Methyl 1-Boc-Azetidine-3-Carboxylate Pare Cas Casat 610791-05-4

Cov ntawv thov ntawm methyl 1-boc-azetidine-3-carboxylate 丨 cas yog 610791-05-4

1. Tshuaj Nruab Nrab

Dav siv nyob rau hauv synthesis ntawmCov neeg sib tw yeeb tshuajthiabCov lwg me me molecules, tshwj xeeb yog cov uas muaj kev cuam tshuam me me, ntiv nplhaib ntiv nplhaib me me, txhim kho cov tshuaj papardorics.

Ua raws li ib tug ua ntej ua ntejAzetidine-based derivatives, uas tau pom ntau zuj zus hauv cov tshuaj tshiab chemistry rau lawv cov kev ruaj khov metabolic thiab hom phiaj tshwj xeeb.

2. Peptide & Amino Acid derivatives

Muaj nuj nqi raws li ativ thaiv amino acid analog, pab tau nyob rau hauvpeptidomimetic tsim.

Cov pab pawg BOC muab kev tiv thaiv ib ntus rau cov amine, tso cai xaiv kev hloov pauv ntawm lwm txoj haujlwm.

3. Organic synthesis tsev thaiv

Lub nplhaib sib txawv ntawm lub nplhaib Azetidine muaj cov cimReactivity thiab Formational Constraintions, ua rau nws muaj txiaj ntsig zoo scaffold nyob rau hauv schthetic.

Lub Methyl Ester Enableskev txha kaslossisAmide Bollation, pab tau rau cov conjugation nyob rau hauv loj molecule sib dhos.

4. Fragment-Raws Li Kev Tshawb Xyuas Tshuaj (FBDD)

Qhov sib xyaw ua ke loj me me, txhais cov duab geometry, thiab cov tshuaj zoo li yeeb tshuaj ua nws haum raws li ayam tawgHauv Fragons Fragment Siv RauTus qauv-raws li cov tshuaj tsim qauv.

Cov txiaj ntsig

✅ conformational rigidity

Plaub-tus tswv cuab azetidine ntiv nplhaibTus qauv nruj, uas tuaj yeem txhim khoBinding AffinitythiabrabELLIALSntawm bioactive molecules.

✅ cov khoom siv hluav taws xob yooj yim

Cov compound muaj ob pawg muaj txiaj ntsig:

Boc (Tert-Butoxycarbonyl): Yooj yim tshem tawm nyob rau hauv acidic mob kom ua rau lub amine.

Methyl Ester: Hloov pauv rau cov kua qaub lossis cov chaw nyob raws li cov kev xav tau hluavtaws xav tau.

‡ Tau txhim kho cov tshuaj zoo li cov khoom siv

Azetidine Scaffolds feem ntau txhim khoso, metabolic ruaj khov, thiabQhov ncauj BioavailabilityHauv cov tshuaj molecules.

✅ Tau sib haum nrog cov tshuaj Chemistry Workstas

BOC-tiv thaiv Azetidine derivatives yog cov intermediates tau tshaj nrogCaw Rho Tawm Hluav Taws XobthiabCombinatorial ChemistryCov tswv yim.

Lub ntsiab

Methyl 1-Boc-Azetidine-3-Carboxylate Pare Cas Casat 610791-05-4yog ib qho ntau yam nyob rau hauv cov tshuaj sapticaltical, tshwj xeeb tshaj yog nyob rau hauv kev txhim kho cov tshuaj zetidine thiab peptidomimetics. Nws kev sib xyaw ntawm boc-tiv thaiv amine thiab methyl ester muab cov qauv hluav taws xob zoo heev, thaum lub suab nrov nrov ntawm lub cev ua haujlwm kom xav tau cov khoom siv hluav taws xob thiab pharmacological thiab pharmacological thiab pharmacological.