Cov lus qhia
| Zog: | Off-dawb lossis lub teeb liab |
| Purity (GC): | 98% min |
| Purity (HPLC): | 99% min |
| Hnmr: | Tshaj tawm cov qauv |
Cov Ntawv Thov
1. Tshuaj Nruab Nrab
Siv los ua lub tsev chairal thaiv rau cov synthesis ntawm enantiomerically ntshiab tshuaj.
Fluorine atom thiab sterochemistry cuam tshuam kev ua haujlwm, kev ruaj khov metabolic, thiab lipophilicity ntawm cov neeg sib tw ntawm cov tshuaj.
Qhov tseem ceeb hauv kev tsim cov tshuaj ua rau muaj lub paj hlwb nruab nrab (CNS), tshuaj tua kab mob, thiab tiv thaiv cov neeg sawv cev.
2. Tshuaj Kho Mob Chemistry
Tseem ceeb rau kev tsim qauv-kev sib raug zoo (SAR) kev tshawb fawb muaj feem nrog fluorinated fluorinycles.
Ua rau kev tshawb nrhiav cov tshuaj fluorine cuam tshuam rau kev ua tshuaj ua tshuaj thiab tuav ntaub qhwv.
3. Fluorinated sib xyaw synthesis
Ua hauj lwm ua tus thawj coj ua ntej rau synthesizing fluorinated analogs ntawm cov khoom ntuj thiab cov lwg me me.
Txhawb kev txhim kho ntawm cov neeg tshiab fluorinated nigands thiab catalysts.
Cov txiaj ntsig
Chairality thiab Purity: muab kev nkag mus rau ib leeg enantiomer tebchaw, tseem ceeb rau kev ua tau tshuaj thiab kev nyab xeeb.
Txhim kho cov tshuaj yeeb yaj kiab: Fluorine hloov chaw feem ntau txhim kho kev ruaj khov metabolic, membrane permeability, thiab khi affinity.
Versatile intermediate: Pab tau nyob rau ntau yam kev hloov tshuaj lom vim nws pawg ua haujlwm thiab kev sib koom tes.
DEJ SOLLEGLE: Kev qhia kev yooj yim yooj yim ntawm kev tuav thiab tsim nyob rau hauv aqueous ib puag ncig.
Tag
(3s) - (+) - 3-fluoroprolidine hydrochloride (CAS 13725-53 Nws cov kev txhawb nqa thiab cov tshuaj fluorine hloov kho cov khoom siv tshuaj-zoo li tshuaj, ua rau nws muaj txiaj ntsig zoo rau kev tsim kho tshiab. Cov compound cov versatility thiab enantiomer purity txuas ntxiv mus rau tsav nws qhov tseem ceeb hauv kev tshawb tshuaj yeeb thiab kev loj hlob.
Cim npe nrov: (3s) - (+) - 3-fluoroprolidine hydrochloride 丨 CAS 136725-53 - 3. +) - (3s) - (3,6 tuam txhab
