3,5-diiodo-l-thylineine 丨 CAS 1041-01-6

Lub ntsiab

3,5-diiodo-l-thyodonine 丨 CAS 1041-01-6 yog aLawm tshwm sim endogenous thyroid hormone metaboliteCov. Nws tshwm sim los ntawm deiodiny ntawm triiodothine (T3) thiab tau txais kev txaus siab rau nwsTsis-Genomic Metabolic mob, tshwj xeeb hauv kev tswj hwmLub zog metabolismthiabRog oxidation.

Cov Ntawv Thov

1. Biomedical thiab Endocrine Kev Tshawb Fawb

Thyroid Hormone Kev Kawm Txuj Ci Kev Kawm Txuj Ci:
T2 yog kawm kom nkag siab txogTsis-genomic uaNtawm cov thyroid cov tshuaj hormones, vim nws exerts biological kev ua si ntawm nuclear cov thyroid hormone receptors (TRS).

Mitochondrial Function Kev Ntsuam Xyuas:
Nws txhim kho mitochondrial ua pa thiab oxidative phosphorholation, ua rau nws muaj txiaj ntsig zoo rau kev tshawb nrhiavmitochondrial bioenergegeticsthiab tsis sib xws.

2. Metabolic thiab Kev Tshawb Fawb Kev Lom Zem

Kev pham tiv thaiv (sim):
T2 tau qhia tias muaj peev xwm qhia tauUa kom muaj kev ntsuas qhov chaw ntawm Metabolic (BMR)thiabTxhawb Lipid OxidationYog tsis muaj cov kev mob hnyav uas cuam tshuam nrog T3 lossis T4 txoj kev kho mob.

Daim siab muaj roj teeb:
Hauv tsiaj qauv, T2 schiget coj mus rauTxo hepatic steatosis(Rog mob siab), tawm tswv yim muaj peev xwm hauvTsis muaj dej cawv filty daim siab mob (nfllld)Kev Tshawb Fawb.

Thermogenesis ua kom:
Nws yuav tau txhawbuncoupling protein (UCPs)Hauv av av adipose ntaub so ntswg, txhim kho thermogenic lub zog siv nyiaj.

3. Kev tshawb fawb thoob plaws

Kev Tiv Thaiv Cardiometabololic:
T2 tau raug tshaj tawm los txhim khoLub Luag Haujlwm Cardthiab txocov roj (cholesterol) thiab triglyceride ntau ntauHauv kev tshawb fawb preclinical, qhia nws lub luag haujlwm hauvCov mob metabolic syndromethiabAtherosclerosisKev Tshawb Fawb.

4. Kev kuaj mob thiab tshuaj ntsuam kev siv

Kev siv cov compound hauv cov cia:
T2 yog siv los ua aTxheem lossis sivHauv kev ntsuas cov kev ntsuas rau cov thyroid hormone metabolites nyob rau hauv kev kuaj mob biological (piv txwv li, lc-ms / ms cia).

Cov kev tshawb fawb Biomarker:
Nws tau tshawb xyuas raws li lub peev xwmsam rojRau cov thyroid kev ua si lossis dysretregulation nyob rau hauv qee qhov endocrine tsis kam.

Cov txiaj ntsig

1. Mitochondrial stimulation thiab lub zog siv nyiaj

Sai tau nceCov pa oxygenthiabATP Turnover, tshwj xeeb tshaj yog nyob rau hauv daim siab thiab pob txha leeg.

Txhim khoFatty acid oxidation, ua kom nws zoo nyob rau hauv kev txo lipid nce ntxiv.

2. Tsawg txoj kev pheej hmoo ntawm thyrotoxicity

Piv rau T3 lossis T4, T2 qhiaTsawg heev cuam tshuam rau lub plawv dhia, leeg nqaij catabolism, thiab cov pob txha ceev, uas yog cov kev txhawj xeeb uas ib txwm muaj hauv hyperthyroidism.

3. Lub hom phiaj metabolic mob

Cov Tub Txib ntawm cov kev ntsuas metabolic tsis muaj kev ua haujlwm hormonal.

Muaj peev xwm los khodyslipidemiathiabCov tshuaj insulin Kujnrog tsawg dua kev phiv.

4. Kev tshawb fawb qhov tseeb

Muaj tus qauv muaj nuj nqis rauHormone metabolism, deiodinase kev ua si, thiabTsis-Genomic Ua Haujlwmnyob rau hauv ob leeg thiab tsiaj.

Tag

3,5-diiodo-l-thylineine 丨 CAS 1041-01-6yog ib qho tseem ceebThyroid Hormone Metabolitenrog cov luag haujlwm sib txawv thiab kev xaiv hauv kev tswj hwmLub zog metabolism, cov roj oxidation, thiabmitochondrial kev ua siCov. Nws cov cim tshwj xeeb ua rau nws muaj tus neeg sib tw sib tw rauKev kho mob hauv kev rog, rog ua kab mob siab, thiab cov teeb meem metabolicCov. Thaum tseem nyob rau hauv kev tshawb nrhiav, nws qhov kev ua tau qis thiab hom phiaj ua txuas ntxiv rau kev nyiam kev txaus siab hauv kev tshawb fawb thiab endocrine.