5-Benzylthio-1H-Tetrazy 丨 CAS 21871-47-6

Cov Ntawv Thov

1. Tshuaj Nruab Nrab

5-benzylthio-1h-tetrazole 丨 CAS CAS 21871-47-6 yog siv los ua aQhov tseem ceeb tsev thaivHauv synthesis ntawmArbs (angiotensin II receptor blockers)xws liLosartan, irbesartan, thiab lwm yam Sartan-chav antihyperctives.

Lub nplhaib tetrazole lub nplhaib ua abioisosterentawm cov carboxylic acid pab pawg, txhim kho meabolic stability thiab qhov ncauj bioavailability.

2. Tshuaj Kho Mob Chemistry

Feem ntau siv nyob rau hauvtxhuas ua kom zoothiabTus qauv-kev sib raug zoo (SAR) kev tshawb fawb, tshwj xeeb thaum kev tsim cov tshuaj yuav tsom covrenin-angiotensin system.

Benzylthio hloov kev ntxivlipophilicity, uas tej zaum yuav txhim khumembrane permeabilitythiabphiaj xwm.

3. Tetrazole-raws li cov synthesis

Ua hauj lwmliigand prefursorrau kev sib koom ua ke cov tebchaw hauv cov ntaub ntawv thiab catalysis ua rau nwsnitrogen-nplua nuj nplhaib, uas khi zoo rau cov hlau.

4. Khoom cua organic anpistry

Muaj nuj nqi raws li anucleophile lossis nruab nrabnyob rau hauv heterocyclic synthesis.

Cov pab pawg thioether yog qhov zoo rau kev ua haujlwm ntxiv (oxidation mus rau sulfoxide / sulfone, hloov cov kev cai, thiab lwm yam).

Cov txiaj ntsig

1. Kev hloov pauv hloov rau cov tshuaj tsim

Lub nplhaib tetrazle lub nplhaib mimicsPawg Neeg Kho Mob Carboxylic AcidTab sis muabCov khw muag tshuaj zoo dua, suav nrog:

Ua kom zoolipophilicity

Txhim khoKev nqus qhov ncauj

Kuj musCov teeb meem metabolic

2. Qhov tseem ceeb nruab nrab rau arb cov tshuaj

Ua si lub luag haujlwm tseem ceeb hauv kev tsim cov blockbuster antihpertensive tshuaj, pab tswj cov kab mob plawv.

3. Versatile pawg ua haujlwm

Tus-Sch₂phpab pawg nceHydrophobic sib cuam tshuamNrog lub hom phiaj protein thiab muabHloov kho tesrau kev derivatization ntxiv.

Lub Tetrazle Moamieth impartsacidic thiab kev sib koom tes cov khoom, Siv tau cov tshuaj molecules thiab cov khoom tsim qauv.

4. Scaffold rau Hlau-Organic moj khaum (mofs) thiab catalysis

Vim yog cov qauv nitrogen-nplua nuj, nws tuaj yeem siv rauKoom tes ua cov chaw ua haujlwmHauv synthesis ntawmMofs, catalysts, thiabSensor Cov Ntaub Ntawv.

Lub ntsiab

5-Benzylthio-1H-Tetrazy 丨 CAS 21871-47-6yog ib qho tseem ceebKws Tshuaj Nruab Nrab, tshwj xeeb tshaj yog paub txog nws lub luag haujlwm hauv synthesis ntawmangiotensin II receptor antagonstsxws li Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los ntawm Los Nws cov qauv tshwj xeeb-aLub nplhaib tetrazolehloov chaw nrog apawg benzylthio benzylthio-Offers ua ke ntawmKev ua haujlwm biological, Khoom siv hluav taws xob yooj yim, thiabTshuaj Nyab XeebCov. Dav siv nyob rau hauvTshuaj Kho Mob Tshuaj, Kev Koom Tes Ua Haujlwm, thiabOrganic Synthesis, Cov kab no txhawb nqa ob qho tib si kev lag luam kws muag tshuaj lag luam thiab kev tshawb fawb hauv kev siv tshuaj chemical.