5-azaindole Peb Cas Cas 271-34-1

1. Tshuaj Kho Mob Chemistry

5-azaindole tau siv dav ua qhov tsim nyog scaffold hauv kev tshuaj pom kev noj tshuaj vim nws lub bioisosterism nrog indole thiab pyridine. Nws plays lub luag haujlwm tseem ceeb hauv:

Kinase inhibitors: ua los ua pob khawm-khi nyob rau hauv ATP-kev sib tw Inhibitors rau Kinases zoo li JAK, BTK, thiab Braf.

Anticancer cov neeg sawv cev: koom rau hauv cov lwg me me tsom rau cov protein force.

Cov tshuaj tiv thaiv kab mob: siv nyob rau hauv cov sib xyaw ua ke ntawm inhibit rau kis tus kab mob replal txoj kev.

Los tiv thaiv cov neeg sawv cev: pom nyob rau hauv cov neeg sib tw tshuaj uas hloov kho cov kab mob.

Piv txwv:

Pom hauv jak inibitors (piv txwv li, filgotinib analogs)

Cov qauv tseem ceeb hauv qee cov Tyrosine Kinase inibitors thiab cdk inhibitors

2. Fragment-Raws Li Kev Tsim Tshuaj (FBDD)

Vim nws qhov loj me, teeb meem, thiab dej siab havy hydrogen cuab pob zeb, 5-azaindole yog ib qho tseem ceeb ua rau muaj cov molecules tseem ceeb.

3. Heterocanclic Tsev Thaiv

Siv los ua cov khoom siv pib lossis nruab nrab hauv synthesis ntawm:

Cov neeg sib tw harterocyclic tshuaj

Bioactive Agochnicals

Cov ntaub ntawv muaj nuj nqi rau cov khoom siv hluav taws xob organic

4. Fluorescent Probes & Ligands

Vim nws cov ntxhiab tsw thiab kev pub dawb-pub dawb atoms, derivatives ntawm 5-azaindole tau tshawb hauv:

Fluorescent Sensors

Molecular lees paub kev kawm

Kev sib koom tes thiab kev ua haujlwm chemistry

✅ Bioisosteric Versatility

Ua hauj lwm ua bioisostere rau kev qhia thiab purine Moidies, ua kom zoo-tu ntawm cov kws muag tshuaj thiab cov tshuaj pharpacodynamic profiles.

Hloov kho h-daim ntawv pub dawb / cov qauv lees txais los txhim kho cov tshuaj-receptor binding.

✅ Txhim kho solubility thiab metabolic ruaj khov

Piv rau indole, 5-azaindole feem ntau imparts zoo aqueous solubility thiab metabolic tsis kam rau cov neeg sib tw ua yeeb ncuab.

✅ synthictic siv tau

Npaj tau yooj yim muaj kev lag luam thiab zoo rau kev ua haujlwm sib txawv (piv txwv li, halogenation, alkination, txhawb nqa cov khoom siv sai sai.

✅ Fridment efficiency

Siab light ligand efficiency thiab cov mw, qis mw, siab polf thaj tsam thaj tsam) ua rau nws zoo tagnrho hauv kev tsim tshuaj yeeb tshuaj thaum ntxov.

✅ Txhim Kho Cov Kev Sib Tham Tau

Qhov ntxiv nitrogen txhim kho π-stacking π-hydrogen kev sib koom tes, thiab kev sib koom tes hlau - txhua qhov tseem ceeb hauv kev sib tw macromolecules.