Hangzhou Leap Chem Co., Ltd. yog ib qho ntawm cov tuam txhab tshaj lij thiab cov chaw muag khoom ntawm tri-galnac(oac)3 tfa丨cas 1159408-65-7 hauv Suav teb. Txais tos rau kev lag luam wholesale kev cai ua cov khoom lag luam ntawm tus nqi sib tw los ntawm peb lub hoobkas. Rau cov khoom pheej yig dua, tiv tauj peb tam sim no.
Specifications
| Qhov tshwm sim | Tawm -dawb lossis grey- cov hmoov dub |
| Tus Kheej (los ntawm 1H NMR) | Ua raws li cov qauv |
| Purity (HPLC) | 95.0% min |
| Qhov siab tshaj plaws ib qho impurity | 1.0% max |
| Residual kuab tshuaj | 6.0% max |
| Cov dej noo | 2.0% max |
Daim ntawv thov
Tri-GalNAc(OAc)3 TFA feem ntau yog siv rau hauv kev tshawb fawb tshuaj thiab kev xa tshuaj, tshwj xeeb tshaj yog nyob rau hauv kev txhim kho daim siab- cov tshuaj kho mob. Nws ua haujlwm raws li GalNAc-raws li ligand uas ua rau muaj kev xaiv khi rau asialoglycoprotein receptor qhia ntawm hepatocytes. Cov tshuaj no tau siv dav hauv kev tsim thiab kev sib txuas ntawm cov hom phiaj conjugates, suav nrog oligonucleotide, siRNA, antisense, thiab me -cov tshuaj molecule conjugates npaj rau kev xa cov kab mob siab. Hauv cov chaw tshawb fawb, nws yog siv los ua ib qho nruab nrab rau kev kawm receptor-mediated endocytosis, optimizing ligand density, thiab ntsuam xyuas cov qauv-kev sib raug zoo hauv daim siab-cov phiaj xwm tshwj xeeb. Nws kuj txhawb kev txhim kho cov txheej txheem sib txuas ua ke rau cov tshuaj precision thiab nucleic acid kho.
Cov txiaj ntsig
Tri-GalNAc(OAc)3 TFA muaj cov txiaj ntsig zoo vim nws muaj zog thiab xaiv kev sib raug zoo rau hepatocyte receptors. Lub triantennary GalNAc qauv txhim kho kev sib txuas ua haujlwm thiab kev siv ntawm tes, ua rau kev txhim kho kev xa khoom ntawm kev kho mob rau lub siab hlwb. Cov acetyl-cov pab pawg tiv thaiv hydroxyl muab tshuaj lom neeg ruaj khov thaum sib xyaw thiab tuav, thaum tso cai rau kev tiv thaiv kev tiv thaiv nyob rau theem tom ntej. Nws cov qauv txhais tau ua kom muaj kev rov ua dua tshiab thiab sib xws hauv cov txheej txheem sib txuas, uas yog qhov tseem ceeb rau kev tsim kho tshuaj. Tsis tas li ntawd, qhov sib xyaw ua ke txhawb kev txo qis kev raug mob thiab tawm ntawm- cov txiaj ntsig los ntawm kev ua kom lub hom phiaj xa khoom, txhim kho kev kho mob thiab kev nyab xeeb profiles hauv kev tsim tshuaj.
Xaus
Tri-GalNAc(OAc)3 TFA yog lub hom phiaj tseem ceeb heev rau ligand rau daim siab- qhia kev xa tshuaj thiab kev tshawb fawb tshuaj. Nws cov ntawv thov hauv GalNAc-kev kho mob sib txuas, ua ke nrog cov txiaj ntsig xws li kev sib raug zoo ntawm cov neeg txais siab, kev tiv thaiv kev tiv thaiv, thiab kev ua tau zoo dua qub, ua rau nws yog ib qho tseem ceeb hauv kev txhim kho tom ntej - tiam daim siab - kev kho mob. Cov tshuaj txuas ntxiv txhawb nqa kev nce qib hauv cov tshuaj precision, nucleic acid kho, thiab cov tshuaj xa mus rau cov thev naus laus zis.
Cim npe nrov: tri-galnac(oac)3 tfa丨cas 1159408-65-7, Tuam Tshoj tri-galnac(oac)3 tfa丨cas 1159408-65-7 manufacturers, lwm tus neeg, Hoobkas
