2-Bromo-6-methoxynaphthalene CAS 5111-65-9

1. Synthetic Intermediate hauv Organic Chemistry

Vim tias muaj ob qho tib si reactive bromine atom thiab ib qho hluav taws xob - pub dawb methoxy pab pawg, 2-Bromo-6-methoxynaphthalene yog ib qho kev sib txawv nruab nrab hauv ntau yam kev cuam tshuam cov organic:

Hla -Cov lus sib txuas:

Siv nyob rau hauv Suzuki, Stille, Sonogashira, thiab Heck coupling kev cuam tshuam los tsim complex biaryl los yog aryl-alkyne systems.

Ua kom yooj yim rau kev tsim cov ntawv cog lus C-C, tshwj xeeb tshaj yog rau cov tshuaj -zoo li molecules thiab natural product analogs.

Lithiation thiab Nucleophilic Hloov:

Cov bromine tuaj yeem hloov tau los ntawm hlau-halogen pauv (xws li, siv n-BuLi), ua raws li electrophilic ntxiab.

O-Demethylation:

Cov pab pawg methoxy tuaj yeem xaiv tau hloov pauv (xws li hloov mus rau hydroxyl), muab kev nkag mus rau hydroxynaphthalene derivatives.

2. Pharmaceutical and Medicinal Chemistry

2-Bromo-6-methoxynaphthalene yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm biologically active compounds:

Aromatic pharmacophores: Naphthalene derivatives muaj nyob rau hauv kws tshuaj vim lawv cov qauv aromatic thiab bioactivity.

Lead compound development: Siv nyob rau hauv thaum ntxov- tshawb nrhiav tshuaj yeeb tshuaj los tsim cov tshuaj analogues tshiab ntawm cov tshuaj tua kab mob, tshuaj tua kab mob, lossis tshuaj tiv thaiv - cov tshuaj tiv thaiv kab mob.

3. Fluorescent Dye thiab Khoom Synthesis

Methoxynaphthalene-raws li cov tebchaw yog qee zaum siv hauv kev tsim:

Organic teeb -emitting diodes (OLEDs)

Fluorescent dyes los yog sensors

Photostable aromatic cores nyob rau hauv cov ntaub ntawv siab heev thiab polymers

Brominated derivatives zoo li qhov no yog qhov zoo tshaj plaws rau kev ua haujlwm ntxiv, ua kom zoo - kho qhov molecule qhov kho qhov muag lossis hluav taws xob.

4. Agrochemical Intermediates

Nws kuj tseem tuaj yeem siv rau hauv kev sib xyaw ntawm cov tshuaj tua kab, tshuaj tua kab, lossis cov tshuaj tua kab mob, tshwj xeeb tshaj yog cov uas ua raws li fused aromatic nplhaib systems nrog halogen / methoxy functionality.

1. Dual Functional Groups rau Versatile Reactivity

Cov bromine atom tso cai rau palladium{0}}catalyzed cross-coupling, thaum pawg methoxy tuaj yeem koom nrog hauv kev kho hluav taws xob, hloov pauv, lossis demethylation.

2. Siv Scaffold rau Kev Txhim Kho Tshuaj

Cov tub ntxhais naphthalene feem ntau pom muaj nyob rau hauv cov tshuaj chemistry vim nws cov qauv muaj ntxhiab tsw thiab cov cwj pwm hydrophobic- ua rau nws muaj txiaj ntsig zoo hauv tsev.

3. ruaj khov thiab yooj yim los tuav

Khoom nyob rau hauv chav tsev kub, nrog zoo txee stability nyob rau hauv zoo cia tej yam kev mob.

Haum rau qhov ntsuas - nce hauv kev lag luam lossis kev tshawb fawb.

4. Ua kom muaj kev sib txawv ntawm cov qauv

Tso cai rau cov kws kho mob thiab cov kws tshawb fawb txog cov khoom siv los tsim cov tsev qiv ntawv sib txawv ntawm kev lig -theem functionalization.