plawv tsis ua haujlwm
Sacubitril Sodium ua ke nrog valsartan (ib qho angiotensin receptor blocker) los tsimEntresto, thawj-hauv- chav kawmangiotensin receptor neprilysin inhibitor (ARNI).
Qhia rau kev kho mob ntawmmob plawv tsis ua hauj lwm nrog txo ejection feem (HFrEF).
Txhim kho lub plawv ua haujlwm los ntawm:
Txhim kho cov qib natriuretic peptide (vasodilation, natriuresis, diuresis).
Txo kev kho mob plawv thiab fibrosis.
Txo cov ntshav siab.
Kev sim tshuaj ntsuam xyuas pom tias nws txo qis kev tuag thiab kev mus pw hauv tsev kho mob hauv cov neeg mob plawv.
2. Kev Tshawb Fawb thiab Kev Txhim Kho Tshuaj
Siv los ua cov tshuaj tseem ceeb hauv kev tshawb fawb tshawb nrhiav neprilysin inhibition thiab cov kws kho mob plawv.
Ua hauj lwm raws li cov ntaub ntawv siv los tsim cov tshuaj ARNI tshiab lossis cov kab mob plawv zoo sib xws.
Cov txiaj ntsig
Txhim kho cov txiaj ntsig kho mobHauv cov neeg mob plawv tsis ua haujlwm thaum ua ke nrog valsartan.
Muab ibdual mechanism ntawm kev ua(Neprilysin inhibition + RAAS blockade).
Pab txocov tsos mobthiabpheej hmoo mus pw hauv tsev kho mob.
Taw qhia txog kev nce qib tseem ceeb tshaj li kev kho mob plawv tsis ua hauj lwm.
Cov ntsiab lus
Sacubitril Sodium CAS 149690-05-1yog sodium ntsev ntawm sacubitril, aNeprilysin inhibitortseem ceeb hauv kev kho mob ntawmplawv tsis ua hauj lwmua ib feem ntawm cov tshuaj ua kesacubitril / valsartan (Entresto) kev kho mob. Nws txhim kho cov txiaj ntsig ntawm lub plawv los ntawm kev muaj zog natriuretic peptides thiab yog ib qho tseem ceeb molecule hauv kev tshawb fawb txog kev kho plawv.
Cim npe nrov: Tuam Tshoj sacubitril sodium 丨cas 149690-05-1, Tuam Tshoj sacubitril sodium 丨cas 149690-05-1 manufacturers, lwm tus neeg, Hoobkas
