(3S,4S) -3-Amino-4-hydroxy-tetrahydropyran CAS 1240390-32-2

(3S,4S)-3-Amino-4-hydroxy-tetrahydropyran feem ntau yog siv los ua chiral tsev thaiv hauv kev tshuaj thiab tshuaj lom neeg zoo. Nws lub nplhaib stereochemically txhais tetrahydropyran ua rau nws muaj txiaj ntsig zoo rau kev tsim cov molecules complex, tshwj xeeb tshaj yog cov uas yuav tsum tau qhov tseeb peb-dimensional orientation rau lom lom. Lub compound yog siv nyob rau hauv lub synthesis ntawm active tshuaj cov khoom xyaw, intermediates, thiab analogs qhov twg heterocyclic moj khaum thiab ntau functional pab pawg neeg yog qhov tseem ceeb. Hauv cov chaw tshawb fawb, nws yog siv los tshawb nrhiav cov qauv-kev sib raug zoo, tsim cov txheej txheem hluavtaws stereoselective, thiab tsim cov molecules nrog txhim kho kev sib raug zoo thiab kev xaiv. Nws kuj tseem ua haujlwm hauv cov kev pabcuam tshuaj chemistry tsom rau carbohydrate mimetics thiab bioisosteric hloov.

Lub compound muaj ntau yam zoo vim nws cov stereochemistry thiab multifunctional xwm. Lub xub ntiag ntawm ob pawg amino thiab hydroxyl ua rau muaj ntau yam tshuaj hloov pauv, suav nrog acylation, alkylation, thiab cyclization, txhawb cov tswv yim sib xyaw ua ke. Nws cov tawv tsis tau ua haujlwm tetrahydropyran scaffold txhim kho kev tswj hwm ntawm molecular conformation, uas yog ib qho tseem ceeb hauv kev tsim tshuaj thiab kev ntsuam xyuas lom. Lub stereochemical purity ntawm lub compound ua kom paub tseeb tias muaj kev cuam tshuam thiab kev ua haujlwm zoo ib yam hauv kev sib txuas, txo qhov xav tau rau kev daws teeb meem ntxiv. Tsis tas li ntawd, nws txoj kev sib raug zoo nrog cov txheej txheem cov kuab tshuaj organic thiab cov tshuaj tiv thaiv kab mob ua rau muaj txiaj ntsig zoo hauv kev sim thiab kev loj hlob ib puag ncig.