Pyrrolo2,1-f1,2,4triazin-4-amine 丨 CAS 159326-68-8

Lub ntsiab

Pyrrolo2,1-f1,2,4triazin-4-amine 丨 CAS 159326-68-8 yog aKuas Nitrogen-Rust Heeteroccoxatthiab ib qho tseem ceebKws Tshuaj Nruab Nrab, tshwj xeeb tshaj yog nyob rau hauv kev loj hlob ntawm cov antiviral cov neeg sawv cev.

Cov Ntawv Thov

1. Tshuaj Nruab Nrab

Nucleoside analogs synthesis:
Pyrrolo2,1-f1,2,4triazin-4-amine 丨 CAS 159326-68-8 yog aCov Tseem Ceeb Tseem CeebHauv synthesis ntawmRemdesivir, muaj kev siv hluav taws xob dav dav siv rau covid-19 thiab lwm tus kabmob RNA.

Antiviral Yeeb Tshuaj:
Nws fused heterocyclic scaffold mimics pimics pimics bases (zoo li Adenine), ua rau nws muaj txiaj ntsig zoo hauvnucleoside analog tsimrau RNA polymerase inhibitors.

Muaj peev xwm siv nyob rau hauv oncology thiab antibacterial:
Lub triazine scaffold kuj tau kawm rau cov ntawv thov hauvAnticancer Cov Neeg Sawv Cevthiabenzyme inibitors, tshwj xeeb kinases.

2. Tshuaj Kho Mob Chemistry

Dav siv nyob rau hauvTus qauv-kev sib raug zoo (SAR) kev tshawb fawbRau kev tsim qauv purine biopososes los yog analogs nrog kev txhim kho metabolic ruaj khov lossis hloov kho cov kev xaiv tau.

Ua hauj lwmmoinityKev tsim kho cov me-molecule inhibitors hauvKev Ntsuas Cov Tshuaj Tiv Thaiv Highputputputment.

3. Nucleoside thiab nucleotide chemistry

Ua raws li tusHeterocyclic puag chav tsevHauv synthesis ntawmC-nucleosidesthiabHloov RNA analogs, tshwj xeeb rau qhov twg ruaj khov tiv thaiv enzymatic cleavage yog xav tau.

4. Khoom cua organic anpistry

Lub Tsev ThaivRau kev tsim kho ntawm ntau cov complex fused heteroccles. Lub tshuab hluav taws xob nplua nuj fused triazine-pyrrrole system tuaj yeem raug them ntxiv mus ntxiv, ua haujlwm hloov kho.

Cov txiaj ntsig

1. Cov tshuaj-cuam tshuam hearer

Kev coj ua zoo sib xws rau biologically nquag purines, tso cai siv taumimicry ntawm ntuj nucleobases, tseem ceeb hauv cov tshuaj tua kab mob thiab anticancer sawv cev.

2. Ntau yam pheej siv

Lub xub ntiag ntawm ib tug exocyclicy amine thiab hluav taws xob-hluav taws xob nplhaib muaj hluav taws xob muaj ntauReactive ChawRau kev derivatization ntxiv thiab pab pawg kev hloov kho.

3. Muaj nqis tus nqi hauv kev kho mob tiv thaiv kab mob

Raws li ib tug paubRemdesivir Proveor, nws ua lub luag haujlwm nruab nrab hauv kev tsim cov tshuaj uas inhibitViral RNA-RESTENT RNA polymerases (RDRAP), tseem ceeb rau kab mob kis.

4. Ruaj khov thiab sib tw

Amenable rauloj-teev synthesisNrog tswj hwm ruaj khov nyob rau hauv tus qauv cia thiab cov tshuaj tiv thaiv, qhov tseem ceeb rau cov chaw tsim tshuaj lag luam.

Tag

Pyrrolo2,1-f1,2,4triazin-4-amine 丨 CAS 159326-68-8yog aCov Tswv Yim Nruab NrabNyob rau hauv synthesis ntawm cov antiviral niaj hnub xws li remdesivir. Nws fused nitrogen-nplua nuj hererocckas ua rau nws siv hauv kev tsimnucleoside analogs, RNA kho kho mob, thiabPurine Mimics, nrog cov ntawv thov dav hauvtxuj ci, oncology, thiabKev Siv Tshuaj Kho Mob TshuajCov. Nws qhov tseem ceeb yog hais tshwj xeeb hauv kev tsim tshuaj thiab kev tshawb pom tshuaj ua rau kis kab mob.