6-bromoimidazo [1,2-a] pyridin-8-amine 丨 cas yog 676371-00-9

1. Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab Kev Loj Hlob

Siv los ua lub tsev thaiv hauv cov synthesis ntawm tshiab bioactive molecules.

Lub Imidazo [1,2-a] pyridine scaffold yog paub rau nws muaj nyob hauv ntau cov tshuaj nrog cov khoom siv hluav taws xob nrog rau:

Tshuaj ntxuav

Tus tua kab

Tshuaj tiv thaiv

CNS (Central hlwb) cov neeg sawv cev

Lub bromine athgets rau kev sib tshuam hla (piv txwv li, Suzuki, Heck, Sonogashira), yooj yim rau cov lus qhia ntawm ntau yam kev ua haujlwm.

Cov pab pawg AMine muaj lub xaib rau kev ua haujlwm ntxiv lossis kev sib txuas.

2. Tshuaj Kho Mob Chemistry

Ua kom tus qauv tsim thiab hluavtaws ntawm cov sib txuas lus sib txuas lus Kinases, txais, thiab cov enzymes.

Siv nyob rau hauv cov taug txhuas optimization kom txhim kho ntau, xaiv, thiab cov khoom siv pharmaci.

3. Tshuaj lom neeg biology

Ua haujlwm ua ib qho cuab yeej ua ke lossis nruab nrab hauv cov tshuaj nrhiav kev txhim kho tshuaj lom neeg.

Tuaj yeem tso rau hauv cov tsev qiv ntawv rau kev kuaj xyuas cov hom phiaj roj ntsha.

✅ Verstatile synthetic nruab nrab

Lub xub ntiag ntawm bromine ntawm 6-txoj hauj lwm muab cov tshuaj kho kom haum rau palladium-catalyzed hla-txuas cov kev sib tshuam.

Lub amine ntawm txoj hauj lwm 8 tso cai rau kev ua haujlwm ntawm acylation, alkylation, lossis lwm yam kev hloov kho.

✅ Chaw muag tshuaj cuam tshuam scaffold

Imidazo [1,2-a] pyridines paub txog lawv cov tshuaj zoo li cov tshuaj xws li cov khoom lag luam zoo thiab kev ruaj khov metabolility.

Cov scaffold yog muaj cai hauv cov tshuaj chemistry, txhais tau tias nws nquag ua rau muaj kev sib txuas ua ke lom zem.

✅ Pab tswj cov teeb meem-kev ua haujlwm sib raug zoo (SAR) kev tshawb fawb

Tso cai rau cov kws kho mob tshuaj rau cov neeg hloov pauv hloov pauv rau qhov ua tau zoo thiab txo qis kev lom zem.