Cov lus qhia
| Kev tshwm sim | Cov khoom daj |
| Kev coj dawb huv | 95% min |
Cov Ntawv Thov
6 {- (difluvretomethyl)-3-amine (CAST) Nws pyridine cov tub ntxhais, hloov nrog nrog difluoromethyl, me me pawg neeg thaiv, enzyme modulators, thiab kev kho kom zoo dua qub. Hauv kev ua tshuaj chemistry, nws tau ua haujlwm los qhia cov tshuaj fluorinated uas txhim kho kev ruaj khov, los ntawm kev sib tw sib txawv, thiab Lipophilicity hauv cov neeg sib tw tshuaj. Nyob rau hauv agochemical kev tshawb fawb, nws ua haujlwm ua ib qho tseem ceeb rau cov tshuaj tua kab, cov fungicides, thiab tshuaj tua kab, muab cov tshuaj tua kab mob ib puag ncig, ib puag ncig. Ib qho ntxiv, nws yog siv rau kev tshawb fawb tshuaj zoo los tsim cov fluorinated herornyclicclics Scaffolds rau cov qauv-kev sib raug zoo (SAR) kev kawm.
Cov txiaj ntsig
Cov txiaj ntsig ntawm 6- (Difluoromethyl) -5-amine qia los ntawm nws multifunctional reactivity thiab fluorinated qauv. Cov amino pab pawg ua rau muaj kev xaiv los ntawm kev ua yeeb yam, alkylation, lossis txhim kho membrane permeability hauv cov tebchaw bioaction. Lub nplhaib pyridine muab cov pob tw tawv, cov phiaj xwm scaffle haum rau kev khi cov hom phiaj hauv roj ntsha thiab lipophilic uas tuaj yeem ua kom zoo ua haujlwm pharmacokinetics. Ua ke, cov nta no ua rau nws muaj txiaj ntsig zoo rau kev tsim cov lwg me me nrog kev siv tau ntau, xaiv cov khoom siv tshuaj lom neeg.
Tag
Hauv cov ntsiab lus, 6 - (difluoromethyl)-}}} Yog ib qho kev tshawb fawb tseem ceeb hauv chaw muag tshuaj thiab agnemical kev tshawb fawb. Nws cov kev siv suav nrog cov lus qhia ntawm Kinease inibitors, thiab cov txiaj ntsig kev tiv thaiv, thiab cov khoom siv tshuaj lom neeg ruaj khov, thiab scaffold rigidity. Raws li kev thov rau fluorinated heterocycles hauv tshuaj nrhiav pom thiab agnochemicals, qhov sib xyaw no tseem ceeb heev rau kev txhim kho lub zog thiab ruaj khov cov molecules.
Cim npe nrov: 6- (Difluoromethyl)-3-amine 丨 Cas 1806766-7-Methylpretin-3-amine 丨 Cas 1806 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj
