Poov tshuaj trimethylsilanolate 丨 cas 10519-96-7

Poov tshuaj Totassilsilsilsilsilsilsilsilsilsilsilsilsilsilsilsilsilsilsility (Kosime₃) yog qhov muaj zog, non-nucleophilic puag hauv cov organic thiab cov organometallic Chemistry. Nws cov theem siab siab thiab cov qauv sib txawv ntawm cov khoom sib txawv ua rau nws muaj txiaj ntsig rau ntau yam hluavtaws thiab muaj lub hom phiaj muaj:

1. Hauv paus rau hauv cov khoom siv organic

Kosime₃ yog ib lub zog haib, siv nyob rau hauv cov kev cuam tshuam uas cov qauv organic (piv txwv li, lossis organic amines) tsis muaj zog lossis xaiv txaus:

Tsis txaus ntseeg ntawm cov qaug zog acidic protons, xws li uas nyob ib sab rau carbonhls lossis cov nplhaib uas muaj ntxhiab.

Saib xyuas kev tshem tawm, hws, thiab cov kev tiv thaiv rov qab.

Feem ntau siv nyob rau hauv:

Ester faib kev tsim

Silyl enol ether synthesis

Xaiv cov deprotection ntawm acid-labile pawg

2. Cov Neeg Sawv Cev Zoo

Raws li ib qho silan, nws ua raws li ob qho tib si nucleophilic silicon qhov chaw thiab lub hauv paus:

Siv los qhia cov chimethylsillyl (tms) tiv thaiv pab pawg mus rau haus cawv, phenols, thiab carboxylic acids:

Roh + Kosime₃ → Rosime₃ + koh

Cov TMS TMS cov neeg coj ua neeg lossis Esters muaj txiaj ntsig hauv:

Kev tiv thaiv pawg pab pawg hauv ntau kauj ruam organic synthesis

Txhim kho qhov tsis sib xws rau GC Kev Ntsuam Xyuas

Hloov kho solubility thiab reactivity

3. Polymer Chemistry thiab Silicon-Raws Li Cov Ntaub Ntawv

Hauv Silicone Chemistry, Kosime₃ ua haujlwm hauv:

Depolymerization lossis rov sib yuav ntawm polysiloxanes

Pib polymerization ntawm canclic sixananes (xws li D₄ lossis D₅)

Kawg pab pawg hloov kho ntawm cov siloxane polymers

Qhov no ua rau nws muaj txiaj ntsig hauv kev tsim khoom lossis hloov kho:

Silicone Elastomers

Surfactants

Dej-pleev xim pleev xim

Cov ntaub pua xau cov kua los yog cov khoom ua haujlwm

4. Catalyst lossis reagent nyob rau hauv cov kev hloov tsheb hlau-hlau

Kosime₃ feem ntau siv nyob rau hauv airometallic synthesis li:

Lub hauv paus los tsim cov hlau alkyl lossis arylary

Kev hloov kho liigand thaum npaj cov khoom siv hlau lossis tiv thaiv cov hlau

Piv txwv li: nws tuaj yeem tsim nyog rau deprotonate ligands lossis tswj cov chaw muag khoom qis tsawg hauv palladium, npib tsib xee, thiab ruthenium complexes.

5. Desilylation reagent

Txawm li cas los xij, txawm hais tias yog ib qho silylating reagent, Kosime ans kuj tseem tuaj yeem pab ua lwm yam silyl pab pawg, ua rau nws muaj txiaj ntsig hauv kev xaiv tsis txaus ntseeg.

6. Cov ntawv thov hauv cov tshuaj chemistry thiab agnemicals

Hauv kev siv tshuaj, Kosime₃ yog siv:

Txhawm rau tsim TMS-tiv thaiv kev tiv thaiv nruab nrab thaum nquag tshuaj tshuaj paus (API) synthesis.

Hauv kev tshuaj tiv thaiv thiab kev ua kom zoo dua, tshwj xeeb tshaj yog qhov twg cov hauv paus me, cov hauv paus siab yog xav tau.

Nws siv kuj tau sau tseg nyob rau hauv synthesis ntawm kev nplua tshuaj, tsw thiab cov ntxaij teb, thiab agnemical intermediates.

Poov tshuaj trimethylsilanolate muaj ntau yam zoo sib txawv vim nws cov qauv silicon-raws li cov cim thiab cov cim muaj zog:

1. Muaj zog, xaiv lub hauv paus

Muaj zog ntau dua li alkali hydroxides lossis alkoxides.

Tsis yog nucleophilic, lub ntsiab lus nws tsis yooj yim tawm tsam carbonyls lossis rhiab Electrophilic cov chaw-zoo rau kev ua kom pom kev zoo.

2. Yooj Yim thiab Siv Tshuaj Tiv Thaiv

Feem ntau siv hauv cov mob me, mob siab (hauv cov kuab tshuaj zoo li thf lossis toluene).

Ua tau yooj yim los ntawm cov khoom siv pov tseg yooj yim xws li cov tshuaj nyeem potassium lossis cov Silanols.

3. Zoo heev rau kev tiv thaiv chemicals

Ua tau zoo thiab siab-yielding silylation ntawm hydroxyl thiab carboxylic kua qaub.

TMS-tiv thaiv Intermediates yog ruaj khov, volatile, thiab yooj yim tsis tshua muaj, ua rau lawv zoo tagnrho rau:

GC / MS Kev Tshawb Xyuas

Peptide Chemistry

Polysaccharide Hloov Kho

4. Pab tau nyob rau hauv Silicone ua

Ua si lub luag haujlwm tseem ceeb hauv kev hloov kho Siloxanes, tshwj xeeb tshaj yog nyob rau hauv cov khoom rov ua dua tshiab lossis cov roj ntawm cov roj silicone thiab elastomers.

Txhim kho kev tswj hwm cov molecular hnyav thiab cov pab pawg kawg.

5. Tau tshaj tawm cov oconometallic tshuab

Tau tshaj nrog kev nkag mus txawv cov hlau catalysts.

Feem ntau siv los tsim cov hlau-oxygen lossis hlau-silicon bonds, lossis ua kom cov txiv ntoo uas ua kom muaj catalysis.

6. Versatility hauv kev kuaj thiab kev siv

Siv tau ob qho tib si me-teev chav tsev synthesis thiab loj-teev kev tsim khoom, suav nrog:

Qeb thiab khoom siv hluav taws xob

Tej Tshwj Xeeb Txheej

Cov nplaum thiab roj nplua nyeem raws li cov siloxane chemistry