Cov lus qhia
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Kev tshwm sim |
Dawb khoom |
|
Kev coj dawb huv |
99% min |
|
Daim qhia npe |
IR, HPLC |
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Polymorph |
Ua a |
|
Ywg dej |
{{0 {}}. 5% Max |
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Kev Sib Hloov Tshwj Xeeb |
{{{{0}} degree rau -45 mg \/ ml, methanol) |
|
Microbial txwv - Tamc |
30 cfu \/ g max |
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Microbial Txwv - Tymc |
10 cfu \/ g max |
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Ib Leeg Cav |
{{0 {}}. 2% Max |
|
Tag nrho cov impurities |
1. {0 max |
Cov Ntaub Ntawv Thauj
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Chaw ua uas tsis tau haus |
Kev qhia tshwj xeeb |
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UN NUM |
|
|
Hom |
|
|
Cov Pab Pawg |
|
|
Hs code |
2934999099305 |
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Ruaj khov & rov ua |
Cov khoom lag luam ruaj khov nyob rau hauv cov qauv ambient ambient. |
|
Chaw ntim khoom |
Kaw cov thawv kom nruj kom kaw hauv qhov chaw qhuav thiab zoo-ventilated. Pom zoo cia ntsuas kub: -20 degree |
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Mob kom tsis txhob |
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Lub thawv |
Cov ntaub ntawv raug
|
Chaw ua uas tsis tau haus |
Kev qhia tshwj xeeb |
|
Lub peev xwm |
1MT \/ XYOO |
|
Hov ntau |
|
|
Lub teb chaws tseem ceeb |
|
|
Peev Xwm \/ Batch |
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|
Paub lawm |
Ntau lawm txij li 2022 |
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Ntxiv rau |
Lub hauv paus rau phau ntawv
Mavacamten 丨 cas 1642288-47-8, yog thawj-hauv-chav kawm, kev xaiv cov cheeb tsam tsim rau kev kho mob ntawm hypertrophic cardiomyopathy (HCM). Nws sawv cev rau kev sib tawg hauv cov phiaj xwm kab mob ncaj qha los ntawm HCM, tus mob uas ua rau lub siab tsis zoo ntawm cov leeg lub plawv, tshwj xeeb yog sab laug ventricle. Mavacamen tau pom zoo los ntawm Asmeskas FDA hauv qab lub npe npe Camzyos.
Cov Ntawv Thov
A. Thaiv Hypertrophic Cardiomyopathy (Ohcm)
Daim thawj pom zoo tau pom zoo rau Mavacamten yog cov tsos mob sib piv ntawm hypertrophic cardiomyopathy (Ohcm).
Hauv cov neeg mob muaj Ohcm, mavastriously txo cov qhab nia lvot, txhim kho kev tawm dag zog xws li dyspnea mob, mob hauv siab, thiab qaug zog.
Pom zoo rau kev siv nyob rau hauv cov neeg laus NHA chav kawm II-III nrog cuam tshuam HCM.
B. Tsis yog-cuam tshuam HCM thiab lwm yam kev mob plawv (kev tshawb nrhiav)
Mavacamten kuj tseem tab tom tshawb nrhiav rau:
Tsis-obstructive HCM: ib qho ntawm cov neeg mob uas tuab tuab tsis muaj outflow ib qho kev sib txuas.
Lub plawv tsis ua hauj lwm nrog khaws cia feem kev tawm tsam (HFPEF): cov nqi hluav taws xob tsis muaj peev xwm txhim kho cov kev ua haujlwm diastolic.
Diastolic tuag nrog lwm daim cardiomyopathies.
Cov txiaj ntsig
A. Tus kab mob-kho txoj kev kho mob
Tsis zoo li kev kho HCM uas muaj cov tsos mob uas muaj cov tsos mob, Mavacamten?
Muaj peev xwm ua kom qeeb lossis rov qab muaj tus kab mob, tshwj xeeb yog thaum siv thaum ntxov.
B. Kev txhim kho hauv tsev kho mob tshwm sim
Hauv cov chaw kuaj mob sib tw (piv txwv li, Explorer-HCM), mavacmamt thiaj li hloov kho:
Kev thev taus kev ua haujlwm (Vo₂ Max)
NYHA FUNCTIONAL HOOB KAWM
Kev ua tau zoo ntawm lub neej (KCCQ, MLWHFQ)
Txo cov kev xav tau rau kev ua kom cov txheej txheem tsis zoo xws li phais cov tshuaj ectomy lossis dej cawv sinelation.
C. Kev Tswj Xyuas Qhov Ncauj
Muab cov ncauj lus ib zaug ib zaug, muab kev yooj yim siv piv rau kev cuam tshuam kev cuam tshuam lossis cov tshuaj tiv thaiv kev nyuaj.
D. R thim rov qab
Qhov cuam tshuam ntawm Mavacamten yog tshuaj pleev-nyob thiab thim rov qab, tso cai rau kev ceev faj lub kaum thiab saib xyuas raws li Echocardiogriographic thiab cov lus teb kho mob.
Tag
Mavacamten 丨 cas no 1642288-47-8 yog ib qho tshiab, xaiv lub plawv uas inhiboritor uas nyob hauv qab ntawm kev cuam tshuam hypertrophic cardiomyopathy. Nws lub peev xwm los txo cov myocardial hypercontractility, txhim kho kev ua haujlwm zoo, thiab muaj feem hloov tus kab mob nws yog qhov kev kho kho hauv plawv. Thaum ua tib zoo saib xyuas yog qhov tseem ceeb vim nws lub zog tsis zoo hauv kev saib xyuas mob HCM thiab tuav cov ntawv thov hauv yav tom ntej rau cov kev xaiv hauv yav tom ntej.
Cim npe nrov: mavacamten 丨 cas no 1642288-47-8} mavacamten 丨 cas 1642288-47-8 cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas
