Kev tsis

Hauj lwm lawm

Cov lus qhia tshwj xeeb ntawm Ezetimias 丨 {163222-33-1

Zog:	Dawb crystalline hmoov
Cov ntsiab lus:	98. {{0% ~ 1 {{}} 2.0% (suav rau ntawm cov tshuaj anhydrous)
Solubility:	Soluble hauv methanol lossis ethanol, soluble hauv acetoniturrile, yuav luag insoluble hauv dej lossis n-hexane
Melting taw tes:	161 ~ 166 degree
Cov ntsiab lus dej:	{{0 {}}. 6% Max
Kev sib hloov tshwj xeeb:	{{0 {}} degree ~ -29 degree
Daim qhia npe:	IR: spectrum yuav tsum concord nrog spectrum ntawm tus qauv; Kev tuav lub sijhawm ntawm cov qauv phim cov qauv hauv assay
Qhov siab tshaj plaws ib leeg:	{{0 {}}. 5% Max
Tag nrho cov impurities:	{{0 {}}. 9% Max
Impurity a:	0. 15% Max
Suav ntawm impurities C thiab D:	0. 15% Max
Impurity G:	{{0 {}}. 2% Max
Impurity F:	{{0 {}}. 10% Max
Unspecified impurity:	{{0 {}}. 10% Max
Tshaj tawm ntawm Achairal impurities:	{{0 {}}. 6% Max
Imived SSs:	{{0 {}}. 2% Max
Impurity RRR:	0. 1% Max
Ipurity E:	{{0 {}}. 4% Max
Impurity SSR:	{{0 {}}. 10% Max
Impurity RSR:	{{0 {}}. 10% Max
Suav ntawm chiral impurities:	{{0 {}}. 5% Max
4- Cov tshuaj Aluorine Aniline:	0. 15% Max
4- hydroxybenzaldehyde:	0. 15% Max
{{0 {0}} dimethylaminopyrdidine:	0. 15% Max
Isopropyl cawv:	{{0 {}}. 5% Max
Dichhloromethane:	{{0 {}}. 06% Max
Methyl tert-butyl ether:	{{0 {}}. 5% Max
N-hexane:	{{0 {}}. 029% Max
Ethyl acetate:	{{0 {}}. 5% Max
Methanol:	0. 3% Max
N, n-daimethylformamide:	0. 088% Max
Acetic acid:	{{0 {}}. 5% Max
Sulfate:	{{0 {}}. 04% Max
Cov hlau hnyav:	20 PPM Max
Fluorine:	8.2% - 9.3%

Cov ntaub ntawv thauj ntawm ezetimibe 丨 {163222-33-1

Chaw ua uas tsis tau haus	Kev qhia tshwj xeeb
UN NUM
Hom
Cov Pab Pawg
Hs code	2934999099305
Ruaj khov & rov ua	Ruaj khov nyob rau hauv cov neeg muaj kev cia.
Chaw ntim khoom	Nruj nreem kaw. Muab cia rau hauv qhov chaw kaw, qhuav, qhov chaw muaj zog. 0-8 degree
Mob kom tsis txhob
Lub thawv

Cov ntaub ntawv tsim khoom ntawm Ezetimias 丨 {163222-33-1

Chaw ua uas tsis tau haus	Kev qhia tshwj xeeb
Lub peev xwm	500mt \/ hli
Hov ntau
Lub teb chaws tseem ceeb
Peev Xwm \/ Batch
Paub lawm	Ntau lawm txij xyoo 2010
Ntxiv rau

Lub ntsiab

Ezetimibe {{163222-33-1 yog cov neeg sawv cev lipid-uas ua haujlwm los ntawm xaiv tau cov hnyuv rog. Nws yog feem ntau siv nyob rau hauv kev kho mob ntawm hypercholiaterolemia thiab lwm yam lipid kev tsis sib haum xeeb, txawm tias yog kev ua ke nrog statins.

Cov ntawv thov ntawmEzetimias 丨 163222-33-1

1. Kev kho mob ntawm hypercholesterolemia
● Feem ntau qhia tau rau thawj (heterozlygous hummial thiab nonfamilial) hypercholesterolemia.
● Siv cov roj lipoprotein tsawg dua (LDL-C) los ntawm 18-25% thaum siv ib leeg.
● Yuav siv tau ua ke nrog statins (piv txwv li, simvastatin, atorvastatin) rau txhim kho ldl-txo cov nyhuv (txog 50-60%).
2. Homozygous hyperchaolesterolemia (Hofh)
Siv ua ke nrog statins thiab lwm txoj kev kho lipid-uas txo qis hauv cov neeg mob hofh kom ua tiav cov phiaj roj cholesterol qib.
3. Homozygous Sitosterolememia (Phytosterolemia)
● Tsis tshua muaj kev cuam tshuam txog cov caj ces hauv cov nroj tsuag uas muaj cov nroj tsuag uas muaj ntau dhau.
● Ezetimibe txo cov ntshav pluas ntshav sterol los ntawm 35-45% los ntawm kev thaiv lawv cov kev nqus.
4. Feem Mob Kab Mob Kev Nyab Xeeb Kev Nyab Xeeb
● Thaum ntxiv rau Statin kev kho mob, ezetimibe ntxiv txo cov kev sim plawv plawv, raws li pom hauv cov kev sim tshuaj xyuas zoo li txhim kho-nws, tshwj xeeb hauv cov neeg mob sab nrauv.

Mechanism ntawm Kev Ua
Ezetimibe kev ua ntawm tus txhuam hniav ntawm cov hnyuv me me kom inhibit niement c {1}} Zoo li 1 (NPC1l1) protein, ib qho kev thauj mus los ntawm cov roj (cholesterol thiab cog qoob loo.
● Txo cov roj cholesterol uas tau xa mus rau daim siab.
● Ua kom peb coj los khi ntawm LDL cov receptors hauv daim siab, txhim kho kev tshem tawm LDL-C los ntawm cov ntshav.
Qhov tseem ceeb, ezetimias tsis muaj kev cuam tshuam rau Triglycerides lossis HDL cov roj cholesterol lossis HDL (cholesterolit cov tshuaj synthesis, ua rau muaj kev sib txuam rau cov neeg sib tw.

Cov txiaj ntsig ntawmEzetimias 丨 163222-33-1

1. LDL Cloterterol Txo
● Thaum statins tsis txaus los yog tsis zam, ezetimibe yog qhov tseem ceeb ntxiv-rau lossis lwm txoj hauv kev.
● Mus koom cov neeg mob LDL-C GARS, tshwj xeeb yog cov neeg nyob siab lossis muaj kev pheej hmoo siab heev.
2. Zoo zam thiab muaj cov kev mob tshwm sim
● Kev nqus cov txheej txheem tsawg kawg - feem ntau ntawm cov tshuaj ua nyob hauv zos hauv cov hnyuv.
● Cov kev mob tshwm sim feem ntau me me thiab infrequent, xws li raws plab, qaug zog, lossis mob plab.
● Kev pheej hmoo tsawg dua ntawm cov leeg ua kom muaj kuab lom piv rau cov statins, ua rau nws haum rau cov neeg mob uas muaj cov neeg mob statin.
3. Tsis muaj kev cuam tshuam rau daim siab enzymes lossis cov metabolose zoo li cas
Ers Tsis zoo li statins, ezetime 丨 {163222-33-1}} Tsis yuav ua rau daim siab ua kom tawv nqaij lossis ntshav qab zib.
● Kev xaiv nyab xeeb rau cov neeg mob ntshav qab zib lossis mob siab (nrog saib xyuas).
4. Kev muab tshuaj txhuam hniav yooj yim
● Ib zaug ib zaug ntsiav tshuaj txhua hnub (feem ntau 10 mg), nrog lossis tsis muaj zaub mov.
● Yuav ua tau yooj yim co-tswj hwm los yog co-formulated nrog statins (piv txwv li, ezetimibe + Simvastatin {3}} vytorin®}}} Vytorin®}} Vytorin®).

Kev tshawb fawb ntxiv thiab tawm ntawm kev siv
● Tau raug tshawb nrhiav hauv kev sib xyaw nrog PCSK9 inhibitors, bempedoic acid, thiab fibrates rau kev tswj txoj cai lipid.
● Kawm txog cov kev tuaj yeem tiv thaiv kev tiv thaiv thiab tiv thaiv cov teeb meem Atherosclerotic tshaj li LDL-C This.

Tag
Ezetimibe {{163222-33-1 yog ib tug zoo-tsim cov khoom nqus dej hauv kev tswj hyperlipidemia, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas yuav tsum tau ntxiv rau statins. Nrog kev ua haujlwm tsawg heev, thiab cov txiaj ntsig kev nyab xeeb muaj txiaj ntsig hauv atherosclerotion cardioveasent yog qhov tseem ceeb ntawm cov tswv yim lipid niaj hnub.

Cim npe nrov: Ezetimibe 丨 cas 163222-33-1}, Tuam Tshoj Ezetimste 163222-33-1 Cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas