N-Acetyl-D-mannosamine 丨 CAS 3615-17-6

N-Acetyl-D-mannosamine yog dav siv hauv kev tshawb fawb biochemical, kev tsim kho tshuaj, thiab glycobiology vim nws lub luag haujlwm tseem ceeb hauv kev tsim cov sialic acids, tshwj xeeb tshaj yog N-acetylneuraminic acid. Nws yog feem ntau siv hauv kev tshawb fawb ntawm glycosylation txoj hauv kev, cellular metabolism, thiab sialylation txheej txheem, ua rau cov kws tshawb fawb los tshawb xyuas cov kev cai thiab kev ua haujlwm ntawm sialic-acid-muaj glycoconjugates. Hauv kev tshawb fawb tshuaj, nws ua haujlwm ua cov khoom pib lossis nruab nrab rau kev sib txuas ntawm sialic acid derivatives thiab oligosaccharides cuam tshuam rau kev tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tiv thaiv - kev txhim kho tshuaj inflammatory. Nws kuj tseem siv tau rau hauv metabolic glycoengineering, qhov uas nws tuaj yeem nkag mus rau hauv cov hlwb kom hloov kho cell{10}}nto glycan qauv rau kev ntsuas, tsom, lossis kev siv kho mob. Tsis tas li ntawd, N-Acetyl-D-mannosamine yog siv rau hauv kev tshawb fawb noj zaub mov thiab biomedical tshawb nrhiav nws lub luag haujlwm tseem ceeb hauv kev txhawb nqa sialic acid ntau lawm hauv cov menyuam mos, hloov kho lub cev tiv thaiv kab mob, thiab cuam tshuam rau kev loj hlob ntawm paj hlwb. Nws cov khoom siv txuas ntxiv mus rau kev tshuaj ntsuam chemistry thiab biotechnology, qhov uas nws pab tsim cov kev ntsuam xyuas thiab cov cuab yeej rau kev kawm carbohydrate-protein kev sib cuam tshuam, glycan paub, thiab enzymatic transformations.

N-Acetyl-D-mannosamine muaj ntau qhov zoo uas ua rau nws yog ib qho tseem ceeb hauv kev tshawb fawb glycobiology thiab biomedical tshawb fawb. Nws txoj kev koom tes ncaj qha hauv sialic acid biosynthetic txoj kev tso cai rau kev tswj hwm thiab kev hloov pauv ntawm sialylation hauv cov tshuab sim, txhawb cov kev tshawb fawb ntxaws txog glycan zog thiab kev sib txuas lus ntawm tes. Cov tshuaj sib xyaw ua ke muaj txiaj ntsig zoo hauv cov tswv yim metabolic labeling vim tias cov hlwb tau nkag mus rau hauv sialic-acid-txoj kev cuam tshuam, ua kom pom kev pom lossis kev tswj hwm ntawm glycans nrog kev cuam tshuam tsawg kawg rau kev ua haujlwm ib txwm muaj. Raws li ib tug hluavtaws intermediate, nws muab siab purity thiab reproducibility, txhawb txhim khu kev qha zus tau tej cov sialylated molecules rau kev kho mob los yog kev tshawb nrhiav. Nws compatibility nrog enzymatic thiab tshuaj synthesis cov tswv yim txhim kho nws tus nqi hauv kev tsim cov glycoconjugates complex. Kev tshawb fawb qhia tias nws yuav pab txhim kho sialic acid muaj nyob rau hauv physiological cov ntsiab lus uas xav tau siab, muab cov txiaj ntsig zoo hauv kev loj hlob biology thiab kev tshawb fawb neurobiology. Qhov sib xyaw ua ke tsis tshua muaj toxicity thiab kev ruaj ntseg zoo ntxiv txhawb nws txoj kev siv hauv cov kab lis kev cai ntawm tes, kev soj ntsuam biochemical, thiab kev ua qauv ua ntej.