Cov lus qhia
| Qib: | Ep 9 |
| Zog: | Ib tug dawb lossis yuav luag dawb crystalline hmoov |
| Assisy (hplc): | 98% rau 102% |
| Solubility: | Kev siv Insoluble hauv dej, sparingly soluble hauv methylene chloride, soluble me ntsis hauv ethanol (96%) thiab hauv methanil |
| Daim qhia npe: | Ir; HPLC conforms |
| Poob rau ziab: | 1.0% max |
| Residue ntawm ignition: | 0.5% max |
| Yam khoom: | |
| Impurity a: | 1.5% Max |
| Impurity C: | 0.5% max |
| Lwm yam impurity: | 0.5% max |
| Tag nrho cov impurities: | 2% Max |
Cov Ntawv Thov
1Cov. Kev Kho Mob Hom 2 Ntshav Qab Zib Mellitus (T2Dm)
Glyburide yog dav siv los tswj cov ntshav ntshav qab zib hauv cov neeg laus uas muaj cov ntshav qab zib hom 2, tshwj xeeb yog ib qho kev tawm dag zog, thiab ib leeg hnyav ib leeg tsis muaj txaus.
Kev tso cai: Siv nyob ib leeg los txhawb cov insulin zais ntawm cov txiav.
Kev Kho Mob: Feem ntau ua ke nrog lwm cov ntsaum Antidiabetic cov neeg sawv cev zoo li Metformin, DPP-4 inhibitors, lossis insulin kom ua tiav glycemic tswj.
2. Cov ntawv sau npe tawm
Txawm hais tias tsis yog ib txwm pom zoo, Glyburide tau kawm rau lwm cov kev siv:
Cov ntshav qab zib zoo me me (GDM): qee zaum siv daim ntawv lo ua rau cov tshuaj insulin rau hauv kev tswj cov ntshav ntshav hauv kev cev xeeb tub. Txawm li cas los xij, qhov kev siv no sib cav sib ceg vim muaj kev txhawj xeeb txog kev txhawj xeeb fetal raug.
Neonatal Diabetes: In very rare genetic forms of diabetes in newborns (eg, KATP channel mutations), glyburide may be used in specific clinical settings.
Cov txiaj ntsig
1. Kev tswj hwm Glycemic zoo
Glyburide tseem ceeb txo ob qho tib si kev yoo mov thiab kev ncua cov ntshav ntshav qab zib.
Pab txo hba1c (glycated hemoglobin), uas qhia txog kev tswj lub sijhawm glycemic ntev.
2. Ib zaug lossis ob zaug-txhua hnub noj tshuaj
Vim nws lub neej ntev-lub neej thiab muaj lub zog muaj txiaj ntsig, Glyburide yuav tau txais ib zaug lossis ob zaug ib hnub, txhim kho tus neeg mob ua kom muaj ntau yam koob tshuaj.
3. Nqi siv tau
Glyburide muaj nyob rau hauv daim ntawv foos, ua nws tus nqi qis rau kev tswj cov ntshav qab zib hom 2, tshwj xeeb tshaj yog hauv cov peev txheej-txwv chaw.
4. YOOJ YIM NROG RAU LWM YAM
Yuav siv tau nyob rau lwm cov tshuaj kho mob ntawm qhov ncauj lossis insulin, muab txoj hauv kev hloov tau yooj yim thaum muaj kev tiv thaiv kev siv taus thaum muaj kev tsis txaus.
5. Ntev Keeb Kwm Keeb Kwm
Glyburide tau siv txij li xyoo 1960 thiab tau kawm zoo, muaj kev nkag siab zoo ntawm nws cov kev pheej hmoo, cov txiaj ntsig, thiab kev siv cov kev pab cuam.
Tag
Glyburide yog ib tug zoo-tsim cov tshuaj antidiabetic tus neeg sawv cev hauv SulfonyLireTa chav kawm, muaj nuj nqis rau nws cov txiaj ntsig kev txo qis thiab txo qis. Nws plays lub luag haujlwm tseem ceeb hauv kev tswj hwm hom 2 mob ntshav qab zib, tshwj xeeb hauv cov neeg mob glycemic nrog txoj kev ua neej nyob ib leeg. Nws lub peev xwm los txhawb cov kev tso taub insulin ua kom nws ua tau zoo, tshwj xeeb hauv cov theem ua ntej muaj ntshav qab zib thaum porcreatic-tus muaj nuj nqi tseem khaws cia. Thaum nws muaj cov txiaj ntsig tseem ceeb, ua tib zoo soj ntsuam yog qhov tseem ceeb vim yog kev pheej hmoo ntawm hypoglycemia thiab qhov hnyav. Zuag qhia tag nrho, Glyburide tseem yog ib qho cuab yeej tseem ceeb nyob hauv cov khoom muaj ntshav qab zib, tshwj xeeb tshaj yog nyob rau hauv cov chaw uas raug nqi yog qhov tseem ceeb yog qhov tseem ceeb.
Cim npe nrov: Glyburide 丨 CAS 10238-21-8, Tuam Tshoj Glyburide 丨 CAS 10238-21-8 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas
