Specifications
| Qib | Qib EP; qib txhaj tshuaj |
| Qhov tshwm sim | Dawb los yog yuav luag dawb, waxy hmoov, microbeads los yog flakes |
| Solubility | Soluble hauv dej thiab hauv ethanol (96%) |
| Melting point | Txog 50 degree |
| Kev Taw Qhia A | Infrared nqus spectrophotometer |
| Kev Qhia B | Qhov nruab nrab txheeb ze molecular loj |
| Qhov tshwm sim ntawm kev daws teeb meem | Kev daws S tsis yog xim xim ntau dua li kev siv tshuaj BY7 |
| pH | 5.0 – 7.5 |
| Ethylene oxide | 1 ppm max |
| Propylene oxide | 5 ppm max |
| Dioxane | 10 ppm max |
| Qhov nruab nrab txheeb ze molecular loj | 7680 – 9510 |
| Oxyethylene ratio | 79.9 – 83.7% |
| Dej | 1.0% max |
| Tag nrho cov tshauv | 0.4% max |
| Cov hlau hnyav | 20 ppm max |
| Kev kuaj kab mob endotoxin | 10 EU / g max |
| Cov kab mob microbial | Tag nrho aerobic microbial suav Tsawg dua lossis sib npaug li 50 cfu / g; tag nrho cov pwm ua ke thiab cov poov xab Tsawg dua lossis sib npaug li 10 cfu / g; Tsis muaj Salmonella, E. coli, P. aeruginosa, S. aureus, thiab Enterobacteriaceae resistant rau cov kua tsib |
Daim ntawv thov
Poloxamer 188 yog ib qho nonionic triblock copolymer muaj li ntawm polyethylene oxide thiab polypropylene oxide ntu, dav siv hauv tshuaj, biomedical, tshuaj pleev ib ce, thiab kev lag luam formulations. Hauv kev siv tshuaj, nws ua haujlwm raws li surfactant, solubilizer, thiab stabilizer hauv cov tshuaj txhaj tshuaj, cov kua hauv qhov ncauj, thiab cov khoom siv tshuaj pleev ib ce los txhim kho cov solubility thiab bioavailability ntawm cov dej tsis zoo - cov tshuaj soluble. Poloxamer 188 kuj tseem siv rau hauv kab lis kev cai ntawm tes, kev xa cov noob, thiab tsim cov protein kom tiv thaiv cov cell thiab biomolecules los ntawm kev ntxhov siab thiab kev sib sau. Hauv kev tshawb fawb biomedical, nws tau kawm txog nws daim nyias nyias- cov khoom sib khi thiab siv rau hauv kev tshawb nrhiav ntsig txog ischemia- rov ua kom raug mob thiab tiv thaiv cov leeg lossis paj hlwb. Tsis tas li ntawd, cov khoom siv yog siv rau hauv cov tshuaj pleev ib ce thiab cov khoom tu tus kheej ua cov emulsifier thiab cov tshuaj ntxuav me me, nrog rau cov ntawv thov kev lag luam uas yuav tsum tau tswj cov ntub dej thiab tawg.
Cov txiaj ntsig
Poloxamer 188 muaj ntau qhov zoo vim nws cov biocompatibility zoo heev, tsis muaj tshuaj lom, thiab kev ua haujlwm ntau. Nws cov xwm txheej nonionic muab kev ruaj ntseg ntawm ntau yam pH thiab kev sib raug zoo nrog ntau yam khoom xyaw thiab excipients. Lub compound zoo txo qhov nro thiab interfacial nro, txhim kho solubilization thiab formulation stability. Poloxamer 188 yog dej-soluble, tshuaj lom neeg ruaj khov, thiab tiv taus cov enzymatic degradation, ua rau nws tsim nyog rau kev siv tshuaj lom neeg thiab tshuaj. Nws lub peev xwm los tiv thaiv cell membranes thiab proteins nyob rau hauv kev ntxhov siab ntxiv txhim kho nws cov nqi hauv biomedical thiab kev tshawb fawb chaw.
Xaus
Poloxamer 188 yog ntau yam thiab dav siv polymer nrog cov ntaub ntawv tseem ceeb hauv kev siv tshuaj, kev tshawb fawb biomedical, tshuaj pleev ib ce, thiab cov qauv tsim. Nws cov txiaj ntsig, suav nrog biocompatibility, muaj peev xwm solubilization, kev ruaj ntseg tsim, thiab kev tiv thaiv los ntawm cov hlwb thiab biomolecules, ua rau nws yog ib qho tseem ceeb excipient thiab cov ntaub ntawv tshawb fawb. Cov tshuaj txuas ntxiv txhawb kev nce qib hauv kev xa tshuaj, kev txhim kho kev kho mob, thiab siab -kev tsim qauv tsim.
Cim npe nrov: Poloxamer 188丨cas 9003-11-6, Tuam Tshoj poloxamer 188丨cas 9003-11-6 manufacturers, lwm tus neeg, Hoobkas
