Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov kws tshaj lij thiab cov neeg muag khoom ntawm abiraterone acetate 丨cas 154229-18-2 hauv Suav teb. Txais tos rau kev lag luam wholesale kev cai ua cov khoom lag luam ntawm tus nqi sib tw los ntawm peb lub hoobkas. Rau cov khoom pheej yig dua, tiv tauj peb tam sim no.
Specifications
| Qib | USP 2024 |
| Qhov tshwm sim | Dawb los yog tawm -dawb hmoov |
| Assay (raws li -yog lub hauv paus) | 98.0–102.0% |
| Solubility | Yuav tsum ua raws li cov cai |
| Kev txheeb xyuas (IR) | IR absorption spectrum ntawm tus qauv yuav tsum ua raws li tus qauv siv |
| Kev txheeb xyuas (HPLC) | Lub sijhawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau hauv chromatogram ntawm cov qauv kev daws teeb meem |
| Dej | 0.25% max |
| Residue ntawm ignition | 0.1% max |
| -Epoxyabiraterone acetate | 0.25% max |
| -Epoxyabiraterone acetate | 0.25% max |
| Abiraterone | 0.20% max |
| Abiraterone ethyl ether | 0.20% max |
| Abiraterone isopropyl ether | 0.20% max |
| Unspecified impurities | 0.10% max |
| Tag nrho impurities | 0.80% max |
Daim ntawv thov
Abiraterone acetate (CAS 154229-18-}2) yog ib qho steroidal compound siv feem ntau hauv kev tshawb fawb tshuaj thiab kev kho mob ntsig txog cov tshuaj hormone-dependent. Nws ua haujlwm raws li cov tshuaj uas hloov pauv hauv vivo rau abiraterone, inhibitor ntawm CYP17 (17 -hydroxylase/C17,20-lyase), ib qho tseem ceeb enzyme koom nrog hauv androgen biosynthesis. Yog li ntawd, nws yog dav siv nyob rau hauv txoj kev tshawb no, kev loj hlob, thiab tsim cov kev kho mob tsom cov kab mob androgen-tsav, tshwj xeeb tshaj yog mob qog noj ntshav prostate. Abiraterone acetate kuj tseem siv hauv kev tshawb fawb tshuaj los tshawb xyuas cov tshuaj steroid metabolism, androgen signaling pathways, thiab endocrine tswj. Tsis tas li ntawd, nws ua haujlwm raws li tus qauv siv thiab cov khoom siv tshuaj nquag (API) hauv kev tsim kho, kev tswj kom zoo, thiab kev tshawb fawb txog kev tswj hwm hauv kev lag luam kws tshuaj.
Cov txiaj ntsig
Cov txiaj ntsig ntawm abiraterone acetate tshwm sim los ntawm nws lub hom phiaj ntawm kev ua haujlwm, muaj txiaj ntsig zoo bioavailability raws li cov tshuaj, thiab zoo -txhais cov qauv steroidal. Los ntawm kev xaiv inhibiting androgen biosynthesis ntawm ntau qhov chaw, nws ua rau muaj txiaj ntsig zoo ntawm androgen ntau dua li cov qauv siv. Cov acetate ester txhim kho qhov ncauj nqus thiab kev ua haujlwm pharmacokinetic piv nrog cov metabolite nquag ua haujlwm ib leeg. Nws qhov tshwj xeeb tshwj xeeb rau CYP17 txhawb kev kwv yees tus cwj pwm pharmacological, thaum nws cov tshuaj lom neeg ruaj khov tso cai txhim khu kev qha tsim thiab khaws cia. Cov cwj pwm no ua rau abiraterone acetate muaj zog thiab muaj txiaj ntsig zoo rau kev siv tshuaj kho mob, kev txhim kho tshuaj, thiab kev tshawb fawb txog endocrine.
Xaus
Abiraterone acetate yog ib qho tseem ceeb steroidal tshuaj compound nrog zoo -tsim daim ntawv thov nyob rau hauv androgen-txoj kev kho thiab kev tshawb fawb endocrine. Nws cov qauv tsim prodrug, tsom enzyme inhibition, thiab cov khoom siv tshuaj muaj txiaj ntsig zoo txhawb nqa cov tswv yim kho mob zoo thiab txhim kho cov tshuaj txhim khu kev qha. Los ntawm kev ua kom muaj kev tswj hwm ntawm androgen biosynthesis, abiraterone acetate tseem ua lub luag haujlwm tseem ceeb hauv kev tshawb fawb tshuaj niaj hnub thiab kev kho mob.
Cim npe nrov: Tuam Tshoj abiraterone acetate cas 154229-18-2 manufacturers, lwm tus neeg, Hoobkas
