Cov lus qhia tshwj xeeb ntawm FMOC-L-Glutamic Acid 5- Allyl Ester 丨 CAS {3}}
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Zog: |
Dawb rau off-dawb hmoov |
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Purity (HPLC): |
98. {0}% min |
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Kev Purity Ovority: |
{{0 {}}. 5% Max |
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Cov ntsiab lus dej (KF): |
1. {0 max |
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Kev sib hloov tshwj xeeb: |
{{{{{0}}}}. {}} Degree ± 2.0 degree (c} hauv dmf) |
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Poob rau ziab: |
1. {0 max |
FMOC-L-Glutamic Acid 5- Allyl Ester ntawm L-Glutamic Acid, dav siv hauv Synthesis (SPPS) thiab Combinatorial Chemistry.
Cov ntawv thov ntawm FMOC-L-Glutamic Acid 5- allyl ester 丨 CAS {3}}
1. Peptide synthesis (SPPS)
a. OrthoR Proferion lub tswv yim:
FMOC-L-Glutamic Acid {2}} allyl ester 丨 cas} yog feem ntau siv hauv fmoc \/ tbu-based tau-theem peptide synthesis. Lub molecule muaj ob pawg neeg tiv thaiv tseem ceeb:
FMIC FMOC (N-Terminal): Tshem tawm los ntawm cov hauv paus me (piv txwv li, piperidine).
● Allyl ester (sab saw carboxylic acid): tshem tawm xaiv tau siv pd (}}}}}}}}}}}}) - lwm yam acid-labile pawg.
Qhov no orthogonality pab:
● Xaiv sab-saw tsis txaus ntseeg rau kev ua haujlwm (piv txwv li sab-saw cyclization, sau npe).
Resin kev hloov kho, xws li branching lossis sab-saw mus rau tom qab kev sib tw.
● Khoom siv hluav taws xob ntawm cov txheej txheem sib xyaw, nrog rau cyclic peptides, lactams, thiab censtrained motifs.
b. Yuam sij hauv caj qaum thiab sab-saw cyclization:
Thaum npaj cyclic peptides lossis cov mem dej allyl yog muab tshem tawm kev xaiv kom tso cai rau kev sib raug zoo ntawm cov pab pawg thiab cov amine dawb. Qhov no ua rau:
● Sab-saw mus rau n-terminal cyclization
● Lactam choj tsim
2. Protein engineering thiab cov txheej txheem biology
a. Qhov chaw kawm ntawv tshwj xeeb:
Kev tiv thaiv glutamic acid muaj txiaj ntsig hauv Segenificed paib lossis kev hloov kho cov protein thiab peptides, tshwj xeeb thaum siv cov qauv tshuaj lom neeg.
b. Peptidomimetics thiab Scaffold Tsim:
Nws tau ua haujlwm hauv kev tsim qauv ntawm Peptidomimetic qauv, uas xaiv kev tswj kav ntawm sabins yuav tsum tau ua kom nruj lossis bioctive mojers.
3. Cov Tshuaj Kho Mob Chemistry thiab Tshuaj Xyuas Kev Pom
a. Tshuaj-zoo li peptide derivatives:
FMOC-L-Glutamic Acid 5- Allyl Ester ua haujlwm ua tus thawj coj los tsim kho peptide-based capapeutics, tshwj xeeb:
● Cyclic neeg txwv tsis pub muaj cov enzymes lossis receptors
● Peptides nrog hloov kho solubility lossis ruaj khov
b. Enzyme inhibitor kev loj hlob:
Xaiv sab-saw activation tso cai rau cov pab pawg uas cov ntsiab lus hloov pauv ntawm cov enzymes, tshwj xeeb tshaj yog cov kev sib txuas lus nrog cov roj carboxylic (piv txwv li, kev tiv thaiv, Kinases).
4. Combinatorial thiab tsev qiv ntawv synthesis
Nyob rau hauv high-aws cov synthesis nqis (piv txwv li, ib-khoob-compound lossis solomped combinatorial combinatorial combraries), cov compound ua:
● Kev sib xyaw ua ke tau zoo rau ntau cov tsev qiv ntawv sib txawv
● Kev hloov kho npe nrov tom qab los ntawm sab-saw anemistry
● Sib sib piv nrog Orthoogen tiv thaiv pab pawg tswv yim
Cov txiaj ntsig ntawm fmoc-l-glutamic acid 5- allyl ester 丨 CAS {}}
1. Orthous tiv thaiv pab pawg pab kom meej tswj
Kev sib xyaw ua ke ntawm FMOC thiab AllyL muab lub tswv yim muaj zog los tswj ob txoj saw tseem ceeb thiab sab ntug ywj siab, tsis muaj kev sib tshuam ib sab, tsis muaj kev sib tshuam ib sab, tsis muaj kev sib tshuam ib sab, tsis muaj kev sib tshuam ib sab. Qhov no tso cai rau qib Peptide Adventide thiab xaiv cov ua haujlwm ua haujlwm.
2. Kev txhawb nqa Cyclization thiab ua ke tsim nyog
Los ntawm kev tso cai xaiv deprotection ntawm cov pab pawg -carboxyl, nws txhawb nqa synthesis ntawm conferrained peptides. Cov no muaj txiaj ntsig rau:
● Cov phiaj xwm nce ntxiv
● Kev txhim kho metabolic ruaj khov
● Zoo dua cov pa
3. Siab Compatibility nrog Cov Qauv Txheej Txheem Txheej Txheem
Nws sib xyaw ua ke nrog kev siv hluav taws xob peptide synthesis, siv FMOC Chemistry. Cov pab pawg ALLYL kev xaiv tshem tawm siv pd ({{}}}}}}}) ua kom muaj ntau yam kev tiv thaiv pab pawg.
4. Versatile lub tsev thaiv rau cov molecules complexules
Seb puas tau cyclic peptides, branched peptides, lossis peptidomimetics, fmoc-l-glutamic acid tau ua thiab txhim kho cov qauv tsim thiab synthesis ntawm cov kab ke sib txuas.
Tag
FMOC-L-Glutamic Acid {2}} allyl ester 丨 cas} Yog ib qho zoo hluav taws xob kev tiv thaiv thiab xaiv cov haujlwm. Nws yog qhov tshwj xeeb tshaj yog nyob rau hauv cov ntawv thov uas yuav tsum tau tswj hwm sab saws sab, xws li cyclic peptide synthesis, caj qaum-saw cyclization, thiab bioconjugation. Siv dav hauv cov tshuaj chemistry, cov txheej txheem kev coj ua, thiab cov pa hluav taws xob, qhov ntsuas hluav taws xob tseem ceeb txuas ntxiv ua cov khoom siv tseem ceeb, ruaj khov, thiab cov qauv peptive peptide.
Cim npe nrov: FMOC-L-Glutamic Acid {2}} allyl ester {}}}}}} Cov neeg tsim khoom, cov chaw tsim khoom, Hoobkas
